Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up

scientific article published on 29 July 2008

Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/ANNONC/MDN429
P932PMC publication ID2733118
P698PubMed publication ID18664560
P5875ResearchGate publication ID23135146

P2093author name stringC Sohn
I J Diel
G Bastert
E F Solomayer
F Schuetz
C Gollan
A Jaschke
P2860cites workReduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]Q28195767
Metastasis to bone: causes, consequences and therapeutic opportunitiesQ29614310
Actions of bisphosphonate on bone metastasis in animal models of breast carcinomaQ33970512
The clinical and cost considerations of bisphosphonates in preventing bone complications in patients with metastatic breast cancer or multiple myelomaQ34340400
Preclinical models of bone metastasesQ34360931
Bisphosphonates in the prevention of bone metastases: current evidenceQ34361007
The clinical course of bone metastases from breast cancerQ36027636
Bisphosphonates antagonise bone growth factors' effects on human breast cancer cells survivalQ36670757
Bisphosphonates induce breast cancer cell death in vitroQ40840471
Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trialQ43514162
Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancerQ44083704
Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patientsQ45151602
Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status.Q51557042
Intra-mammary tumor location does not influence prognosis but influences the prevalence of axillary lymph-node metastases.Q52950362
Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastasesQ63966512
Detection of tumor cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasisQ67558785
Clodronate decreases the frequency of skeletal metastases in women with breast cancerQ71899912
Reduction in new metastases in breast cancer with adjuvant clodronate treatmentQ74837359
P433issue12
P921main subjectbreast cancerQ128581
patientQ181600
bone marrowQ546523
P304page(s)2007-2011
P577publication date2008-07-29
P1433published inAnnals of OncologyQ326122
P1476titleAdjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up
P478volume19

Reverse relations

cites work (P2860)
Q35870578A meta-analysis of the antitumor effect and safety of bisphosphonates in the treatment of multiple myeloma
Q36491378A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts.
Q34138399ASCO 2009: What's New in Breast Cancer Therapy?
Q51741445Adjuvant Bisphosphonate Therapy in Postmenopausal Breast Cancer.
Q36491357Adjuvant bisphosphonate treatment for breast cancer: Where are we heading and can the pre-clinical literature help us get there?
Q38007855Adjuvant bisphosphonate treatment for breast cancer: why did something so elegant become so complicated?
Q30982699Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials
Q26781435Adjuvant bisphosphonates in patients with breast cancer: does the potency matter?
Q42603658Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial.
Q36216730Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes
Q38230839Adjuvant zoledronic acid in patients with early breast cancer: final efficacy analysis of the AZURE (BIG 01/04) randomised open-label phase 3 trial
Q37845836Anticancer effect of bisphosphonates: new insights from clinical trials and preclinical evidence.
Q37847341Anticancer evidence for zoledronic acid across the cancer continuum.
Q37812731Antitumor Effects and Anticancer Applications of Bisphosphonates
Q34348233Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay
Q46620695BONUS 5: 5th Annual Bone and The Oncologist New Updates
Q37418042Basic research and clinical applications of bisphosphonates in bone disease: what have we learned over the last 40 years?
Q38147841Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates
Q85183752Bisphosphonate Risks and Benefits: Finding a Balance
Q24203656Bisphosphonates and other bone agents for breast cancer
Q47693752Bisphosphonates and other bone agents for breast cancer.
Q37797755Bisphosphonates as Anticancer Therapy for Early Breast Cancer
Q26795493Bisphosphonates as anticancer agents in early breast cancer: preclinical and clinical evidence
Q42874080Bisphosphonates in adjuvant therapy of breast cancer
Q21132670Bisphosphonates in the adjuvant setting of breast cancer therapy--effect on survival: a systematic review and meta-analysis
Q36963360Bisphosphonates in the adjuvant treatment of young women with breast cancer: the estrogen rich is a poor candidate!
Q35750472Bone Health in Patients with Breast Cancer: Recommendations from an Evidence-Based Canadian Guideline
Q39157481Bone Modifier Use as Adjuvant Therapy for Early Breast Cancer
Q28081996Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma
Q53805388Bone marrow versus sentinel lymph node involvement in breast cancer: a comparison of early hematogenous and early lymphatic tumor spread.
Q46277856Bone microenvironment-mediated resistance of cancer cells to bisphosphonates and impact on bone osteocytes/stem cells
Q43712545Bone mineral density is a prognostic factor for postmenopausal caucasian women with breast cancer
Q37337487Bone targeted treatments in cancer - The story so far
Q64980540Bone-Modifying Agents in Early-Stage and Advanced Breast Cancer.
Q28081294Bone-Targeted Therapy
Q34209663Breast Cancer 2012 - New Aspects
Q34939979Breast cancer at bone metastatic sites: recent discoveries and treatment targets.
Q35750453Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
Q26774808Circulating tumor cells in breast cancer
Q44635510Demographic and clinico-pathological characteristics of breast cancer patients with history of oral alendronate use.
Q37965768Denosumab and the current status of bone-modifying drugs in breast cancer
Q36925557Different prognostic value of circulating and disseminated tumor cells in primary breast cancer: Influence of bisphosphonate intake?
Q39022352Disseminated tumor cells as a monitoring tool for adjuvant therapy in patients with primary breast cancer
Q64903290Disseminated tumour cells in bone marrow are the source of cancer relapse after therapy.
Q36491529Does estrogen play a role in response to adjuvant bone-targeted therapies?
Q38173736Dormancy in breast cancer
Q36491459Effect of adjuvant bisphosphonates on disease-free survival in early breast cancer: Retrospective analysis results in an unselected single-center cohort
Q48185674Evaluation of the prognostic significance of disseminated tumor cells in the bone marrow of primary, non-metastatic breast cancer patients after a 7-year follow-up.
Q58795240Exposure to alendronate is associated with a lower risk of bone metastases in osteoporotic women with early breast cancer
Q34023727Future directions of bone-targeted therapy for metastatic breast cancer
Q92607493Guideline adherence in bone-targeted treatment of cancer patients with bone metastases in Germany
Q36283738Importance of antiresorptive therapies for patients with bone metastases from solid tumors
Q33587199Influence of zoledronic acid on disseminated tumor cells in bone marrow and survival: results of a prospective clinical trial
Q35653826Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game
Q37742180Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG
Q53376377Mechanisms and pathways of bone metastasis: challenges and pitfalls of performing molecular research on patient samples.
Q36668047Mitochondrial permeability transition pore as a selective target for anti-cancer therapy
Q34617936NCCN Task Force Report: Bone Health in Cancer Care
Q37917774New perspectives on zoledronic acid in breast cancer: potential augmentation of anticancer immune response
Q37355487Optimal management of bone metastases in breast cancer patients
Q35583788Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases.
Q34049239Oral bisphosphonate use and breast cancer incidence in postmenopausal women
Q33447971Potential antitumor effects of nitrogen-containing bisphosphonate in hormone receptor negative breast cancer patients with bone metastases
Q55030407Practical consensus recommendaton for adjuvant bone-modifying agents in breast cancer.
Q35750652Prevention and Treatment of Bone Metastases in Breast Cancer
Q35667318Prevention of Bone Metastases in Breast Cancer Patients. Therapeutic Perspectives
Q34613485Prevention of bone metastases and management of bone health in early breast cancer.
Q34967135Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells
Q37094622Prognostic factors for patients with bone-only metastasis in breast cancer
Q37483543Retrospective analysis of antitumor effects of zoledronic acid in breast cancer patients with bone-only metastases
Q34127953Reverse-phase protein array for prediction of patients at low risk of developing bone metastasis from breast cancer.
Q34042715Targeted and Osteo-Oncologic Treatment in Early Breast Cancer: What Is State-of-the-Art and What Might Become so within the Next 5 Years?
Q34115304Targeting mitochondria for cancer therapy
Q37777488The Evolving Role of Bone-Conserving Therapy in Patients With Breast Cancer
Q36187063The Frequency of and Risk Factors for the Use of Bisphosphonates in the Adjuvant Setting of Primary Breast Cancer in Germany
Q44503403The HER2 status of disseminated tumor cells in the bone marrow of early breast cancer patients is independent from primary tumor and predicts higher risk of relapse
Q37808268The crossover of bisphosphonates to cancer therapy
Q37690073The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy
Q37944154The role of antiresorptive therapies in improving patient care in early and metastatic breast cancer
Q34145863The role of zoledronic acid in the adjuvant treatment of breast cancer: current perspectives
Q37800183The use of bisphosphonates in cancer treatment
Q54577990Trastuzumab clears HER2/neu-positive isolated tumor cells from bone marrow in primary breast cancer patients.
Q35667196Treatment and Prevention of Bone Metastases from Breast Cancer: A Comprehensive Review of Evidence for Clinical Practice
Q34896573Treatment of osteoporosis and reduction in risk of invasive breast cancer in postmenopausal women with raloxifene
Q37401841Treatment options for breast cancer and bone metastases
Q46904792Turning ecology and evolution against cancer
Q37807047Understanding and Optimizing Bone Health in Breast Cancer
Q30318610Update 2010 of the German AGO Recommendations for the Diagnosis and Treatment of Early and Metastatic Breast Cancer - Chapter A: Surgery, Pathology and Prognostic Factors, Adjuvant and Neoadjuvant Therapy, Adjuvant Radiotherapy
Q34122791Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma
Q58694739Zoledronic acid in the management of mesothelioma - a feasibility study (Zol-A Trial): study protocol for a randomised controlled trial
Q37960410Zoledronic acid in the treatment of early-stage breast cancer: is there a final verdict?
Q37909355Zoledronic acid: multiplicity of use across the cancer continuum

Search more.