Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice

scientific article published on March 2011

Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1012168462
P356DOI10.2478/S13380-011-0011-8
P932PMC publication ID3839672
P698PubMed publication ID24286008
P5875ResearchGate publication ID258959414

P50authorLap HoQ60418097
P2093author name stringJun Wang
Wei Zhao
Giulio Maria Pasinetti
Alice Cheng
Merina Varghese
Xianjuan Qian
Amna Chaudhry
P2860cites workCorrelative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic MiceQ22242267
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
A "mitochondrial cascade hypothesis" for sporadic Alzheimer's diseaseQ30433751
Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's diseaseQ30492766
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse modelQ34276376
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.Q34562025
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristaeQ36856671
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseQ37321251
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progressionQ40301497
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failureQ41494079
Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD.Q43684857
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brainQ45304576
Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondriaQ46975941
Electron transport chain defects in Alzheimer's disease brainQ48107929
Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic miceQ48200932
Neocortical metabolic abnormalities precede nonmemory cognitive defects in early Alzheimer's-type dementiaQ48305999
Positron emission tomography in Alzheimer's diseaseQ48328045
Brain Cytochrome Oxidase in Alzheimer's DiseaseQ48453334
Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's diseaseQ48852396
Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.Q49134222
Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenaseQ53196480
Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease.Q53211339
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.Q53341470
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectmitochondrionQ39572
P577publication date2011-03-01
P1433published inTranslational neuroscienceQ27723509
P1476titleMitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice
P478volume2

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cites work (P2860)
Q48762970Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease
Q34252037Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice
Q91883758Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease
Q41427586NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease
Q37078497No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease
Q36433222Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice
Q34808701The effect of SOD1 mutation on cellular bioenergetic profile and viability in response to oxidative stress and influence of mutation-type.

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