Structure and function of von Willebrand factor: relationship to von Willebrand's disease

scientific article published on August 1991

Structure and function of von Willebrand factor: relationship to von Willebrand's disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S0025-6196(12)61204-X
P698PubMed publication ID1907344

P2093author name stringZ M Ruggeri
P2860cites workEvidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagenQ24292860
Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factorQ24295998
Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand diseaseQ24561673
Studies on the mechanism of ristocetin-induced platelet agglutination. Effects of structural modification of ristocetin and vancomycinQ24595238
New perspectives in cell adhesion: RGD and integrinsQ28280381
Amino acid sequence of human von Willebrand factorQ28630812
The molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domainQ28776603
Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequencesQ28776606
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the moleculeQ29616413
von Willebrand's variant (type II Buffalo). Thrombocytopenia after desmopressin but absence of in vitro hypersensitivity to ristocetinQ33404697
Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factorQ33444536
Properties of human asialo-factor VIII. A ristocetin-independent platelet-aggregating agentQ33481601
Pseudo-von Willebrand's disease. An intrinsic platelet defect with aggregation by unmodified human factor VIII/von Willebrand factor and enhanced adsorption of its high-molecular-weight multimersQ33481677
Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpuraQ33481821
Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of severe von Willebrand diseaseQ33567446
Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factorQ33749366
Platelets have more than one binding site for von Willebrand factorQ33821754
Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.Q33857871
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stressQ34182746
Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIaQ34260216
Prevention of occlusive coronary artery thrombosis by a murine monoclonal antibody to porcine von Willebrand factorQ34366855
Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE).Q34528381
Biosynthesis of von Willebrand protein by human megakaryocytesQ34554462
Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rateQ34564820
von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemiaQ34574601
Venom coagglutinin: an activator of platelet aggregation dependent on von Willebrand factorQ35991709
Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localizationQ36212119
Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (type IIC)Q36988093
An explanation for minor multimer species in endothelial cell-synthesized von Willebrand factorQ36994972
Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and plateletsQ37023086
Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's diseaseQ37046074
Investigation of a kindred with a new autosomal dominantly inherited variant type von Willebrand's disease (possible type IID).Q37192691
Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptorQ37470139
In vitro correction of the abnormal multimeric structure of von Willebrand factor in type IIa von Willebrand's diseaseQ37531782
von Willebrand factor biosynthesis and processingQ37711742
Nucleotide sequence of pre-pro-von Willebrand factor cDNA.Q40418506
Gene deletions correlate with the development of alloantibodies in von Willebrand diseaseQ40922128
Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reactionQ44468499
Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coliQ44699205
Type II H von Willebrand disease: new structural abnormality of plasma and platelet von Willebrand factor in a patient with prolonged bleeding time and borderline levels of ristocetin cofactor activityQ44880774
Binding of von Willebrand factor to glycoproteins Ib and IIb/IIIa complex: affinity is related to multimeric sizeQ45884940
Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen IIQ56459904
von Willebrand disease type IIC with different abnormalities of von Willebrand factor in the same sibshipQ68792876
Multimeric pattern discrepancy between platelet and plasma von Willebrand factor in type IIC von Willebrand diseaseQ68794895
Heterogeneity in type IIB von Willebrand disease: two unrelated cases with no family history and mild abnormalities of ristocetin-induced interaction between von Willebrand factor and plateletsQ68810483
A variant of type II von Willebrand disease with an abnormal triplet structure and discordant effects of protease inhibitors on plasma and platelet von Willebrand factor structureQ68816172
Investigation of a case of subtype IIC von Willebrand disease: characterization of the variability of this subtypeQ70291513
Von Willebrand factor multimer patterns in von Willebrand's diseaseQ70454272
Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's diseaseQ71498185
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)847-861
P577publication date1991-08-01
P1433published inMayo Clin ProcQ6538184
P1476titleStructure and function of von Willebrand factor: relationship to von Willebrand's disease
P478volume66

Reverse relations

cites work (P2860)
Q33968288A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13
Q45866539A monoclonal antibody (B724) to von Willebrand factor recognizing an epitope within the A1 disulphide loop (Cys509-Cys695) discriminates between type 2A and type 2B von Willebrand disease
Q40579954A new flow cytometric method for measurement of von Willebrand factor activity
Q47287083A novel type 2A (Group II) von Willebrand disease mutation (L1503Q) associated with loss of the highest molecular weight von Willebrand factor multimers
Q38380070ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women
Q45886373Appendix II: A revised classification of Von Willebrand disease*: For The Subcommittee on Von Willebrand Factor of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
Q34466077Evaluation of von Willebrand factor and von Willebrand factor propeptide in models of vascular endothelial cell activation, perturbation, and/or injury
Q36925330Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets
Q30811796Labelling of rat endothelial cells with antibodies to vWF, RECA-1, PECAM-1, ICAM-1, OX-43 and ZO-1.
Q40519731New variant of type II von Willebrand's disease with structural abnormality of plasma von Willebrand factor in a patient with very mild bleeding history
Q35010760Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma
Q41040556Proteolytic processing of von Willebrand factor subunit: heterogeneity in type-IIA von Willebrand disease
Q33740244Recombinant von Willebrand factor: potential therapeutic use.
Q38880592The clinical value of von Willebrand factor in colorectal carcinomas.
Q40817282The pathologist as a clinical consultant for hemostasis in the community hospital.
Q47766336Type III von Willebrand's disease in Dutch kooiker dogs

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