Purified brominated indole derivatives from Dicathais orbita induce apoptosis and cell cycle arrest in colorectal cancer cell lines

scientific article published on 11 October 2013

Purified brominated indole derivatives from Dicathais orbita induce apoptosis and cell cycle arrest in colorectal cancer cell lines is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/MD11103802
P8608Fatcat IDrelease_yr6sp5kxivewpe2evqmbzhfj7i
P932PMC publication ID3826136
P698PubMed publication ID24152558
P5875ResearchGate publication ID258038281

P50authorKirsten BenkendorffQ47159752
Martin R JohnstonQ56949145
Catherine Anne AbbottQ39188539
P2093author name stringBabak Esmaeelian
P2860cites workGlobal cancer statisticsQ22241238
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Prevention of chemotherapy-induced alopecia in rats by CDK inhibitorsQ27629159
GSK-3-selective inhibitors derived from Tyrian purple indirubinsQ27642879
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Q27860674
Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urineQ28203680
Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cellsQ73574350
A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cellsQ80286682
Marine natural productsQ85775737
Sex-specific Tyrian purple genesis: precursor and pigment distribution in the reproductive system of the marine mollusc, Dicathais orbita.Q46853794
Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell deathQ46905283
An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins.Q46988028
Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferationQ47224542
Tyrian Purple: 6,6’-Dibromoindigo and Related CompoundsQ56138636
The endogenous oxindoles 5-hydroxyoxindole and isatin are antiproliferative and proapoptoticQ73006132
Apoptosis in the pathogenesis and treatment of diseaseQ28235731
Apoptosis: a review of programmed cell deathQ28305845
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cellsQ28346772
Natural products as sources of new drugs over the last 25 yearsQ29615119
Innovative agents in cancer prevention.Q30349981
Strategies for discovering drugs from previously unexplored natural productsQ30880493
Natural products as a screening resourceQ33299805
Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscsQ33526826
Antiproliferative effect of alcoholic extracts of some Gabonese medicinal plants on human colonic cancer cellsQ33630539
Caspase structure, proteolytic substrates, and function during apoptotic cell deathQ33782479
Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assaysQ34314238
Direct activation of the apoptosis machinery as a mechanism to target cancer cellsQ35145998
Marine compounds selectively induce apoptosis in female reproductive cancer cells but not in primary-derived human reproductive granulosa cellsQ35759919
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicineQ35876121
Marine natural products as anticancer drugsQ36043234
Overview of cell death signaling pathwaysQ36051647
Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and study of their effect on the cell cycleQ36233471
A death-promoting role for extracellular signal-regulated kinaseQ36519679
Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscsQ36838178
Natural product research in the Australian marine invertebrate Dicathais orbitaQ36994269
Natural products and colon cancer: current status and future prospectsQ37136990
Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.Q37481467
Importance of influx and efflux systems and xenobiotic metabolizing enzymes in intratumoral disposition of anticancer agentsQ37580931
A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells.Q40093765
In vitro cytotoxicity evaluation of some substituted isatin derivatives.Q40211510
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.Q40265640
Modification of MTT assay conditions to examine the cytotoxic effects of amitraz on the human lymphoblastoid cell line, WIL2NS.Q40381015
A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growthQ40435914
A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cellsQ40785882
Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrestQ40794493
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinasesQ40918567
Bioactivity of the Murex Homeopathic Remedy and of Extracts from an Australian Muricid Mollusc against Human Cancer CellsQ41951957
Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventativeQ43164583
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?Q43507724
Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatmentQ43964624
To arrest or not to G(2)-M Cell-cycle arrest : commentary re: A. K. Tyagi et al., Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G(2)-M arrest, and apoptosis. Clin. cancer res., 8: 3512-3Q44214945
Transient induction of cytochromes P450 1A1 and 1B1 in MCF-7 human breast cancer cells by indirubinQ44668644
Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.Q44836647
From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitorsQ45293374
Disorders of folliculogenesis are associated with abnormal expression of peripheral benzodiazepine receptors in granulosa cellsQ46234766
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P921main subjectcolorectal cancerQ188874
Dicathais orbitaQ737213
apoptotic processQ14599311
colorectal carcinomaQ25493920
P304page(s)3802-3822
P577publication date2013-10-11
P1433published inMarine DrugsQ2122804
P1476titlePurified brominated indole derivatives from Dicathais orbita induce apoptosis and cell cycle arrest in colorectal cancer cell lines
P478volume11

Reverse relations

cites work (P2860)
Q375661566-bromoisatin found in muricid mollusc extracts inhibits colon cancer cell proliferation and induces apoptosis, preventing early stage tumor formation in a colorectal cancer rodent model.
Q52881957Allyl-isatin suppresses cell viability, induces cell cycle arrest, and promotes cell apoptosis in hepatocellular carcinoma HepG2 cells.
Q33744128Anti-Inflammatory Activity and Structure-Activity Relationships of Brominated Indoles from a Marine Mollusc.
Q37566258Apoptogenic metabolites in fractions of the Benthic diatom Cocconeis scutellum parva.
Q26795884Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds?
Q28088279Biological Activity of Recently Discovered Halogenated Marine Natural Products
Q47143811Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury
Q64963419Bromoperoxidase Producing Bacillus spp. Isolated from the Hypobranchial Glands of a Muricid Mollusc Are Capable of Tyrian Purple Precursor Biogenesis.
Q35816225Characterization of Bacterial Communities Associated with the Tyrian Purple Producing Gland in a Marine Gastropod.
Q35649627Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats.
Q51084134Extraction and Quantification of Bioactive Tyrian Purple Precursors: A Comparative and Validation Study from the Hypobranchial Gland of a Muricid Dicathais orbita.
Q64236328Induction of Apoptosis by Extract of Persian Gulf Marine Mollusk, through the ROS-Mediated Mitochondrial Targeting on Human Epithelial Ovarian Cancer Cells
Q92882970Mapping insoluble indole metabolites in the gastrointestinal environment of a murine colorectal cancer model using desorption/ionisation on porous silicon imaging
Q43239058Marine Compounds and Cancer: Where Do We Stand?
Q33834080Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.
Q38851937Simultaneous Assessment of the Efficacy and Toxicity of Marine Mollusc-Derived Brominated Indoles in an In Vivo Model for Early Stage Colon Cancer.
Q35228238Solvent separating secondary metabolites directly from biosynthetic tissue for surface-assisted laser desorption ionisation mass spectrometry
Q36083549Transcriptome of the Australian Mollusc Dicathais orbita Provides Insights into the Biosynthesis of Indoles and Choline Esters.
Q90706223Upregulation of DLC-1 inhibits pancreatic cancer progression: Studies with clinical samples and a pancreatic cancer model

Search more.