Non-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies

scientific article published on 31 October 2007

Non-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10616-007-9103-2
P8608Fatcat IDrelease_eruxqysxzbf5rkjtvvxpyrpxeu
P932PMC publication ID2104554
P698PubMed publication ID19003000
P5875ResearchGate publication ID23467447

P2093author name stringYutaka Kanda
Kenya Shitara
Mitsuo Satoh
Shigeru Iida
Naoko Yamane-Ohnuki
Rinpei Niwa
Ryosuke Nakano
Akira Okazaki
Katsuhiro Mori
Reiko Kuni-Kamochi
Toyohide Shinkawa
Harue Imai-Nishiya
Akihito Natsume
P2860cites workThe relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus.Q54791103
Combination immunotherapy with rituximab and interleukin 2 in patients with relapsed or refractory follicular non-Hodgkin's lymphomaQ58415142
Monoclonal antibody successes in the clinicQ61163248
Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2Q62604209
Systematic fractionation of oligosaccharides of human immunoglobulin G by serial affinity chromatography on immobilized lectin columnsQ69437692
Structural and numerical variations of the carbohydrate moiety of immunoglobulin GQ71620208
Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodiesQ72228246
Mechanisms of G-CSF- or GM-CSF-stimulated tumor cell killing by Fc receptor-directed bispecific antibodiesQ73551191
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa geneQ77535970
Association of serum Rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphomaQ77565327
GlycobiologyQ22255657
Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicityQ30835165
CpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populationsQ33193071
Profiling analysis of oligosaccharides in antibody pharmaceuticals by capillary electrophoresisQ33208374
Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancerQ33598660
Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).Q33730975
Mechanism of action of anti-HER2 monoclonal antibodiesQ34346097
Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicityQ34346238
Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-->6fucosyltransferase.Q34406765
Engineered antibody Fc variants with enhanced effector functionQ34424958
Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodiesQ34574834
The ErbB receptor family: a therapeutic target for cancerQ34583857
Immunostimulatory CpG oligodeoxynucleotides and antibody therapy of cancerQ35206358
Clinical Experience with Trastuzumab (Herceptin)Q35583405
Rituximab (Rituxan/MabThera): the first decade (1993-2003).Q35611848
History of antibody therapy for non-Hodgkin's lymphomaQ35622590
Glycosylation of recombinant antibody therapeuticsQ36132495
Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded antibody comprising a single-chain antibody linked the antibody constant regionQ38319734
IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharidesQ38320052
Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen densityQ38328896
Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 Is independent of FcgammaRIIIa functional polymorphismQ38336117
Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and FcgammaRIIIaQ38343329
Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC.Q40293476
High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G.Q40384899
Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphomaQ40562102
The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicityQ40690773
Comparability testing of a humanized monoclonal antibody (Synagis) to support cell line stability, process validation, and scale-up for manufacturingQ40903347
Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphomaQ44802891
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.Q46117208
Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship.Q47254808
Rituximab-mediated depletion of cynomolgus monkey B cells in vitro in different matrices: possible inhibitory effect of IgG.Q47275450
Upping the ante on antibodies.Q51358173
Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA.Q51591345
Nonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high binding to FcgammaRIIIa.Q51807927
P433issue2-3
P921main subjectantibodyQ79460
P304page(s)109-114
P577publication date2007-10-31
P1433published inCytotechnologyQ15752151
P1476titleNon-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies
P478volume55

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cites work (P2860)
Q46242617A framework for real-time glycosylation monitoring (RT-GM) in mammalian cell culture
Q38849069A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation
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