Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

scientific article published on October 1996

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1996PNAS...9310668V
P356DOI10.1073/PNAS.93.20.10668
P932PMC publication ID38212
P698PubMed publication ID8855237
P5875ResearchGate publication ID14350678

P2093author name stringPoolman B
Kok J
Konings WN
Driessen AJ
van Veen HW
Venema K
Bolhuis H
Oussenko I
P2860cites workATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cellsQ24650215
A simple method for displaying the hydropathic character of a proteinQ26778481
Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane.Q27934844
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoproteinQ27939661
ABC Transporters: From Microorganisms to ManQ28181688
Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transportQ28257874
Biochemistry of multidrug resistance mediated by the multidrug transporterQ29616476
Genetic analysis of lipopolysaccharide core biosynthesis by Escherichia coli K-12: insertion mutagenesis of the rfa locusQ30451868
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsQ34059522
A functional superfamily of sodium/solute symportersQ34330234
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.Q34559072
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastineQ34620070
Is the multidrug transporter a flippase?Q35317932
Nucleotide sequence of an Escherichia coli chromosomal hemolysinQ36361105
The Lactococcal lmrP Gene Encodes a Proton Motive Force- dependent Drug TransporterQ36685361
Emr, an Escherichia coli locus for multidrug resistanceQ37215083
Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian systemQ37522093
A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicinQ37598780
Proton motive force-driven and ATP-dependent drug extrusion systems in multidrug-resistant Lactococcus lactis.Q39899044
Construction of plasmid cloning vectors for lactic streptococci which also replicate in Bacillus subtilis and Escherichia coliQ40068341
How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.Q40708077
Prevention of drug access to bacterial targets: permeability barriers and active effluxQ40737334
New mechanisms of drug resistance in parasitic protozoaQ40945183
Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamilyQ41083383
Genetic analysis of the multidrug transporterQ41126344
Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparumQ41945692
A PVC-based electrode sensitive to DDA+ as a device for monitoring the membrane potential in biological systemsQ43539402
PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.Q48085649
The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocatorsQ48142038
Calcium efflux from Escherichia coli. Evidence for two systemsQ67524051
ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P-glycoproteinQ72675932
Functional studies of P-glycoprotein in inside-out plasma membrane vesicles derived from murine erythroleukemia cells overexpressing MDR 3. Properties and kinetics of the interaction of vinblastine with P-glycoprotein and evidence for its active medQ72863901
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectmultiple drug resistanceQ643839
P304page(s)10668-10672
P577publication date1996-10-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMultidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.
P478volume93

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cites work (P2860)
Q28259719A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene
Q33481004A multidrug ABC transporter with a taste for salt
Q44185096A new experimental approach to detect long-range conformational changes transmitted between the membrane and cytosolic domains of LmrA, a bacterial multidrug transporter
Q24539689A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion
Q52169307A role for ectophosphatase in xenobiotic resistance.
Q39567087A silent ABC transporter isolated from Streptomyces rochei F20 induces multidrug resistance.
Q42666847A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA.
Q36352495ABC transporter architecture and regulatory roles of accessory domains
Q33944775ABC transporters in lipid transport
Q44065009ATPase activity of the MsbA lipid flippase of Escherichia coli
Q35138154Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae.
Q44699420An ABC transporter with a secondary-active multidrug translocator domain
Q34109292An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin
Q32069151An export-specific reporter designed for gram-positive bacteria: application to Lactococcus lactis
Q30724303Analysis of a complete library of putative drug transporter genes in Escherichia coli
Q44045404Analysis of the inhibition potential of zosuquidar derivatives on selected bacterial and fungal ABC transporters.
Q55121196Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective.
Q39476891Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes
Q34549813Antimicrobial Peptide Resistance Mechanisms of Gram-Positive Bacteria
Q36230684Antitumor efficacy induced by a B16F10 tumor cell vaccine treated with mitoxantrone alone or in combination with reserpine and verapamil in mice
Q39784418Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae
Q36016933Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin
Q30327976Attenuated total reflection IR spectroscopy as a tool to investigate the structure, orientation and tertiary structure changes in peptides and membrane proteins.
Q53962628Auxin transport: ABC proteins join the club.
Q30050610Beer spoilage bacteria and hop resistance
Q28547182Binding of the Lactococcal Drug Dependent Transcriptional Regulator LmrR to Its Ligands and Responsive Promoter Regions
Q44018708Biochemical characterization of horA-independent hop resistance mechanism in Lactobacillus brevis
Q54107193Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations.
Q41565399CD2068 potentially mediates multidrug efflux in Clostridium difficile
Q42619024Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.
Q39500711Cholate resistance in Lactococcus lactis is mediated by an ATP-dependent multispecific organic anion transporter.
Q42779935Cholate-stimulated biofilm formation by Lactococcus lactis cells.
Q34647294Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria
Q42387142Comparative transcriptional analysis of Bacillus subtilis cells overproducing either secreted proteins, lipoproteins or membrane proteins
Q36704511Computer simulations of ABC transporter components
Q35882173Critical Dipole Length for the Wetting Transition Due to Collective Water-dipoles Interactions
Q36931422Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria
Q33223264Drug-lipid A interactions on the Escherichia coli ABC transporter MsbA.
Q36079458Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations
Q39639033Effects of pressure-induced membrane phase transitions on inactivation of HorA, an ATP-dependent multidrug resistance transporter, in Lactobacillus plantarum
Q35033131Effects of the L511P and D512G mutations on the Escherichia coli ABC transporter MsbA
Q35626332Efflux-mediated drug resistance in bacteria
Q37712986Energy metabolism and drug efflux in Mycobacterium tuberculosis
Q60961106Engineered Strains for Optimal Identification and Expression of Cryptic Biosynthetic Gene Clusters
Q31685505Enhanced multispecificity of arabidopsis vacuolar multidrug resistance-associated protein-type ATP-binding cassette transporter, AtMRP2.
Q37340760Enhanced surface hydrophobicity by coupling of surface polarity and topography
Q39653033Evidence of active efflux in resistance to ciprofloxacin and to ethidium bromide by Mycoplasma hominis
Q35598367Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA
Q35068373Genome comparison of two Magnaporthe oryzae field isolates reveals genome variations and potential virulence effectors
Q39504789Hop resistance in the beer spoilage bacterium Lactobacillus brevis is mediated by the ATP-binding cassette multidrug transporter HorA
Q31109837How to distinguish between the vacuum cleaner and flippase mechanisms of the lmrA multi-drug transporter in Lactococcus lactis
Q35879213Identification and characterization of genes encoding a putative ABC-type transporter essential for utilization of gamma-hexachlorocyclohexane in Sphingobium japonicum UT26.
Q46249281Identification of Nostoc punctiforme akinete-expressed genes using differential display
Q27937633Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugs
Q35011218Increased activity of Pgp multidrug transporter in patients with Helicobacter pylori infection
Q40732372Increased expression of two multidrug transporter-like genes is associated with ethidium bromide and ciprofloxacin resistance in Mycoplasma hominis
Q84212544Influence of MDR1 polymorphism on H. pylori-related chronic gastritis
Q53853232Inhibition of bacterial efflux pumps: a new strategy to combat increasing antimicrobial agent resistance.
Q39470683Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine.
Q42101354Interactions between P-glycoprotein substrates and other cationic drugs at the hepatic excretory level
Q37740126Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer.
Q38796195Invited review: Architectures and mechanisms of ATP binding cassette proteins
Q33995963Isolation of a hop-sensitive variant of Lactobacillus lindneri and identification of genetic markers for beer spoilage ability of lactic acid bacteria
Q38311050LmrCD is a major multidrug resistance transporter in Lactococcus lactis.
Q33938767Mdt(A), a new efflux protein conferring multiple antibiotic resistance in Lactococcus lactis and Escherichia coli
Q44495023Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli
Q33401731Molecular models of human P-glycoprotein in two different catalytic states
Q28139376Molecular properties of bacterial multidrug transporters
Q52566011MsbA is not required for phospholipid transport in Neisseria meningitidis.
Q57177008Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters
Q37644554Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues.
Q34756470Multidrug resistance: can different keys open the same lock?
Q34290848Multidrug transport by ATP binding cassette transporters: a proposed two-cylinder engine mechanism
Q34807267Multidrug transporters and antibiotic resistance in Lactococcus lactis
Q41115237Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins
Q33538677Multiple antibiotic resistance and efflux
Q33240063Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization
Q37488240NMR and EPR studies of membrane transporters
Q36300806New horizon of MDR1 (P-glycoprotein) study
Q24519031NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli
Q39504988Novel macrolide-specific ABC-type efflux transporter in Escherichia coli
Q38353687Novel mechanism of bacteriocin secretion and immunity carried out by lactococcal multidrug resistance proteins.
Q28478129Optimized purification of a heterodimeric ABC transporter in a highly stable form amenable to 2-D crystallization
Q44659227Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis
Q36895030Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
Q36544614Preface: the concept and consequences of multidrug resistance
Q33455994Probing the conformation of the resting state of a bacterial multidrug ABC transporter, BmrA, by a site-directed spin labeling approach
Q41648380Protein folding coupled to disulphide bond formation
Q30409962Proteins that bind and move lipids: MsbA and NPC1.
Q30648447Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes
Q44075217S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1).
Q33897307Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis.
Q33306298SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescens
Q26741272Stress Physiology of Lactic Acid Bacteria
Q30377396Structural evolution of the ABC transporter subfamily B.
Q35294152Structure and function of efflux pumps that confer resistance to drugs
Q24643436Structure, function, and evolution of bacterial ATP-binding cassette systems
Q33784403Structure-function analysis of multidrug transporters in Lactococcus lactis.
Q37048357Substrate binding stabilizes a pre-translocation intermediate in the ATP-binding cassette transport protein MsbA
Q34010123Symmetry and structure in P-glycoprotein and ABC transporters what goes around comes around
Q42421199The ABC transporter AnrAB contributes to the innate resistance of Listeria monocytogenes to nisin, bacitracin, and various beta-lactam antibiotics.
Q33398632The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites
Q35956193The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance
Q38287387The ABC-type multidrug resistance transporter LmrCD is responsible for an extrusion-based mechanism of bile acid resistance in Lactococcus lactis.
Q33187645The ATP binding cassette multidrug transporter LmrA and lipid transporter MsbA have overlapping substrate specificities
Q33981323The AbcA transporter of Staphylococcus aureus affects cell autolysis
Q33556191The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificity
Q33742450The Escherichia coli cmlA gene encodes the multidrug efflux pump Cmr/MdfA and is responsible for isopropyl-beta-D-thiogalactopyranoside exclusion and spectinomycin sensitivity
Q28545890The Nucleotide-Free State of the Multidrug Resistance ABC Transporter LmrA: Sulfhydryl Cross-Linking Supports a Constant Contact, Head-to-Tail Configuration of the Nucleotide-Binding Domains
Q55070232The Transcriptional Regulator TFB-RF1 Activates Transcription of a Putative ABC Transporter in Pyrococcus furiosus.
Q28776849The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism
Q37975919The role of ATP-binding cassette transporters in bacterial pathogenicity
Q34137973The structure and function of drug pumps
Q35044558The structure and function of drug pumps: an update
Q34474134The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux
Q35759598The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus
Q44106140The transmembrane domains of the ABC multidrug transporter LmrA form a cytoplasmic exposed, aqueous chamber within the membrane
Q28834633Xenobiotic efflux in bacteria and fungi: a genomics update
Q44932592ydaG and ydbA of Lactococcus lactis encode a heterodimeric ATP-binding cassette-type multidrug transporter.

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