A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice

scientific article published on 24 August 2016

A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01141-16
P932PMC publication ID5068531
P698PubMed publication ID27558420

P2093author name stringDawei Xu
Hongjun Chen
Jianmei Yang
Xuesong Li
Hai Yu
Qinfang Liu
Wenjun Ma
Liping Yan
Zejun Li
Qiaoyang Teng
Guangyu Rong
Weixia Shen
P2860cites workPandemic Threat Posed by Avian Influenza A VirusesQ22299330
Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong?Q24684322
Genetics, receptor binding property, and transmissibility in mammals of naturally isolated H9N2 Avian Influenza virusesQ27322724
Evolution of H9N2 influenza viruses from domestic poultry in Mainland ChinaQ28262432
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferretsQ29619972
Human infection with a novel avian-origin influenza A (H7N9) virusQ29620049
Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment?Q30328654
Structural differences among hemagglutinins of influenza A virus subtypes are reflected in their antigenic architecture: analysis of H9 escape mutants.Q30336387
Continuing evolution of H9N2 influenza viruses in Southeastern China.Q30342420
Avian influenza viruses in Korean live poultry markets and their pathogenic potential.Q30350071
H9N2 influenza viruses isolated from poultry in Korean live bird markets continuously evolve and cause the severe clinical signs in layers.Q30356441
Characterization of avian H9N2 influenza viruses from United Arab Emirates 2000 to 2003Q30358664
Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study.Q30358802
Isolation and identification of swine influenza recombinant A/Swine/Shandong/1/2003(H9N2) virusQ45600146
Effective replication of human influenza viruses in mice lacking a major α2,6 sialyltransferaseQ56879902
Universal primer set for the full-length amplification of all influenza A virusesQ57202943
Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005.Q30358972
Antigenic and genetic characterization of H9N2 swine influenza viruses in China.Q30362177
The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005Q30363051
Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus.Q30370276
Replication and transmission of H9N2 influenza viruses in ferrets: evaluation of pandemic potential.Q30371348
Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.Q30374182
Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virusQ30376280
Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian hostQ30383968
Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008Q30392278
Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt.Q30403405
Phylogeography and evolutionary history of reassortant H9N2 viruses with potential human health implicationsQ30403938
Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to miceQ30408939
Phylogenetic and antigenic characterization of reassortant H9N2 avian influenza viruses isolated from wild waterfowl in the East Dongting Lake wetland in 2011-2012.Q33574326
The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restrictionQ33784062
H9N2 influenza viruses possessing H5N1-like internal genomes continue to circulate in poultry in southeastern ChinaQ33811243
Phylogenetic diversity and genotypical complexity of H9N2 influenza A viruses revealed by genomic sequence analysisQ33840903
Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse modelQ33987340
Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003.Q34143724
Glycomic analysis of human respiratory tract tissues and correlation with influenza virus infectionQ34629170
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western ChinaQ34651554
Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesisQ35192665
PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesQ36500007
Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and miceQ36607195
Mutational analysis of conserved amino acids in the influenza A virus nucleoproteinQ37157108
A novel genotype H9N2 influenza virus possessing human H5N1 internal genomes has been circulating in poultry in eastern China since 1998.Q37333722
Rapid emergence of a PB2-E627K substitution confers a virulent phenotype to an H9N2 avian influenza virus during adoption in miceQ41420081
Avian influenza H9N2 seroprevalence among swine farm residents in ChinaQ42234155
Evidence of avian-like H9N2 influenza A virus among dogs in Guangxi, ChinaQ42259670
Amino acid 226 in the hemagglutinin of H9N2 influenza viruses determines cell tropism and replication in human airway epithelial cellsQ42737927
Seroprevalence of avian influenza H9N2 among poultry workers in Shandong Province, ChinaQ43170842
Genetic evolution of the H9N2 avian influenza virus in Korean poultry farmsQ43171982
Avian influenza infection in birds: a challenge and opportunity for the poultry veterinarianQ43175096
Human infection with influenza H9N2.Q43209306
Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in AsiaQ43209344
H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificityQ43209491
Detection of expression of influenza virus receptors in tissues of BALB/c mice by histochemistryQ43700477
Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virusQ44452346
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectavian influenzaQ43987
P304page(s)9806-9825
P577publication date2016-08-24
P1433published inJournal of VirologyQ1251128
P1476titleA Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice
P478volume90

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cites work (P2860)
Q95836407A D200N hemagglutinin substitution contributes to antigenic changes and increased replication of avian H9N2 influenza virus
Q91714799A Global Perspective on H9N2 Avian Influenza Virus
Q90435114A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity
Q89831108A unique feature of swine ANP32A provides susceptibility to avian influenza virus infection in pigs
Q52624521Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice.
Q60922594Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential
Q102388769Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens
Q91813518Genetic Characteristics and Pathogenicity Analysis in Chickens and Mice of Three H9N2 Avian Influenza Viruses
Q43168053Genetic characterization of H9N2 avian influenza viruses isolated from poultry in Poland during 2013/2014.
Q64107279H9N2 Viruses Isolated From Mammals Replicated in Mice at Higher Levels Than Avian-Origin Viruses
Q47553700H9N2 influenza virus isolated from minks has enhanced virulence in mice.
Q92717896Inventory of molecular markers affecting biological characteristics of avian influenza A viruses
Q96813664Molecular characterization and pathogenesis of H9N2 avian influenza virus isolated from a racing pigeon
Q64131162Molecular characterization and receptor binding specificity of H9N2 avian influenza viruses based on poultry-related environmental surveillance in China between 2013 and 2016
Q40349808Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice.
Q92255895Poultry trading behaviours in Vietnamese live bird markets as risk factors for avian influenza infection in chickens
Q52609298T160A mutation-induced deglycosylation at site 158 in hemagglutinin is a critical determinant of the dual receptor binding properties of clade 2.3.4.4 H5NX subtype avian influenza viruses.
Q30398273The T160A hemagglutinin substitution affects not only receptor binding property but also transmissibility of H5N1 clade 2.3.4 avian influenza virus in guinea pigs
Q91800481The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015 - 2016
Q58594646The molecular basis of antigenic variation among A(H9N2) avian influenza viruses
Q47281442The structural variability of the influenza A hemagglutinin receptor-binding site
Q30400181Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion

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