PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1.

scientific article published on January 2013

PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013NatCo...4.2690S
P6179Dimensions Publication ID1012068290
P356DOI10.1038/NCOMMS3690
P932PMC publication ID3836055
P698PubMed publication ID24162165
P5875ResearchGate publication ID258102669

P2093author name stringZhongxian Jiao
Eun-Mi Hur
Feng-Quan Zhou
Chang-Mei Liu
Wen-Lin Xu
Saijilafu
P2860cites workA SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formationQ22003817
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signalQ24301688
PTEN deletion enhances the regenerative ability of adult corticospinal neuronsQ24625004
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathwayQ24644113
Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injuryQ24794310
Growing the growth cone: remodeling the cytoskeleton to promote axon regenerationQ26829489
A Smad action turnover switch operated by WW domain readers of a phosphoserine codeQ27670475
A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth.Q52196701
Cell biology. GSK-3beta and microtubule assembly in axons.Q54488001
Cellular responses to axotomy and to related proceduresQ68916540
Increased regeneration rate in peripheral nerve axons following double lesions: enhancement of the conditioning lesion phenomenonQ71106453
Time course of the conditioning lesion effect on axonal regenerationQ71128932
c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomyQ73940780
Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivoQ80996402
Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanismQ83986249
Defining the role of mTOR in cancerQ28235431
Regeneration beyond the glial scarQ28239915
Smad transcription factorsQ28284775
The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.Q28583817
The AP-1 transcription factor c-Jun is required for efficient axonal regenerationQ28594782
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinaseQ28628494
GSK-3: Functional Insights from Cell Biology and Animal ModelsQ30472813
Axon regeneration requires a conserved MAP kinase pathway.Q30489631
Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules.Q30499138
Axon regeneration requires coordinate activation of p38 and JNK MAPK pathwaysQ30501903
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling.Q30519558
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinaseQ33298503
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regenerationQ33500892
Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nervesQ34107374
PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons.Q34124806
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancersQ34153121
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signalingQ34212404
Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signallingQ34448693
Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.Q34977773
Genetic dissection of axon regeneration via in vivo electroporation of adult mouse sensory neuronsQ36457585
Recapitulate development to promote axonal regeneration: good or bad approach?Q36581080
The neurodevelopmental implications of PI3K signalingQ37768062
GSK3 signalling in neural developmentQ37774552
Genetic dissection of axon regenerationQ37787426
Neuronal intrinsic mechanisms of axon regeneration.Q37857838
Assembly of a new growth cone after axotomy: the precursor to axon regenerationQ37983990
Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 SignalingQ37985959
GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubulesQ38617811
Axonal regeneration in the rat sciatic nerve: Effect of a conditioning lesion and of dbcAMPQ40105035
c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regenerationQ40803369
Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degenerationQ40947311
Degeneration and regeneration of axons in the lesioned spinal cordQ40980911
Axotomy-induced Smad1 activation promotes axonal growth in adult sensory neurons.Q41767032
Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cellsQ44019938
Axon Outgrowth Enhanced by a Previous Nerve InjuryQ44957651
Raf and akt mediate distinct aspects of sensory axon growthQ45345797
Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS.Q46392215
Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.Q50668696
P407language of work or nameEnglishQ1860
P304page(s)2690
P577publication date2013-01-01
P1433published inNature CommunicationsQ573880
P1476titlePI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1.
P478volume4

Reverse relations

cites work (P2860)
Q273427723D Printed Anatomical Nerve Regeneration Pathways
Q36736180A Controlled Design of Aligned and Random Nanofibers for 3D Bi-functionalized Nerve Conduits Fabricated via a Novel Electrospinning Set-up
Q64116723A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways
Q98303578AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury
Q49311835Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation
Q41928031Akt-independent GSK3 inactivation downstream of PI3K signaling regulates mammalian axon regeneration
Q37496350Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.
Q58555622An In Vitro Model for Conditioning Lesion Effect
Q34702291An in vitro assay to study induction of the regenerative state in sensory neurons
Q51412468Autophagy inhibition in endogenous and nutrient-deprived conditions reduces dorsal root ganglia neuron survival and neurite growth in vitro.
Q38248881Axon plasticity in the mammalian central nervous system after injury
Q89997912BMP signaling downstream of the Highwire E3 ligase sensitizes nociceptors
Q26852511BMP signaling in axon regeneration
Q92692337BMP4/Smad1 Signalling Promotes Spinal Dorsal Column Axon Regeneration and Functional Recovery After Injury
Q38718341Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity.
Q38188439Cell intrinsic control of axon regeneration
Q57169647Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration
Q35472270Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.
Q30252466Delineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targets
Q47401427Depolarization and electrical stimulation enhance in vitro and in vivo sensory axon growth after spinal cord injury
Q60951186Dexmedetomidine Ameliorates the Neurotoxicity of Sevoflurane on the Immature Brain Through the BMP/SMAD Signaling Pathway
Q92826363Effects of siRNA-Mediated Knockdown of GSK3β on Retinal Ganglion Cell Survival and Neurite/Axon Growth
Q38399425Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury
Q58765409Expression and Manipulation of the APC-β-Catenin Pathway During Peripheral Neuron Regeneration
Q28070238Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury
Q35628101Function of cancer associated genes revealed by modern univariate and multivariate association tests
Q92894369GSK3-CRMP2 signaling mediates axonal regeneration induced by Pten knockout
Q36723394GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway.
Q38272835Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Q28086828Growth control mechanisms in neuronal regeneration
Q57062032HSP90 is a chaperone for DLK and is required for axon injury signaling
Q38544635Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
Q40434695Independent control of aging and axon regeneration.
Q53370006Inhibitory Injury Signaling Represses Axon Regeneration After Dorsal Root Injury.
Q52581957Intrinsic mechanisms of neuronal axon regeneration.
Q91991985Lab review: Molecular dissection of the signal transduction pathways associated with PTEN deletion-induced optic nerve regeneration
Q58764096Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration
Q88324990MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse
Q36022340MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression
Q55444729Microfluidics of Small-Population Neurons Allows for a Precise Quantification of the Peripheral Axonal Growth State.
Q38782131Models of axon regeneration in Drosophila.
Q49848129Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice.
Q38943137Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons
Q55305045Network analysis of microRNAs, transcription factors, and target genes involved in axon regeneration.
Q30597608Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.
Q42414570PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias
Q83600783PKCγ promotes axonal remodeling in the cortico-spinal tract via GSK3β/β-catenin signaling after traumatic brain injury
Q49815600PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling.
Q90703886PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo
Q49830059Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration
Q37584867Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion.
Q43154342Role of GSK3 in peripheral nerve regeneration.
Q38204164Signaling regulations of neuronal regenerative ability
Q64916582Small-Molecule SB216763-Loaded Microspheres Repair Peripheral Nerve Injury in Small Gap Tubulization.
Q92822624Spatiotemporal regulation of GSK3β levels by miRNA-26a controls axon development in cortical neurons
Q44773089Sustained GSK3 activity markedly facilitates nerve regeneration.
Q57826410Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3β-dependent pathway
Q90616401Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc
Q26796283The Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarction
Q39000464The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms
Q43002035The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
Q91864359Time course analysis of sensory axon regeneration in vivo by directly tracing regenerating axons
Q92268756Zonisamide enhances neurite outgrowth from adult rat dorsal root ganglion neurons, but not proliferation or migration of Schwann cells
Q33778165[EXPRESS] MicroRNA-9 regulates mammalian axon regeneration in peripheral nerve injury
Q36827582mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
Q55313334miR-129 controls axonal regeneration via regulating insulin-like growth factor-1 in peripheral nerve injury.

Search more.