Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

scientific article published on 30 June 2009

Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand is …
instance of (P31):
scholarly articleQ13442814

External links are
P8978DBLP publication IDjournals/neuroimage/TerryLZHFLTSPFMHPHI09
P356DOI10.1016/J.NEUROIMAGE.2009.06.059
P932PMC publication ID2730982
P698PubMed publication ID19573609
P5875ResearchGate publication ID26337127

P50authorChrister HalldinQ62559921
P2093author name stringJeih-San Liow
Robert B Innis
Victor W Pike
Jussi Hirvonen
Sami S Zoghbi
Cheryl L Morse
Johannes T Tauscher
Christian C Felder
Alicja Lerner
John M Schaus
Lee Phebus
Jinsoo S Hong
Garth E Terry
Amanda G Farris
P2860cites work[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptorQ24680848
Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject BrainQ25855787
International Union of Pharmacology. XXVII. Classification of cannabinoid receptorsQ29616832
Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophreniaQ33932087
The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brainQ34613459
Consensus nomenclature for in vivo imaging of reversibly binding radioligandsQ34630958
Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodentsQ36775155
Isolation and expression of a mouse CB1 cannabinoid receptor gene. Comparison of binding properties with those of native CB1 receptors in mouse brain and N18TG2 neuroblastoma cells.Q36847055
Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imagingQ36984451
Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brainQ42451047
Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian populationQ44642090
End of the line for cannabinoid receptor 1 as an anti-obesity target?Q46222437
Evaluation of ultrafiltration for the free-fraction determination of single photon emission computed tomography (SPECT) radiotracers: beta-CIT, IBF, and iomazenilQ48097281
Relationship of type 1 cannabinoid receptor availability in the human brain to novelty-seeking temperamentQ48299867
PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat.Q48357921
Effects of temporal sampling, glucose metabolic rates, and disruptions of the blood-brain barrier on the FDG model with and without a vascular compartment: studies in human brain tumors with PET.Q48361727
11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptorsQ48406514
Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo.Q48568603
Kinetics of binding to opiate receptors in vivo predicted from in vitro parametersQ48646605
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptorsQ48966515
Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET.Q53447148
P4510describes a project that usespositron emission tomographyQ208376
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpositron emission tomographyQ208376
cannabinoid receptorQ421237
cannabinoidsQ422936
CNR2Q17907844
P304page(s)362-370
P577publication date2009-06-30
P1433published inNeuroImageQ1981225
P1476titleQuantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
P478volume48

Reverse relations

cites work (P2860)
Q4256426818F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study.
Q36368922A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates
Q84750734Abstracts of the Ninth International Symposium on Functional Neuroreceptor Mapping of the Living Brain. August 9-11, 2012
Q47120434Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors
Q42741921Approaches to quantify radioligands that wash out slowly from target organs
Q48585422Automated one-step radiosynthesis of the CB1 receptor imaging agent [(18) F]MK-9470.
Q34044002Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography
Q38132167Cannabis, a complex plant: different compounds and different effects on individuals
Q36604291Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier isotopologues
Q38124448Comorbid substance use disorder in schizophrenia: a selective overview of neurobiological and cognitive underpinnings
Q42156717Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase
Q38182651Dyskinesias in Parkinson's disease: views from positron emission tomography studies
Q57166606Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies
Q30687668Endocannabinoid signaling in the etiology and treatment of major depressive illness
Q48499558Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach.
Q41288205Guidelines to PET measurements of the target occupancy in the brain for drug development.
Q33833784Image-derived input function for human brain using high resolution PET imaging with [C](R)-rolipram and [C]PBR28
Q34382594Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands
Q27321190Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: assessment of kinetic analysis methods, test-retest reproducibility, and gender differences
Q37621131Impact of cannabis use on prefrontal and parietal cortex gyrification and surface area in adolescents and emerging adults
Q36267474Improved models for plasma radiometabolite correction and their impact on kinetic quantification in PET studies
Q37360865In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors
Q34278947In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse.
Q43150645Influence of chronic nicotine administration on cerebral type 1 cannabinoid receptor binding: an in vivo micro-PET study in the rat using [18F]MK-9470.
Q40670083Involvement of the endocannabinoid system in reward processing in the human brain
Q44697227Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain
Q36655387Mapping human brain fatty acid amide hydrolase activity with PET.
Q29248766Molecular Imaging Markers to Track Huntington’s Disease Pathology
Q34904406N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors
Q30834004Neuroimaging in Huntington's disease
Q42369736PET Molecular Imaging Research of Levodopa-Induced Dyskinesias in Parkinson's Disease
Q47303206Pharmacokinetics of the cannabinoid receptor ligand [18 F]MK-9470 in the rat brain - Evaluation of models using microPET.
Q45585427Pharmacological characterization of the cannabinoid CB1 receptor PET ligand ortholog, [3H]MePPEP
Q45319384Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project
Q35757921Poorer frontolimbic white matter integrity is associated with chronic cannabis use, FAAH genotype, and increased depressive and apathy symptoms in adolescents and young adults
Q36162168Positron emission tomography shows elevated cannabinoid CB1 receptor binding in men with alcohol dependence
Q48473239Preclinical evaluation and quantification of [¹⁸F]MK-9470 as a radioligand for PET imaging of the type 1 cannabinoid receptor in rat brain
Q43091758Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR.
Q38028657Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time
Q37591594Retest imaging of [11C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans
Q53151112Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model.
Q48502246Synthesis and preclinical evaluation of [¹⁸F]FCHC for neuroimaging of fatty acid amide hydrolase
Q38166976Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type-1 receptors
Q34812954Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.
Q64229781The Endocannabinoid System and Cannabidiol's Promise for the Treatment of Substance Use Disorder
Q37621168The impact of ADHD persistence, recent cannabis use, and age of regular cannabis use onset on subcortical volume and cortical thickness in young adults
Q42948746Type 1 cannabinoid receptor mapping with [18F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism
Q47566341Using molecular imaging to understand early schizophrenia-related psychosis neurochemistry: a review of human studies.
Q58576516[--C]-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1-indole-2-carboxamide ([C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey
Q47565244[Carboxyl-11 C]Labelling of Four High-Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography.
Q34269852[¹²⁵I]SD-7015 reveals fine modalities of CB₁ cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's disease