Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography.

scientific article published on 22 July 2009

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1004031754
P356DOI10.1186/1475-2840-8-39
P932PMC publication ID2722582
P698PubMed publication ID19624828
P5875ResearchGate publication ID26688288

P50authorJolanda van der VeldenQ28595192
Margriet OuwensQ42710179
Adriaan A LammertsmaQ52983347
Christa BoerQ56555985
Charissa E van den BromQ64513635
Michaela DiamantQ108578052
P2093author name stringRonald Vlasblom
Marc C Huisman
Mark Lubberink
D Margriet Ouwens
Suzanne Duijst
Carla F M Molthoff
Nicky M Boontje
P2860cites workEnhanced Sarcolemmal FAT/CD36 Content and Triacylglycerol Storage in Cardiac Myocytes From Obese Zucker RatsQ27832088
Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterificationQ27887261
Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human heartsQ28215203
Translocation of the glucose transporter GLUT4 in cardiac myocytes of the ratQ28581995
Regulation of the activity of the pyruvate dehydrogenase complexQ34747160
Linking gene expression to function: metabolic flexibility in the normal and diseased heartQ35807737
Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implicationsQ35856218
Fatty acid metabolism is enhanced in type 2 diabetic heartsQ36132785
Role of changes in cardiac metabolism in development of diabetic cardiomyopathyQ36496550
Lipotoxic heart disease in obese rats: implications for human obesityQ37117677
Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.Q38321475
Role of PP2C in cardiac lipid accumulation in obese rodents and its prevention by troglitazoneQ38336732
Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigationQ40123899
Regulation of energy substrate metabolism in the diabetic heartQ41526636
Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in ratsQ42477638
Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imagingQ43264985
Myocardial fatty acid oxidation in patients with impaired glucose toleranceQ43554879
Myocardial glucose utilization and optimization of (18)F-FDG PET imaging in patients with non-insulin-dependent diabetes mellitus, coronary artery disease, and left ventricular dysfunctionQ43830048
Cardiac carbohydrate metabolism in Zucker diabetic fatty ratsQ44026484
Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart.Q44081028
Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistanceQ44155540
Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db miceQ44286385
The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.Q44576089
The rapid onset of hyperglycaemia in ZDF rats was associated with a widespread alteration of metabolic proteins implicated in glucose metabolism in the heart.Q44868984
Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.Q45032380
Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty ratsQ45199020
Pioglitazone reverses down-regulation of cardiac PPARgamma expression in Zucker diabetic fatty ratsQ45287356
Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitusQ46059605
Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF ratsQ46410862
Impact of image-space resolution modeling for studies with the high-resolution research tomographQ46568081
Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male miceQ46833712
Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scannerQ48272311
Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure.Q51486077
Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study.Q53543872
Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomographyQ57623385
Calpain-I induced alterations in the cytoskeletal structure and impaired mechanical properties of single myocytes of rat heartQ58087915
Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker ratsQ73015193
Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker ratsQ74371834
Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosisQ79917829
P4510describes a project that usespositron emission tomographyQ208376
P407language of work or nameEnglishQ1860
P921main subjectcardiomyopathyQ847583
diabetic cardiomyopathyQ5270132
P304page(s)39
P577publication date2009-07-22
P1433published inCardiovascular DiabetologyQ2468083
P1476titleAltered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography
P478volume8

Reverse relations

cites work (P2860)
Q46426230A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats
Q48251771Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice
Q36673848Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats.
Q93090024An attempt to reverse cardiac lipotoxicity by aerobic interval training in a high-fat diet- and streptozotocin-induced type 2 diabetes rat model
Q96354091Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study
Q35637980Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses
Q36825744Cardiovascular changes in animal models of metabolic syndrome
Q34999815Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats
Q51366678Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart.
Q36689230Diabetes, perioperative ischaemia and volatile anaesthetics: consequences of derangements in myocardial substrate metabolism.
Q42737141Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
Q30362092Diagnostic approaches for diabetic cardiomyopathy.
Q90103714Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction
Q42145941Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet.
Q37663364Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat.
Q58853825Effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats
Q34198857Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat.
Q37123144Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract
Q48061653High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte.
Q30463370High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study
Q39763308Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Q36364635Hyperglycemia-induced stimulation of glucose transport in skeletal muscle measured by PET-[18F]6FDG and [18F]2FDG.
Q38753602Imaging of myocardial fatty acid oxidation
Q46472199Impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede development of diabetic cardiomyopathy are prevented by resveratrol in ZDF rats
Q47174891Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance
Q35839677Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase
Q37575998Is diabetic cardiomyopathy a specific entity?
Q59794701Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated F-FDG PET
Q50098424Long Term Osmotic Mini Pump Treatment with Alpha-MSH Improves Myocardial Function in Zucker Diabetic Fatty Rats.
Q38084193Mechanisms of subcellular remodeling in heart failure due to diabetes
Q64997759Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.
Q36908289Myocardial AKT: the omnipresent nexus
Q30392800Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats.
Q44804065Myocardial insulin resistance, metabolic stress and autophagy in diabetes.
Q36051462Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice.
Q38156683Recent advances in metabolic imaging
Q37700017Reducing Caloric Intake Prevents Ischemic Injury and Myocardial Dysfunction and Affects Anesthetic Cardioprotection in Type 2 Diabetic Rats.
Q56982060Restoration of myocardial glucose uptake with facilitated GLUT-4 translocation contributes to alleviation of diabetic cardiomyopathy in rats after duodenal-jejunal bypass
Q34479248Rodent models for metabolic syndrome research
Q37294857Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function
Q39398383Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus
Q48043450Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking
Q35100504Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes
Q35206048Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia.
Q58101156The association between diabetes mellitus and reduction in myocardial glucose uptake: a population-based F-FDG PET/CT study
Q34321864The beneficial effects of exercise in rodents are preserved after detraining: a phenomenon unrelated to GLUT4 expression.
Q47161900Whitening and Impaired Glucose Utilization of Brown Adipose Tissue in a Rat Model of Type 2 Diabetes Mellitus

Search more.