The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress

scientific article published on 20 July 2009

The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01934-08
P932PMC publication ID2738294
P698PubMed publication ID19620285
P5875ResearchGate publication ID26683967

P50authorKatsuhiko ShirahigeQ28320469
P2093author name stringMakiko Komata
Masashige Bando
Hiroyuki Araki
P2860cites workA DNA helicase activity is associated with an MCM4, -6, and -7 protein complexQ24313590
Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiaeQ24533200
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicaseQ24548452
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replicationQ24561565
DNA synthesis at individual replication forks requires the essential initiation factor Cdc45pQ24599663
Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpointQ24642626
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
Uninterrupted MCM2-7 function required for DNA replication fork progressionQ27929772
Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regressionQ27931722
Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Q27932462
Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.Q27934738
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forksQ27934889
Mrc1 transduces signals of DNA replication stress to activate Rad53.Q27935521
Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.Q27937246
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complexQ27938718
The Mcm2-7 complex has in vitro helicase activity.Q27939144
Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo.Q27939613
AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexesQ28131706
The DNA damage response: ten years afterQ28261230
Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiaeQ28345987
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpointQ29614219
The DNA replication checkpoint response stabilizes stalled replication forksQ29618306
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
Different requirements for the association of ATR-ATRIP and 9-1-1 to the stalled replication forksQ33245762
RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.Q33969321
Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint responseQ34099551
Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiaeQ34276876
A unified view of the DNA-damage checkpointQ34560932
The DNA damage response during DNA replicationQ34561760
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structuresQ34649104
Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.Q35966662
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaksQ36686012
Replication fork barriers: pausing for a break or stalling for time?Q36777307
Characterization of a novel CDC gene (ORC1) partly homologous to CDC6 of Saccharomyces cerevisiaeQ36826841
Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathwaysQ39576012
Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.Q39998656
A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activationQ40522020
Unwind and slow down: checkpoint activation by helicase and polymerase uncouplingQ41888313
A central role for DNA replication forks in checkpoint activation and responseQ44455872
DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process.Q45028087
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.Q46949073
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damageQ54162557
The efficiency and timing of initiation of replication of multiple replicons of Saccharomyces cerevisiae chromosome VIQ74276976
Regulation of DNA-replication origins during cell-cycle progressionQ77448213
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)5008-5019
P577publication date2009-07-20
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress
P478volume29

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cites work (P2860)
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Q63965576DDR Inc., one business, two associates
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Q39424541Forks on the Run: Can the Stalling of DNA Replication Promote Epigenetic Changes?
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Q59795072Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage
Q93371579Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function
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Q33675748The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast
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