The advancing field of cell-based therapy: insights and lessons from clinical trials.

scientific article published on 10 October 2013

The advancing field of cell-based therapy: insights and lessons from clinical trials. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1161/JAHA.113.000338
P932PMC publication ID3835242
P698PubMed publication ID24113326

P50authorIvonne Hernandez SchulmanQ58875451
P2093author name stringJoshua M Hare
Viky Y Suncion
Kartik S Telukuntla
P2860cites workIntracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial InfarctionQ22250889
Stem cell treatment for acute myocardial infarctionQ24203736
Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biologyQ26858965
Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac diseaseQ26865070
Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemiaQ28582868
Mesenchymal stem cells in health and diseaseQ29614296
Mesenchymal stem cells reside in virtually all post-natal organs and tissuesQ29617740
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trialQ29620043
RETRACTED: Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trialQ29620044
Adult cardiac stem cells are multipotent and support myocardial regenerationQ29620122
Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarctionQ30496413
Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiationQ30523741
Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: combined consequences for cell therapy in older recipientsQ30909219
Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart diseaseQ33200016
Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trialQ33263365
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac functionQ33863225
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation.Q34010010
Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trialQ38452816
Human versus porcine mesenchymal stromal cells: phenotype, differentiation potential, immunomodulation and cardiac improvement after transplantationQ41948638
Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodelingQ42226249
Stem cells and myocardial regeneration: cooperation wins over competitionQ42917118
What is the oncologic risk of stem cell treatment for heart disease?Q43203972
Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failureQ44270472
Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow.Q45859658
Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarctionQ46259595
Assessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imagingQ46553132
A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cellsQ46833564
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.Q48414650
Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarctionQ48619654
The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro.Q50684064
Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation.Q53171235
CD34(+) cell infusion after ST elevation myocardial infarction is associated with improved perfusion and is dose dependent.Q53254720
Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1.Q54465293
Cell-based therapy for myocardial repair in patients with acute myocardial infarction: Rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI)Q54806428
Cardiopoietic Stem Cell Therapy in Heart FailureQ57779306
Reparative Effects of Allogeneic Mesenchymal Precursor Cells Delivered Transendocardially in Experimental Nonischemic CardiomyopathyQ58865316
Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populationsQ59696056
Regenerating functional myocardium: Improved performance after skeletal myoblast transplantationQ61776512
Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction. SOLVD InvestigatorsQ70508775
Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic functionQ74211099
Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effectsQ74341231
HLA expression and immunologic propertiesof differentiated and undifferentiated mesenchymal stem cellsQ79149793
CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cellsQ79317344
Adipose tissue stromal cells transplantation in rats of acute myocardial infarctionQ80147613
Isolation and expansion of adult cardiac stem cells from human and murine heartQ80837204
Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarctionQ81435055
T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppressionQ81704121
Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarctionQ82750318
Skeletal myoblasts for cardiac repair: Act II?Q82750332
Rationale and design of the Transendocardial Injection of Autologous Human Cells (bone marrow or mesenchymal) in Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction (TAC-HFT) trial: A randomized, doubleQ83582313
Exogenous basic fibroblast growth factor promotes cardiac stem cell-mediated myocardial regeneration after miniswine acute myocardial infarctionQ83665843
Mixed results for bone marrow–derived cell therapy for ischemic heart diseaseQ85334667
Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI studyQ34063589
Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trialQ34074673
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy.Q34228118
Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trialQ34332467
Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trialQ34467911
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice.Q35050037
Cardiac cell therapy: where we've been, where we are, and where we should be headedQ35144550
Fundamental concepts in myocardial viability assessment revisited: when knowing how much is "alive" is not enoughQ35632156
CT for evaluation of myocardial cell therapy in heart failure: a comparison with CMR imagingQ35632921
Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cellsQ35666637
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cellsQ35799278
Human cardiac stem cellsQ35956924
Cardiovascular magnetic resonance characterization of peri-infarct zone remodeling following myocardial infarctionQ35959779
Cell-based therapy for prevention and reversal of myocardial remodelingQ36176132
Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonanceQ36252910
Stem cells, ageing and the quest for immortality.Q36523915
Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trialQ36603453
Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarctionQ36630155
A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarctionQ36634299
Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trialQ36694346
Is functional improvement after myocardial infarction predicted with myocardial enhancement patterns at multidetector CT?Q36906566
The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regenerationQ36976177
Concise review: the role of clinical trials in deciphering mechanisms of action of cardiac cell-based therapyQ37056280
Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cellsQ37133940
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart diseaseQ37253735
Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity.Q37310724
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac functionQ37355668
Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathyQ37420332
Myocardial infarction and intramyocardial injection models in swineQ37606101
What's new in cardiac cell therapy? Allogeneic bone marrow stromal cells as "universal donor cells".Q37690845
Stem cells for heart failure in the aging heartQ37708148
Multipotent mesenchymal stromal cell therapy and risk of malignanciesQ37975113
Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysisQ38021450
Translational findings from cardiovascular stem cell researchQ38039764
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue5
P921main subjectheart diseaseQ190805
cell transplantationQ65592860
biomedical investigative techniqueQ66648976
P304page(s)e000338
P577publication date2013-10-10
P1433published inJournal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseQ19880670
P1476titleThe advancing field of cell-based therapy: insights and lessons from clinical trials
P478volume2