Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy

scientific article published on 02 June 2009

Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/JC.2009-0309
P932PMC publication ID2730867
P698PubMed publication ID19491224
P5875ResearchGate publication ID26261794

P50authorKarel PacakQ64821278
P2093author name stringJohn C Morris
Raj K Puri
Lucia Martiniova
Irina A Lubensky
Ronald R de Krijger
Bharat H Joshi
Toshio Fujisawa
Abdel G Elkahloun
Edwin W Lai
Pamela Leland
Ritika Dogra
P2860cites workThe IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptorQ71968340
Identification of potential gene markers and insights into the pathophysiology of pheochromocytoma malignancyQ81317022
Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapyQ28257229
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosisQ28285105
Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytomaQ34142563
Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedsideQ35597936
Improved anti-tumor activity and safety of interleukin-13 receptor targeted cytotoxin by systemic continuous administration in head and neck cancer xenograft model.Q36088101
Current progress and future challenges in the biochemical diagnosis and treatment of pheochromocytomas and paragangliomasQ36467140
Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapyQ36478656
Role of interleukin-13 in cancer, pulmonary fibrosis, and other T(H)2-type diseasesQ36617133
An overview of pheochromocytoma: history, current concepts, vagaries, and diagnostic challengesQ36652761
Clinical review: Current treatment of malignant pheochromocytomaQ36729834
Heterogeneity in interleukin-13 receptor expression and subunit structure in squamous cell carcinoma of head and neck: differential sensitivity to chimeric fusion proteins comprised of interleukin-13 and a mutated form of Pseudomonas exotoxin.Q38288231
Evidence that IL-13R alpha2 chain in human glioma cells is responsible for the antitumor activity mediated by receptor-directed cytotoxin therapyQ38327826
Optimization of expression and purification of two biologically active chimeric fusion proteins that consist of human interleukin-13 and Pseudomonas exotoxin in Escherichia coli.Q40473122
Specifically targeted killing of interleukin-13 (IL-13) receptor-expressing breast cancer by IL-13 fusion cytotoxin in animal model of human disease.Q40585494
Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathwayQ41011905
Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cellsQ41090719
Gene expression profiling of benign and malignant pheochromocytomaQ41443242
Interleukin-13 receptor as a unique target for anti-glioblastoma therapyQ43567315
Potent antitumor activity of IL-13 cytotoxin in human pancreatic tumors engineered to express IL-13 receptor alpha2 chain in vivoQ45862963
Conditional Pten knock-out mice: a model for metastatic phaeochromocytomaQ46163793
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study GroupQ46232239
Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice.Q52826566
ErbB-2 induces bilateral adrenal pheochromocytoma formation in mice.Q53536726
Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas.Q55475919
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
phaeochromocytomaQ536269
malignant pheochromocytomaQ60195344
overexpressionQ61643320
P304page(s)2952-2957
P577publication date2009-06-02
P1433published inThe Journal of Clinical Endocrinology and MetabolismQ3186902
P1476titleOverexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy
P478volume94