Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin

scientific article published on 06 October 2016

Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI.INSIGHT.88549
P932PMC publication ID5053152
P698PubMed publication ID27734029

P2093author name stringKathryn A O'Donnell
Gail E Tomlinson
Robert E Hammer
Dinesh Rakheja
Yidong Chen
Milton J Finegold
Sarah A Comerford
Dolores Lopez-Terrada
Hima Bansal
Elizabeth A Hinnant
Shawn Klapproth
P2860cites workCancer genome landscapesQ22242276
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Developmental context determines latency of MYC-induced tumorigenesisQ24794847
Strategically targeting MYC in cancerQ26747745
Dedifferentiation and reprogramming: origins of cancer stem cellsQ26826876
Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposiumQ26828479
Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosisQ27478444
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagyQ27685461
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisQ28242612
Lineage dependency and lineage-survival oncogenes in human cancerQ28253671
The epidemiology of hepatoblastomaQ28268711
The β-catenin destruction complexQ28279593
Fields and field cancerization: the preneoplastic origins of cancer: asymptomatic hyperplastic fields are precursors of neoplasia, and their progression to tumors can be tracked by saturation density in cultureQ28303776
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancerQ28387975
Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistanceQ28505114
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesisQ33344462
Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing AirwayQ33569956
Gene expression analysis via multidimensional scaling.Q51887994
Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: drastic change of EpCAM expression during liver development.Q51932551
Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma.Q52065383
Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.Q53326694
Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.Q53391138
Oncogene-induced liver neoplasia in transgenic mice.Q53515079
Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex.Q54346071
Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver CancerQ56762983
DNA excision in liver by an albumin-Cre transgene occurs progressively with ageQ61203358
Dynamic expression pattern of the myc protooncogene in midgestation mouse embryosQ69937778
Transient expression of bile-duct-specific cytokeratin in fetal mouse hepatocytesQ71655393
Hepatomegaly in transgenic mice expressing an oncogenic form of beta-cateninQ73773421
III. Intracellular signaling in response to toxic liver injuryQ77551222
Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21Q81892355
Over-expression of SERPINB3 in hepatoblastoma: a possible insight into the genesis of this tumour?Q84518605
Field cancerization in non-small cell lung cancer: implications in disease pathogenesisQ34272221
NRF2 and cancer: the good, the bad and the importance of context.Q34289003
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancerQ34357796
Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancerQ34377430
Antioxidants accelerate lung cancer progression in miceQ34400895
Increased risk of hepatoblastoma among immature children with a lower birth weight.Q34749769
Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: a report from the Children's Oncology GroupQ34871284
Distinct thresholds govern Myc's biological output in vivoQ34897529
Cited1 deficiency suppresses intestinal tumorigenesis.Q34917145
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targetsQ36104399
Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.Q36348318
Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3.Q36928964
B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liverQ36999867
The cytoprotective Nrf2 transcription factor controls insulin receptor signaling in the regenerating liverQ37138951
The emerging role of the Nrf2-Keap1 signaling pathway in cancerQ37271797
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinomaQ37284612
Beta-catenin activation promotes liver regeneration after acetaminophen-induced injuryQ37316489
A novel significance score for gene selection and ranking.Q37642326
Chemotherapeutic approaches for newly diagnosed hepatoblastoma: past, present, and future strategiesQ38014796
Phenotypic diversity in experimental hepatomas: the concept of partially blocked ontogeny. The 10th Walter Hubert LectureQ38593507
The genomic landscape of hepatoblastoma and their progenies with HCC-like featuresQ38964756
β-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastomaQ38993024
Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumorQ39819929
Cancer incidence among children and adolescents in the United States, 2001-2003.Q40085106
Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300.Q40867085
Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver.Q41660129
Developmental appearance of ammonia-metabolizing enzymes in prenatal murine liverQ41668561
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling.Q42067728
Trans-ancestry mutational landscape of hepatocellular carcinoma genomesQ42182370
Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice.Q42207663
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.Q42281692
Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.Q42545193
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating CellsQ42716243
Oxidative stress in very low birth weight infants as measured by urinary 8-OHdG.Q43985458
Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 miceQ44880248
Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.Q47991283
A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancerQ48225584
Trends in childhood cancer incidence in the U.S. (1992-2004).Q51111080
Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis.Q51768533
Activated NOTCH2 is overexpressed in hepatoblastomas: an immunohistochemical study.Q51865266
P4510describes a project that usesImageJQ1659584
P433issue16
P921main subjecthepatoblastomaQ1607658
P304page(s)e88549
P577publication date2016-10-06
P1433published inJCI insightQ27727187
P1476titleHepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin
P478volume1

Reverse relations

cites work (P2860)
Q92922103Animal Modeling of Pediatric Liver Cancer
Q64105137Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations
Q97426639Hepatoblastoma: current knowledge and promises from preclinical studies
Q41670848Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Q50207061Molecular classification of hepatoblastoma and prognostic value of the HB 16-gene signature.
Q91791204Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/β-Catenin-Dependent and Wnt/β-Catenin-Independent Signaling Networks in the Human Liver Cancer
Q90227916The Emerging Roles of Cancer Stem Cells and Wnt/Beta-Catenin Signaling in Hepatoblastoma
Q33608524c-MYC-Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease.

Search more.