Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice

scientific article published on 25 September 2008

Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/ATVBAHA.108.172320
P932PMC publication ID2736686
P698PubMed publication ID18818416
P5875ResearchGate publication ID23281829

P50authorKarine ClémentQ62104165
Michèle Guerre-MilloQ124091208
P2093author name stringJie Zhang
Jian Liu
Min Yang
Guo-Ping Shi
Bruce D Gelb
Jiusong Sun
Froogh Darakhshan
Tinghu Zhang
Michael A Shi
Gregory Dolgnov
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Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin DQ28214776
Insulin degradation: progress and potentialQ28287093
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectinQ29617865
Inhibition of cathepsin K with lysosomotropic macromolecular inhibitorsQ30702065
Cathepsin K in adipocyte differentiation and its potential role in the pathogenesis of obesityQ33254108
Cathepsin L activity controls adipogenesis and glucose toleranceQ34654358
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient miceQ34967612
Review article: adipocytokines and insulin resistanceQ36286269
Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphismQ36380525
Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient miceQ36791739
Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.Q40661967
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Insulin resistance is mediated by a proteolytic fragment of the insulin receptorQ42823390
Arylaminoethyl amides as novel non-covalent cathepsin K inhibitorsQ44010036
Weight loss reduces adipose tissue cathepsin S and its circulating levels in morbidly obese womenQ46880197
Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.Q47813796
Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradationQ50335753
Extracellular matrix substrata alter adipocyte yield and lipogenesis in primary cultures of stromal-vascular cells from human adipose.Q51722962
Comprehensive transcriptome of proteases and protease inhibitors in vascular cells.Q54625618
Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesisQ57420159
Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patientsQ69554764
Dose-response curves for in vivo insulin sensitivity in individual tissues in ratsQ69885313
Thyroid hormone metabolism in obesityQ74345589
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectglucoseQ37525
glycobiologyQ899224
weight gainQ3403879
P304page(s)2202-2208
P577publication date2008-09-25
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleDeficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice
P478volume28

Reverse relations

cites work (P2860)
Q35605294Adipose tissue remodeling in pathophysiology of obesity
Q51320695An allosteric site enables fine-tuning of cathepsin K by diverse effectors.
Q48348409Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice.
Q33973023Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits
Q35527162Cathepsin K knockout alleviates aging-induced cardiac dysfunction
Q37593416Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy
Q36560578Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction
Q41458755Cathepsin K knockout protects against cardiac dysfunction in diabetic mice
Q38784335Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences
Q37889119Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis
Q35851900Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice
Q51719566Cathepsin S inhibition lowers blood glucose levels in mice.
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Q92846993Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis
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