PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.

scientific article published on October 2008

PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.200838137
P932PMC publication ID2727707
P698PubMed publication ID18825752
P5875ResearchGate publication ID23287716

P2093author name stringTahiro Shin
Stephen D Miller
Lieping Chen
Samantha L Bailey
Bettina Schreiner
P2860cites workB7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretionQ22010866
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cellsQ24291070
Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine productionQ24292957
Human IL-17: a novel cytokine derived from T cellsQ24304404
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) miceQ24670319
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interactionQ24673269
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activationQ24675931
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokinesQ24678115
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptorQ28144319
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient miceQ28201627
PD-L2 is a second ligand for PD-1 and inhibits T cell activationQ28202471
Expression of programmed death 1 ligands by murine T cells and APCQ28214264
Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosusQ28250589
The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cellsQ28260674
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytesQ28282689
Restoring function in exhausted CD8 T cells during chronic viral infectionQ28289222
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationQ29547525
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availabilityQ30480631
Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosisQ33835268
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivoQ34049368
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12Q34145393
PD-1 inhibits antiviral immunity at the effector phase in the liverQ34535179
Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitisQ34535189
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cellsQ34578170
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitisQ34593300
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responsesQ34650346
Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptorQ35111360
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.Q36228158
Tissue expression of PD-L1 mediates peripheral T cell tolerance.Q36228541
Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitisQ36365105
B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.Q36370918
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptorQ36376676
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responsesQ36402989
Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejectionQ36441358
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.Q36457107
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infectionQ36737159
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cellsQ36986702
Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide productionQ40395261
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.Q40453661
Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand.Q40460778
NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells.Q40493871
B7 family molecules are favorably positioned at the human maternal-fetal interfaceQ40668007
Exacerbations of multiple sclerosis in patients treated with gamma interferonQ40797798
Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitisQ40814343
B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosisQ44822884
Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected miceQ45740050
Peripheral tolerance induction using ethylenecarbodiimide-fixed APCs uses both direct and indirect mechanisms of antigen presentation for prevention of experimental autoimmune encephalomyelitisQ47581510
B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.Q47926434
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responsesQ48186068
The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous systemQ48554549
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.Q48974951
Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Q49014751
Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).Q52519041
CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.Q53015646
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.Q53722655
T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination.Q53897545
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.Q53974447
Suppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells.Q54702814
B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanismQ56903535
CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitisQ56905834
Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAEQ57042714
Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAEQ71457188
Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitisQ73330348
Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysisQ79209903
Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNFQ82459138
Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitisQ82732353
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)2706-2717
P577publication date2008-10-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titlePD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.
P478volume38

Reverse relations

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