Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

scientific article published on 13 September 2016

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/MTNA.2016.68
P932PMC publication ID5056992
P698PubMed publication ID27623445

P50authorPieter R. CullisQ88255217
P2093author name stringYan Liu
Genc Basha
Haitang Wang
Andrew Cottle
Mina Ordobadi
Wilder R Scott
P2860cites workOsteocyte control of bone formation via sclerostin, a novel BMP antagonistQ24300347
Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balanceQ24318937
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing proteinQ24536172
IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samplesQ27333953
Progress toward in vivo use of siRNAs-IIQ28255877
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formationQ28269067
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosisQ28302443
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy.Q33901933
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanismsQ34025149
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Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trialQ34375398
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ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in miceQ35370268
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA.Q36234343
Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response.Q36293364
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivoQ36315291
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recyclingQ37270647
Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid NanoparticlesQ37489356
Developing siRNA therapies to address osteoporosisQ38151734
Emerging therapeutic targets for osteoporosis treatmentQ38207147
Mouse embryonic fibroblasts (MEF) exhibit a similar but not identical phenotype to bone marrow stromal stem cells (BMSC).Q38331808
Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.Q39913293
The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes.Q42031050
The Business of RNAi Therapeutics in 2012Q42212141
Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male ratsQ42966206
Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors.Q44128390
The natural history of sclerosteosisQ46647658
Safety and efficacy of RNAi therapy for transthyretin amyloidosisQ46836193
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on sizeQ47348224
Romosozumab in postmenopausal women with low bone mineral density.Q50481558
Van Buchem disease: lifetime evolution of radioclinical featuresQ50482303
Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway.Q51887855
A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy.Q54326868
Primary mouse embryonic fibroblasts: A model of mesenchymal cartilage formationQ57129782
The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouseQ81319561
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bonesQ84033150
Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administrationQ85683734
P4510describes a project that usesImageJQ1659584
P433issue9
P921main subjectnanoparticleQ61231
P304page(s)e363
P577publication date2016-09-13
P1433published inMolecular Therapy. Nucleic acidsQ27724110
P1476titleLipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo
P478volume5