A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder

scientific article published on December 2008

A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S11920-008-0081-7
P932PMC publication ID2727597
P698PubMed publication ID18980735
P5875ResearchGate publication ID23448108

P2093author name stringCarlos A Zarate
Nancy DiazGranados
P2860cites workThe prevalence and significance of substance use disorders in bipolar type I and II disorderQ21203517
Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot studyQ28248076
Essential role for the PKC target MARCKS in maintaining dendritic spine morphologyQ28568656
A rating scale for mania: reliability, validity and sensitivityQ29619299
Validity of the distinction between primary and secondary substance use disorder in patients with bipolar disorder: data from the first 1000 STEP-BD participantsQ31036087
Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implicationsQ33540359
Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illnessQ33782621
Molecular and cellular mechanisms underlying mood stabilization in bipolar disorder: implications for the development of improved therapeuticsQ34622350
A systematic review of placebo response in studies of bipolar maniaQ34686878
Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifenQ34757926
Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvementQ36293331
Spines and neurite branches function as geometric attractors that enhance protein kinase C actionQ36321000
Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorderQ36400018
Adjunctive treatment of acute mania: a clinical overviewQ36905879
Weight gain and metabolic issues of medicines used for bipolar disorderQ37067704
Molecular mechanisms of antiestrogen action in breast cancerQ40644017
Protein kinase C and dopamine transport--1. Effects of amphetamine in vivoQ44442745
A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar maniaQ44565868
Protein kinase C and dopamine transport--2. Effects of amphetamine in vitroQ44800543
The long-term natural history of the weekly symptomatic status of bipolar I disorderQ46317822
Stabilization of hypomania following initiation of tamoxifenQ46616392
Clinical trials in bipolar mania: implications in study design and drug developmentQ46721063
A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorderQ46852634
Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder.Q48100054
Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA.Q48563872
Enhanced protein kinase C activity and translocation in bipolar affective disorder brainsQ48907362
Altered platelet protein kinase C activity in bipolar affective disorder, manic episodeQ70765278
Phosphorylation of neuromodulin in rat striatum after acute and repeated, intermittent amphetamineQ72258400
A preliminary investigation of a protein kinase C inhibitor in the treatment of acute maniaQ73347340
Cycling into depression from a first episode of mania: a case-comparison studyQ74453207
Models of mania and antimanic drug actions: progressing the endophenotype approachQ81534236
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbipolar disorderQ131755
P304page(s)510-519
P577publication date2008-12-01
P1433published inCurrent Psychiatry ReportsQ25245507
P1476titleA review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder
P478volume10

Reverse relations

cites work (P2860)
Q38165755Contributions of animal models to the study of mood disorders.
Q43923791Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania
Q53495664Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.
Q48056810Inositol depletion, GSK3 inhibition and bipolar disorder
Q48579986Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania
Q47109377Lithium and Tamoxifen Modulate Behavior and Protein Kinase C Activity in the Animal Model of Mania Induced by Ouabain
Q48331624Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania
Q34268501Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: developing treatments using an integrated translational approach
Q37709574New approaches to the pharmacological management of major depressive disorder
Q37923845New drugs for bipolar disorder
Q34026112Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.
Q38846159Polyphenol compounds and PKC signaling
Q30462823Predictive animal models of mania: hits, misses and future directions
Q37141320Protein kinase C, an elusive therapeutic target?
Q35785604Requirement of phospholipase C and protein kinase C in cholecystokinin-mediated facilitation of NMDA channel function and anxiety-like behavior.
Q26853509Review of pharmacological treatment in mood disorders and future directions for drug development.
Q38179926Tamoxifen use for the management of mania: a review of current preclinical evidence
Q47975522The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine

Search more.