Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor

scientific article published on 04 May 2009

Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20082521
P932PMC publication ID2715023
P698PubMed publication ID19414555
P5875ResearchGate publication ID24400885

P2093author name stringHung-Yun Lin
Chawnshang Chang
Saleh Altuwaijri
Kuo-Pao Lai
Gonghui Li
Peter Keng
Jiann-Jyh Lai
Jong-Wei Hsu
Kuang-Hsiang Chuang
Ming-Chi Wu
Chin-Yi Chu
P2860cites workBiological Actions of AndrogensQ22306226
Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathwayQ24338702
Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cellsQ24339427
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinasesQ24563242
Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferationQ24631073
From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cellsQ24682910
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptorsQ28243582
Specific inhibition of Stat3 signal transduction by PIAS3Q28255665
Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptorQ28589534
Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissuesQ34159764
The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo.Q34323778
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilizationQ52507472
Methods for assessing exocytosis by neutrophil leukocytes.Q53722388
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiationQ57054852
Multiple Signals Mediate Proliferation, Differentiation, and Survival from the Granulocyte Colony-stimulating Factor Receptor in Myeloid 32D CellsQ58483487
The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesisQ62818327
Androgen and erythropoiesis: evidence for an androgen receptor in erythroblasts from human bone marrow culturesQ68095925
Acceleration of granulopoietic recovery by androgenic steroids in mice made neutropenic by cytotoxic drugsQ68787224
The effect of androgens on erythroid and granulocytic marrow recovery in the irradiated ratQ69379348
The Effect of Androgenic Hormones on Bone Marrow of Rats Receiving ChemotherapyQ70724168
Effects of Testosterone and 5 -Androstanes on in Vitro Erythroid Colony Formation in Mouse Bone MarrowQ70774746
The Role of the Androgen Receptor in Erythropoiesis*Q71001840
Protection of human polymorphonuclear leukocyte function from the deleterious effects of isolation, irradiation, and storage by interferon-gamma and granulocyte-colony-stimulating factorQ71704293
Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient miceQ71814481
Reversal of cyclophosphamide induced neutropenia by hypertransfusion and androgen therapyQ72066105
Stimulation of hematopoiesis by androgenic hormonesQ72564217
Treatment of aplastic anaemia with methenolone, stanozolol and nandrolone. A report of 130 casesQ72671337
Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal musclesQ73279585
STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)Q74083332
EFFECT OF OXYMETHOLONE IN REFRACTORY ANEMIAQ76721833
Localization of androgen receptor expression in human bone marrowQ95720991
Impaired antibacterial host defense in mice lacking the N-formylpeptide receptorQ34492932
Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitisQ34654007
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunityQ34762373
Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisisQ35143990
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophilsQ35848810
Fanconi's anemia. Current conceptsQ35858903
Anabolic steroids and bone marrow toxicity during therapy with methotrexateQ36039410
Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cellsQ36664584
Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1.Q36664602
Granulocyte colony-stimulating factor and its receptorQ36697999
The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterizationQ36727002
Proliferation signaling and activation of Shc, p21Ras, and Myc via tyrosine 764 of human granulocyte colony-stimulating factor receptorQ36895621
Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene.Q36900749
Androgen receptor functions in male and female physiologyQ37146863
Subfertility and defective folliculogenesis in female mice lacking androgen receptorQ37388507
A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiationQ37599127
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell lineQ37625031
STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiationQ38303450
Effects of androgenic steroids on erythropoiesisQ39843448
Haemopoietic effects of 7 alpha, 17 beta DimethyltestosteroneQ39883671
The hemopoietic action of androstanesQ40009154
Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern.Q40106805
Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cellsQ40146380
Physiologic mechanisms and the hematopoietic effects of the androstanes and their derivativesQ40157840
Hematologic effects of androgens revisited: an alternative therapy in various hematologic conditionsQ40692528
Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cellsQ41089142
Activation of the human androgen receptor through a protein kinase A signaling pathwayQ41174500
Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stabilityQ41374840
Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factorQ41435735
Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor.Q41461390
Roles of Stat3 and ERK in G-CSF signalingQ42473466
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.Q44021327
Stabilization of androgen receptor protein is induced by agonist, not by antagonistsQ44025388
Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulationQ44071989
Leucopoietic Properties of Four Different Androgenic Hormones in Irradiated RatsQ44089416
Effect of steroids on the cycling of haemopoietic stem cellsQ44823705
Androgen receptor activation by G(s) signaling in prostate cancer cellsQ45226577
High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraceptionQ46499691
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.Q47292718
Chemokine binding and activities mediated by the mouse IL-8 receptorQ48071405
CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection.Q48709220
A Comparison of Two Androgenic Hormones as Leukopoietic Agents in Irradiated RatsQ50237446
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.Q51027830
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1181-1199
P577publication date2009-05-04
P1433published inJournal of Experimental MedicineQ3186912
P1476titleNeutropenia with impaired host defense against microbial infection in mice lacking androgen receptor
P478volume206

Reverse relations

cites work (P2860)
Q90351679A review on the interactions between the tumor microenvironment and androgen receptor signaling in prostate cancer
Q37195600Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem cell antigen-1/ERK pathway.
Q92702546Androgen Receptor and Its Splicing Variant 7 Expression in Peripheral Blood Mononuclear Cells and in Circulating Tumor Cells in Metastatic Castration-Resistant Prostate Cancer
Q90449297Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli
Q27013914Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells
Q36355602Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice
Q36269340Androgen receptors and experimental bone loss - an in vivo and in vitro study.
Q55357541Androgen-Induced Immunosuppression.
Q57800002Androgen-dependent immune modulation in parasitic infection
Q33831959Androgen-induced cell migration: role of androgen receptor/filamin A association
Q90208860Androgens augment pulmonary responses to ozone in mice
Q38542600Cardiovascular risk with androgen deprivation therapy for prostate cancer: potential mechanisms
Q38205189Concise review: androgen receptor differential roles in stem/progenitor cells including prostate, embryonic, stromal, and hematopoietic lineages
Q47559126Deciphering sex differences in the immune system and depression.
Q60955218Do Androgens Modulate the Pathophysiological Pathways of Inflammation? Appraising the Contemporary Evidence
Q46821162Early divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes
Q64113286Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Q47850258FOXO3, estrogen receptor alpha, and androgen receptor impact tumor growth rate and infiltration of dendritic cell subsets differentially between male and female mice
Q38736949Genetic architecture of acne vulgaris.
Q48229904Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer.
Q37074374Hematological changes during androgen deprivation therapy
Q97883534Impact of Androgens on Inflammation-Related Lipid Mediator Biosynthesis in Innate Immune Cells
Q48126981Increased adiposity in DNA binding-dependent androgen receptor knockout male mice associated with decreased voluntary activity and not insulin resistance
Q38635366Increased risk of a herpes zoster attack in patients receiving androgen deprivation therapy for prostate cancer
Q33817447Increased risk of pneumonia in patients receiving gonadotropin-releasing hormone agonists for prostate cancer
Q58767491Inefficient N2-Like Neutrophils Are Promoted by Androgens During Infection
Q97883479Influence of Androgens on Immunity to Self and Foreign: Effects on Immunity and Cancer
Q59334914Interplay among steroids, body condition and immunity in response to long-term captivity in toads
Q34972461Involvement of interleukin-6 and androgen receptor signaling in pancreatic cancer
Q37108694Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells
Q90814492Loss of testosterone impairs anti-tumor neutrophil function
Q37452288Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression
Q37681539Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.
Q55033958No evidence for the immunocompetence handicap hypothesis in male humans.
Q38674708Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles
Q48302490Real-world uptake, safety profile and outcomes of docetaxel in newly diagnosed metastatic prostate cancer.
Q90442504Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review)
Q36945783Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes.
Q39145829Sex Drives Dimorphic Immune Responses to Viral Infections
Q57020537Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection
Q39036728Sex differences in immune responses: Hormonal effects, antagonistic selection, and evolutionary consequences.
Q34581183Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones
Q92733766Sex-specific maternofetal innate immune responses triggered by group B Streptococci
Q41927543Sexual Dimorphism in Innate Immunity.
Q27680640Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase
Q36905079Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR.
Q37207618Targeting stromal androgen receptor suppresses prolactin-driven benign prostatic hyperplasia (BPH).
Q42364449Targeting the androgen receptor in triple-negative breast cancer: current perspectives
Q26765892The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
Q37149457The role of androgen and androgen receptor in skin-related disorders
Q38287957Ubiquitination as an efficient molecular strategy employed in salmonella infection

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