Losartan protects liver against ischaemia/reperfusion injury through PPAR-γ activation and receptor for advanced glycation end-products down-regulation

scientific article published on July 2013

Losartan protects liver against ischaemia/reperfusion injury through PPAR-γ activation and receptor for advanced glycation end-products down-regulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BPH.12229
P932PMC publication ID3831716
P698PubMed publication ID23647130

P2093author name stringSun-Mee Lee
Eun-Ji Koh
Seong-Jin Yoon
P2860cites workDifferences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.Q53594506
Are angiotensin II receptor antagonists useful strategies in steatotic and nonsteatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?Q54500904
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Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinasesQ73319924
Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodentQ73939856
Beneficial effects of losartan on vascular injury induced by advanced glycosylation end products and their receptors in spontaneous hypertension ratsQ80287063
Protective effects of peroxisome proliferator-activated receptor gamma ligand on apoptosis and hepatocyte growth factor induction in renal ischemia-reperfusion injuryQ80714863
Telmisartan, an angiotensin II type 1 receptor blocker, inhibits advanced glycation end-product (AGE)-induced monocyte chemoattractant protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome proliferator-acQ80793721
The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signalingQ95414191
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PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In VitroQ28146187
Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end productsQ28505279
Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stressQ28512203
Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury modelQ28574607
Fat and beyond: the diverse biology of PPARgammaQ29615416
Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injuryQ31837343
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Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulationQ34086987
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Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytesQ35612987
Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shockQ36049326
RAGE and modulation of ischemic injury in the diabetic myocardiumQ36756482
Advanced glycation end products (AGEs) and their involvement in liver diseaseQ37160903
Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependentQ37331860
Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damageQ37822830
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Losartan inhibits LPS-induced inflammatory signaling through a PPARgamma-dependent mechanism in human THP-1 macrophagesQ39699893
Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonistQ40281445
The acute phase response is associated with retinoid X receptor repression in rodent liverQ41728097
Thiazolidinediones reduce endothelial expression of receptors for advanced glycation end productsQ42468287
Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activityQ42829351
Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in ratsQ45045433
Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in miceQ46846209
Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusionQ46873543
Importance of peroxisome proliferator-activated receptor-gamma in hepatic ischemia/reperfusion injury in miceQ46951016
Effect of angiotensin II and bradykinin inhibition in rat reduced-size liver transplantationQ47194416
Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in miceQ47214457
The neuroprotective effect of losartan through inhibiting AT1/ASK1/MKK4/JNK3 pathway following cerebral I/R in rat hippocampal CA1 regionQ48323135
Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury.Q51756458
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectlosartanQ410074
reperfusion injuryQ1413991
P304page(s)1404-1416
P577publication date2013-07-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleLosartan protects liver against ischaemia/reperfusion injury through PPAR-γ activation and receptor for advanced glycation end-products down-regulation
P478volume169

Reverse relations

cites work (P2860)
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