Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization

scientific article published on September 2008

Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.181.6.3984
P932PMC publication ID2744309
P698PubMed publication ID18768853
P5875ResearchGate publication ID23235614

P2093author name stringJoseph F Urban
William E Paul
Jinfang Zhu
Liying Guo
P2860cites workThe phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1Q24293229
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserineQ24322674
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growthQ24322716
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signalingQ24540545
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteinsQ24673877
X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2Q27635199
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesQ27861101
Transcriptional regulation by the phosphorylation-dependent factor CREBQ28210623
NFAT proteins: key regulators of T-cell development and functionQ28253919
Calcium signaling mechanisms in T lymphocytesQ32186061
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathwayQ33888844
In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production.Q34075330
Transcriptional mechanisms underlying lymphocyte tolerance.Q34135663
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinasesQ34398421
MAP kinases in the immune responseQ34542231
Protein kinase C(theta) in T cell activationQ34542294
Phosphorylation of c-jun mediated by MAP kinases.Q34947174
Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondiiQ35495758
Protein Phosphatases in PlantsQ35540282
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.Q35829153
Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cellsQ35920795
Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytesQ35931834
The T cell receptor: critical role of the membrane environment in receptor assembly and functionQ36072410
The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.Q36125128
The many paths to p38 mitogen-activated protein kinase activation in the immune systemQ36518938
Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 geneQ38295828
Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATcQ38317270
NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytesQ38328214
Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28Q38336999
Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in miceQ39243584
Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IVQ39675996
Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.Q39697358
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activationQ40099242
Calcium-dependent activation of interleukin-21 gene expression in T cellsQ40425368
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.Q41079307
JNK is involved in signal integration during costimulation of T lymphocytes.Q41461688
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.Q41850515
Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophilsQ43636843
Calcium-regulated expression of activin A in RBL-2H3 mast cellsQ44394224
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transductionQ44684470
Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociationQ44701428
Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegansQ47069479
Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses.Q50941847
The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells.Q51987576
Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells.Q52200239
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.Q54595193
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionQ62817899
Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 geneQ73406631
Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanismsQ77787560
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3984-3993
P577publication date2008-09-01
P1433published inJournal of ImmunologyQ3521441
P1476titleElevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization
P478volume181

Reverse relations

cites work (P2860)
Q34024993Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes
Q54385406Enhanced lymphocyte interferon (IFN)-γ responses in a PTEN mutation-negative Cowden disease kindred.
Q44901353Evaluation of calcineurin/NFAT inhibitor selectivity in primary human Th cells using bar-coding and phospho-flow cytometry
Q37617596Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells
Q28085747History of interleukin-4
Q53208095Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation.
Q54440726Knocking down Cav1 calcium channels implicated in Th2 cell activation prevents experimental asthma.
Q37622487Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
Q87091838Role of Ca/CaN/NFAT signaling in IL-4 expression by splenic lymphocytes exposed to phthalate (2-ethylhexyl) ester in spleen lymphocytes
Q91629567Shaping the diversity of Th2 cell responses in epithelial tissues and its potential for allergy treatment
Q37399731Signals for the execution of Th2 effector function
Q60044509Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
Q35023656The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection
Q37311417The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells
Q55204036Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes.
Q33996893Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.
Q36014394p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination.

Search more.