Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination.

scientific article published on May 2008

Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.1180-08.2008
P932PMC publication ID3844801
P698PubMed publication ID18480276
P5875ResearchGate publication ID5371797

P50authorPeter CarmelietQ2074300
Melissa M GresleQ59677030
Michele D BinderQ59677309
Helmut ButzkuevenQ38800130
Vilija JokubaitisQ41721863
Trevor KilpatrickQ42683104
P2093author name stringHolly S Cate
Anne L Prieto
Dennis Kemper
Tania Cipriani
P2860cites workGas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosisQ24337862
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Iba1 is an actin-cross-linking protein in macrophages/microgliaQ28212285
Relapsing and remitting multiple sclerosis: pathology of the newly forming lesionQ28253124
Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in miceQ28271366
Absence of macrophage-inflammatory protein-1alpha delays central nervous system demyelination in the presence of an intact blood-brain barrier.Q52543696
A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.Q54102022
TAM receptor function in the retinal pigment epitheliumQ56878898
Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repairQ58425790
Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte lossQ58425792
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survivalQ58425803
Multiple extracellular signals are required for long-term oligodendrocyte survivalQ72930271
Oligodendroglial-derived stress signals recruit microglia in vitroQ73514772
Nonactivated microglia promote oligodendrocyte precursor survival and maturation through the transcription factor NF-kappa BQ73663086
Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating diseaseQ81077809
Microglia-specific localisation of a novel calcium binding protein, Iba1Q28273977
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinasesQ28298018
Twist mediates suppression of inflammation by type I IFNs and AxlQ28509359
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 familyQ28585446
Tyro-3 family receptors are essential regulators of mammalian spermatogenesisQ28585555
Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissueQ29615225
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.Q31929744
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytesQ33895965
Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous systemQ33914948
Phagocytosis and clearance of apoptotic cells is mediated by MER.Q33946282
Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons.Q33966953
The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system.Q34122755
The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway.Q34199507
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesQ34319294
Identification of Gas6 as a growth factor for human Schwann cellsQ34375643
Cell death and control of cell survival in the oligodendrocyte lineageQ34460930
Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelinationQ34650995
Macrophage regulation by Tyro 3 family receptorsQ35031954
Deleterious role of IFNgamma in a toxic model of central nervous system demyelinationQ35088218
Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neuronsQ36439979
Growth of a rat neuroblastoma cell line in serum-free supplemented mediumQ37313160
Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitroQ40737625
An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous systemQ41183910
The protective role of nitric oxide in a neurotoxicant-induced demyelinating modelQ43829944
Effects of lipopolysaccharide on oligodendrocyte progenitor cells are mediated by astrocytes and microgliaQ44598095
Immunoexpression of Tyro 3 family receptors--Tyro 3, Axl, and Mer--and their ligand Gas6 in postnatal developing mouse testisQ46546846
Functional Genomic Analysis of Remyelination Reveals Importance of Inflammation in Oligodendrocyte RegenerationQ47415104
Quantifying the early stages of remyelination following cuprizone-induced demyelination.Q48214877
Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 miceQ48300700
Gas6 rescues cortical neurons from amyloid beta protein-induced apoptosisQ48409649
Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood-brain barrierQ48487727
TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelinationQ48744723
The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia.Q51113861
P4510describes a project that usesImageJQ1659584
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectcuprizoneQ27262585
oligodendrocyteQ916698
microgliaQ1622829
P304page(s)5195-5206
P577publication date2008-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleGas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
P478volume28