scholarly article | Q13442814 |
P819 | ADS bibcode | 2013PNAS..11019095K |
P356 | DOI | 10.1073/PNAS.1315860110 |
P932 | PMC publication ID | 3839782 |
P698 | PubMed publication ID | 24191058 |
P50 | author | Mercedes Monteleone | Q57371844 |
Sabine Ehrt | Q61189875 | ||
Dirk Schnappinger | Q88475126 | ||
Kyu Y Rhee | Q93195831 | ||
Clifton E Barry | Q51118358 | ||
P2093 | author name string | Helena I M Boshoff | |
Daniel J Wilson | |||
Courtney C Aldrich | |||
Ritu Sharma | |||
Jee-Hyun Kim | |||
Sumit Chakraborty | |||
Joshua B Wallach | |||
Kathryn M O'Brien | |||
German Rehren | |||
P2860 | cites work | High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism | Q21131409 |
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties | Q24674719 | ||
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor | Q24802513 | ||
Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase | Q27636152 | ||
Engineering controllable protein degradation. | Q51184362 | ||
Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo | Q28476622 | ||
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression | Q28477282 | ||
High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity | Q28480878 | ||
Global assessment of genomic regions required for growth in Mycobacterium tuberculosis | Q28484097 | ||
4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo | Q28484764 | ||
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli | Q28487010 | ||
Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene | Q28611177 | ||
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice | Q28909142 | ||
Drugs for bad bugs: confronting the challenges of antibacterial discovery | Q29547723 | ||
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates | Q29618010 | ||
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies | Q29619404 | ||
Persister cells | Q30018300 | ||
The Sir 2 family of protein deacetylases | Q33222287 | ||
Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis | Q33826465 | ||
Bacterial DNA ligases. | Q33953479 | ||
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection | Q34006776 | ||
NAD+ auxotrophy is bacteriocidal for the tubercle bacilli | Q34155799 | ||
ClpXP, an ATP-powered unfolding and protein-degradation machine | Q34198403 | ||
Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening | Q34355038 | ||
Depletion of antibiotic targets has widely varying effects on growth | Q34651942 | ||
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. | Q34723636 | ||
Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes | Q35180176 | ||
Confronting the scientific obstacles to global control of tuberculosis | Q36513366 | ||
A subsystems-based approach to the identification of drug targets in bacterial pathogens. | Q36695075 | ||
Microbial phenotypic heterogeneity and antibiotic tolerance. | Q36704124 | ||
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis | Q36954404 | ||
Improved tetracycline repressors for gene silencing in mycobacteria | Q37149754 | ||
The Influence of Adverse Conditions upon the Respiratory Metabolism and Growth of Human Tubercle Bacilli | Q37678699 | ||
Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies. | Q37860758 | ||
New tuberculosis drugs on the horizon | Q37912808 | ||
Salmonella persistence and transmission strategies | Q37964243 | ||
Engineered Tet repressors with recognition specificity for the tetO-4C5G operator variant | Q38297444 | ||
Single-chain Tet transregulators | Q39778017 | ||
Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach | Q41849520 | ||
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions | Q42152549 | ||
Functional comparison of the NAD binding cleft of ADP-ribosylating toxins | Q42629538 | ||
P433 | issue | 47 | |
P407 | language of work or name | English | Q1860 |
P1104 | number of pages | 6 | |
P304 | page(s) | 19095-19100 | |
P577 | publication date | 2013-11-04 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence | |
P478 | volume | 110 |
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Q38973157 | Assessing essentiality of transketolase in Mycobacterium tuberculosis using an inducible protein degradation system |
Q40793029 | Cloning, expression and characterization of histidine-tagged biotin synthase of Mycobacterium tuberculosis. |
Q40854279 | Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of NAD synthetase from methicillin-resistant Staphylococcus aureus |
Q53290093 | Construction of conditional knockdown mutants in mycobacteria. |
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Q52562988 | Targeting protein biotinylation enhances tuberculosis chemotherapy. |
Q49488769 | The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis. |
Q26795478 | The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis |
Q37203793 | Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3 |
Q89635890 | Tissue distribution of doxycycline in animal models of tuberculosis |
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Q28390218 | Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool |
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