Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection

scientific article published on January 2008

Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0079-6123(08)01131-X
P698PubMed publication ID18929127

P50authorCarlo NucciQ67168288
P2093author name stringGiacinto Bagetta
Luigi Antonio Morrone
Mauro Maccarrone
Monica Bari
Arnoldo Spanò
MariaTiziana Corasaniti
P2860cites workIdentification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brainQ22001491
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainQ24299523
Brain monoglyceride lipase participating in endocannabinoid inactivationQ24533828
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M currentQ24653442
Molecular characterization of a phospholipase D generating anandamide and its congenersQ28186509
CB1 cannabinoid receptors and on-demand defense against excitotoxicityQ28207143
Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neuronsQ28245016
In silico patent searching reveals a new cannabinoid receptorQ28284495
The molecular logic of endocannabinoid signallingQ29615356
International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsQ29616832
Formation and inactivation of endogenous cannabinoid anandamide in central neuronsQ29620558
Effect of WIN 55212-2, a cannabinoid receptor agonist, on aqueous humor dynamics in monkeysQ30881082
Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma TrialQ31113402
Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measuresQ33205224
Endothelin B receptor in human glaucoma and experimentally induced optic nerve damage.Q33242789
Neuroprotection in relation to retinal ischemia and relevance to glaucomaQ33693575
The toxic effect of sodium L-glutamate on the inner layers of the retina.Q33969485
Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure.Q34072766
An endogenous cannabinoid (2-AG) is neuroprotective after brain injuryQ34093755
N-Acylethanolamines and precursor phospholipids - relation to cell injuryQ34098995
The therapeutic potential of cannabisQ34212503
Cannabinoid physiology and pharmacology: 30 years of progress.Q34355485
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidaseQ34385277
Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.Q34397288
The synthetic cannabinoid WIN55212-2 decreases the intraocular pressure in human glaucoma resistant to conventional therapiesQ34513181
A second fatty acid amide hydrolase with variable distribution among placental mammalsQ34570802
Cannabinoid receptors and their ligandsQ34673022
Functions of cannabinoid receptors in the hippocampusQ34750566
Cannabinoids and neuroinflammationQ35046205
Possible role for memantine in protecting retinal ganglion cells from glaucomatous damageQ35174032
Increased plasma endothelin-1 levels in patients with progressive open angle glaucomaQ35592811
Retinal ischemia: mechanisms of damage and potential therapeutic strategiesQ35650660
Cannabinoids and glaucomaQ35748271
Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitriteQ35843412
Cannabinoids and neuroprotection in CNS inflammatory diseaseQ36127875
Structure and function of fatty acid amide hydrolaseQ36161171
Activation of CB1 cannabinoid receptors inhibits neurotransmitter release from identified synaptic sites in rat hippocampal culturesQ73457865
Metabolism of anandamide, an endogenous cannabinoid receptor ligand, in porcine ocular tissuesQ73562118
Effects of topical alpha-substituted anandamides on intraocular pressure in normotensive rabbitsQ74131027
Mechanism of the pathogenesis of glutamate neurotoxicity in retinal ischemiaQ77510870
Marijuana smoking vs cannabinoids for glaucoma therapyQ77583123
Effect of the CB1 receptor antagonist, SR141716A, on cannabinoid-induced ocular hypotension in normotensive rabbitsQ77674840
Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoidQ79370475
Primary open-angle glaucomaQ80122027
Cannabinoid agonist WIN 55212-2 speeds up the cone response to light offset in goldfish retinaQ83200961
Noladin ether acts on trabecular meshwork cannabinoid (CB1) receptors to enhance aqueous humor outflow facilityQ83201977
Histologic changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamateQ93647550
Cannabinoid receptors and their role in neuroprotectionQ36211444
Endocannabinoid metabolic pathways and enzymesQ36352186
The endocannabinoid pathway in Huntington's disease: a comparison with other neurodegenerative diseasesQ36727554
Biochemistry and pharmacology of endovanilloidsQ36756199
The (endo)cannabinoid system in multiple sclerosis and amyotrophic lateral sclerosisQ36902277
Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of actionQ37086961
Activity-based protein profiling: from enzyme chemistry to proteomic chemistryQ37119021
Dronabinol and retinal hemodynamics in humansQ39779600
Agonist-dependent cannabinoid receptor signalling in human trabecular meshwork cellsQ40070777
Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells.Q40224855
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolismQ40817229
Molecular basis of glutamate toxicity in retinal ganglion cells.Q40873212
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatumQ42523780
R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cellsQ42674843
Cannabinoid agonists induce relaxation in the bovine ophthalmic artery: evidences for CB1 receptors, nitric oxide and potassium channelsQ43038421
Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits.Q43672168
Interaction between delta-9-tetrahydrocannabinol and indomethacinQ43682118
Cannabinoids and brain injury: therapeutic implicationsQ43869210
Vitreous amino acid concentrations in patients with glaucoma undergoing vitrectomy.Q44313042
Presynaptic Facilitation of Glutamatergic Synapses to Dopaminergic Neurons of the Rat Substantia Nigra by Endogenous Stimulation of Vanilloid ReceptorsQ44418969
Cannabinoids inhibit neurodegeneration in models of multiple sclerosisQ44522438
Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effectsQ44915044
Vanilloid receptor like 1 (VRL1) immunoreactivity in mammalian retina: colocalization with somatostatin and purinergic P2X1 receptorsQ44918609
Vitreous and retinal amino acid concentrations in experimental central retinal artery occlusion in the primateQ44927514
Cannabinoid agonists induce contractile responses through Gi/o-dependent activation of phospholipase C in the bovine ciliary muscleQ44934399
Molecular basis for species-specific sensitivity to "hot" chili peppersQ45712451
Finding of endocannabinoids in human eye tissues: implications for glaucomaQ46432377
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's diseaseQ46443478
Reciprocal inhibition of voltage-gated potassium currents (I K(V)) by activation of cannabinoid CB1 and dopamine D1 receptors in ON bipolar cells of goldfish retinaQ46447396
Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat.Q46673234
Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide.Q46936833
Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17beta-estradiolQ48089296
Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in cultureQ48309181
Delta9-tetrahydrocannabinol protects hippocampal neurons from excitotoxicityQ48350622
The cannabinoid agonist Win55,212-2 inhibits calcium channels by receptor-mediated and direct pathways in cultured rat hippocampal neuronsQ48482096
Glutamate release in experimental ischaemia of the retina: an approach using microdialysisQ51688785
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.Q53872479
Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study.Q55042467
Biosynthesis and Inactivation of N-Arachidonoylethanolamine (Anandamide) and N-Docosahexaenoylethanolamine in Bovine RetinaQ60690628
Neuroprotective and Intraocular Pressure-Lowering Effects of (–)Δ 9 -Tetrahydrocannabinol in a Rat Model of GlaucomaQ61053086
Involvement of the Endocannabinoid System in Retinal Damage after High Intraocular Pressure–Induced Ischemia in RatsQ61896991
Retinal Damage Caused by High Intraocular Pressure–Induced Transient Ischemia is Prevented by Coenzyme Q10 in RatQ61897001
Marihuana Smoking and Intraocular PressureQ64962468
Multiple-drop study of topically applied 1% delta 9-tetrahydrocannabinol in human eyesQ67283147
Elevated glutamate levels in the vitreous body of humans and monkeys with glaucomaQ70999763
Effects of topical anandamides on intraocular pressure in normotensive rabbitsQ71094610
The release of amino acids from ischemic retinaQ73399303
P921main subjectcannabinoidsQ422936
P304page(s)451-464
P577publication date2008-01-01
P1433published inProgress in Brain ResearchQ15800382
P1476titlePotential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection
P478volume173