A simple LC-MS/MS method for determination of kynurenine and tryptophan concentrations in human plasma from HIV-infected patients

scientific article published on June 2013

A simple LC-MS/MS method for determination of kynurenine and tryptophan concentrations in human plasma from HIV-infected patients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4155/BIO.13.74
P932PMC publication ID3830928
P698PubMed publication ID23742309

P2093author name stringYong Huang
Peter W Hunt
Alexander Louie
Qiyun Yang
Winnie Gee
Connie Xu
Nicholas Massenkoff
P2860cites workThe indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cellsQ28744405
Generic approach to validation of small-molecule LC-MS/MS biomarker assaysQ33748826
Endogenous kynurenines as targets for drug discovery and developmentQ34156448
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV diseaseQ34555620
Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.Q34655953
How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation.Q36789448
Indoleamine-2, 3-dioxygenase and other interferon-gamma-mediated pathways in patients with human immunodeficiency virus infectionQ36789452
Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assaysQ36801534
Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography-tandem mass spectrometryQ39461017
Simultaneous measurement of tryptophan and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometryQ39994236
Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaquesQ43699872
More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC.Q43893230
Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infectionQ44128933
Integration of atazanavir into an existing liquid chromatography UV method for protease inhibitors: validation and applicationQ44208340
Quantitation of endogenous analytes in biofluid without a true blank matrixQ44638305
Simultaneous determination of tryptophan and kynurenine in plasma samples of children patients with Kawasaki disease by high-performance liquid chromatography with programmed wavelength ultraviolet detection.Q46036985
Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometryQ46065776
A proposal for comparing methods of quantitative analysis of endogenous compounds in biological systems by using the relative lower limit of quantification (rLLOQ).Q46096351
Plasma tryptophan, kynurenine and 3-hydroxykynurenine measurement using automated on-line solid-phase extraction HPLC-tandem mass spectrometry.Q46131757
Matrix effect and recovery terminology issues in regulated drug bioanalysisQ46828138
Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.Q47636202
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.Q48679497
Fit-for-purpose method development and validation for successful biomarker measurement.Q50743553
Simultaneous measurement of serum tryptophan and kynurenine by HPLCQ61906305
Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine: method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of aQ73692306
Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patientsQ74468910
Simultaneous determination of tryptophan, kynurenine and 5-hydroxytryptamine by HPLC: Application in uremic patients undergoing hemodialysisQ82531240
Simultaneous determination of urinary tryptophan, tryptophan-related metabolites and creatinine by high performance liquid chromatography with ultraviolet and fluorimetric detectionQ84797579
Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: A study of ion suppressionQ86676053
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
P304page(s)1397-1407
P577publication date2013-06-01
P1433published inBioanalysisQ18616741
P1476titleA simple LC-MS/MS method for determination of kynurenine and tryptophan concentrations in human plasma from HIV-infected patients
P478volume5

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cites work (P2860)
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Q37317771Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection
Q36219873CD4/CD8 Ratio and KT Ratio Predict Yellow Fever Vaccine Immunogenicity in HIV-Infected Patients
Q39356675Chromatographic analysis of tryptophan metabolites.
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Q59797360Determination of Tryptophan and Its Major Metabolites in Fluid from the Anterior Chamber of the Eye in Diabetic Patients with Cataract by Liquid Chromotography Mass Spectrometry (LC-MS/MS)
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Q36033944Development of simultaneous analysis of tryptophan metabolites in serum and gastric juice - an investigation towards establishing a biomarker test for gastric cancer diagnosis
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Q89286789Gentiopicroside abrogates lipopolysaccharide-induced depressive-like behavior in mice through tryptophan-degrading pathway
Q35648710Gut epithelial barrier and systemic inflammation during chronic HIV infection
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Q41920878HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution
Q91868236High Kynurenine:Tryptophan Ratio Is Associated With Liver Fibrosis in HIV-Monoinfected and HIV/Hepatitis C Virus-Coinfected Women
Q37047893Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans
Q54231167Mass spectrometric measurement of urinary kynurenine-to-tryptophan ratio in children with and without urinary tract infection.
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Q57181096Simultaneous determination of tryptophan and its 31 catabolites in mouse tissues by polarity switching UHPLC-SRM-MS
Q99551285Solvent front position extraction with semi-automatic device as a powerful sample preparation procedure to quantitatitation of tryptophan in human plasma
Q36167122The Kynurenine Pathway of Tryptophan Catabolism and AIDS-Associated Kaposi Sarcoma in Africa
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Q92058253Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation
Q64112615Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts

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