Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic

scientific article published on December 15, 1992

Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1992PNAS...8912180K
P356DOI10.1073/PNAS.89.24.12180
P953full work available at URLhttps://europepmc.org/articles/PMC50722
https://europepmc.org/articles/PMC50722?pdf=render
P932PMC publication ID50722
P698PubMed publication ID1334560
P5875ResearchGate publication ID21820270

P2093author name stringD. R. Lowy
J. T. Schiller
N. Cheng
F. Booy
R. Kirnbauer
P2860cites workStructures of bovine and human papillomaviruses. Analysis by cryoelectron microscopy and three-dimensional image reconstructionQ30447715
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Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virionsQ37519329
Proteins present in bovine papillomavirus particlesQ40141182
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Production of human papillomavirus and modulation of the infectious program in epithelial raft cultures. OFFQ42818510
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Synthesis and assembly of hepatitis B virus surface antigen particles in yeastQ45793098
A quantitative in vitro focus assay for bovine papilloma virusQ45803536
Yeast-recombinant hepatitis B vaccine. Efficacy with hepatitis B immune globulin in prevention of perinatal hepatitis B virus transmissionQ45839365
Structure of simian virus 40 at 3.8-A resolutionQ45861692
Human papillomavirus type 16 DNA sequenceQ48376786
Monoclonal antibodies to genus- and type-specific papillomavirus structural antigens.Q52489682
Viruses in human cancersQ56486194
Effective vaccination against papilloma development by immunization with L1 or L2 structural protein of cottontail rabbit papillomavirusQ56797784
The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopesQ67686616
Comparison of neutralization of BPV-1 infection of C127 cells and bovine fetal skin xenograftsQ67698418
Immunization against bovine papillomavirus infectionQ70142089
A COMPARATIVE STUDY OF POLYOMA AND PAPILLOMA VIRUSESQ76580918
Further observations on immunity to bovine cutaneous papillomatosisQ78850575
Baculovirus vectors for multiple gene expression and for occluded virus productionQ95816342
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
self-assemblyQ910150
capsid proteinsQ24779924
P304page(s)12180-12184
P577publication date1992-12-01
1992-12-15
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePapillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic
P478volume89

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Q28081156Long-term efficacy and safety of human papillomavirus vaccination
Q33834872Maturation of papillomavirus capsids
Q30155145Max Bergmann lecture protein epitope mimetics in the age of structural vaccinology
Q33856453Measurement of neutralizing serum antibodies of patients vaccinated with human papillomavirus L1 or L2-based immunogens using furin-cleaved HPV Pseudovirions
Q92871138Mesoscale model of the assembly and cross-linking of HPV virus-like particles
Q42182822Molecular analysis of human papillomavirus virus-like particle activated Langerhans cells in vitro
Q26771656Molecular pharming - VLPs made in plants
Q43636904Monoclonal antibodies recognizing cross-neutralization epitopes in human papillomavirus 16 minor capsid protein L2.
Q37135012Morbidity and mortality of vulvar and vaginal cancers: Impact of 2-, 4-, and 9-valent HPV vaccines
Q33823755Mucosal but not parenteral immunization with purified human papillomavirus type 16 virus-like particles induces neutralizing titers of antibodies throughout the estrous cycle of mice
Q34075698Mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of DNA vaccination
Q38830323Multivalent and Multipathogen Viral Vector Vaccines
Q34639978Multivalent human papillomavirus l1 DNA vaccination utilizing electroporation
Q34000082Murine polyomavirus virus-like particles carrying full-length human PSA protect BALB/c mice from outgrowth of a PSA expressing tumor
Q33822614Nasal immunization of mice with human papillomavirus type 16 (HPV-16) virus-like particles or with the HPV-16 L1 gene elicits specific cytotoxic T lymphocytes in vaginal draining lymph nodes
Q33784891Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions
Q41926483Naturally Occurring Single Amino Acid Substitution in the L1 Major Capsid Protein of Human Papillomavirus Type 16: Alteration of Susceptibility to Antibody-Mediated Neutralization
Q43605407Neutralization of HPV16, 18, 31, and 58 pseudovirions with antisera induced by immunizing rabbits with synthetic peptides representing segments of the HPV16 minor capsid protein L2 surface region
Q36637389Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteins
Q35947703Neutralization of human papillomavirus with monoclonal antibodies reveals different mechanisms of inhibition
Q36933073Neutralizing antibodies against human papillomavirus types 16, 18, 31, 52, and 58 in serum samples from women in Japan with low-grade cervical intraepithelial neoplasia
Q37137430New Approaches to Immunotherapy for HPV Associated Cancers
Q34477924New viral vaccines.
Q33433442Nobel price for vaccination against cervical cancer: current data and guidelines
Q35642774Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27.
Q41633745Novel structural features of bovine papillomavirus capsid revealed by a three-dimensional reconstruction to 9 A resolution
Q24294995Nuclear import strategies of high risk HPV16 L1 major capsid protein
Q40468775Nuclear localization but not PML protein is required for incorporation of the papillomavirus minor capsid protein L2 into virus-like particles.
Q26853380Nuns, warts, viruses, and cancer
Q54263650Opportunities and challenges for human papillomavirus vaccination in cancer.
Q33943463Optimization of a human papillomavirus-specific enzyme-linked immunosorbent assay.
Q53383624Oral administration of HPV-16 L2 displayed on Lactobacillus casei induces systematic and mucosal cross-neutralizing effects in Balb/c mice.
Q43965189Oral vaccination of mice with human papillomavirus virus-like particles induces systemic virus-neutralizing antibodies.
Q33571959Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
Q26801497Papillomavirus Infectious Pathways: A Comparison of Systems
Q35845291Papillomavirus L1 capsids agglutinate mouse erythrocytes through a proteinaceous receptor
Q33785870Papillomavirus assembly requires trimerization of the major capsid protein by disulfides between two highly conserved cysteines
Q38795804Papillomavirus assembly: An overview and perspectives
Q35831992Papillomavirus capsid binding and uptake by cells from different tissues and species.
Q33788885Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer
Q33814170Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability
Q34699403Papillomavirus capsid proteins mutually impact structure
Q34178325Papillomavirus infection requires gamma secretase
Q33614425Papillomavirus prophylactic vaccines: established successes, new approaches
Q33780651Papillomavirus pseudovirions packaged with the L2 gene induce cross-neutralizing antibodies
Q33847557Papillomavirus pseudovirus: a novel vaccine to induce mucosal and systemic cytotoxic T-lymphocyte responses
Q35193613Papillomavirus vaccines in clinical trials
Q45481228Papillomavirus virus-like particles induce cytokines characteristic of innate immune responses in plasmacytoid dendritic cells
Q34451862Papillomavirus-like particle based vaccines: cervical cancer and beyond
Q37219748Papillomavirus-like particles are an effective platform for amyloid-beta immunization in rabbits and transgenic mice
Q37568227Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88.
Q37208883Papillomaviruses--to vaccination and beyond
Q44182045Papillomaviruses: prophylactic vaccine prospects
Q40762506Parenteral and oral immunization with a plasmid DNA expressing the human papillomavirus 16-L1 gene induces systemic and mucosal antibodies and cytotoxic T lymphocyte responses
Q33905022Persistent antibodies to HPV virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated HPV.
Q34011494Perspectives for preventive and therapeutic HPV vaccines
Q37658876Perspectives for the development of human papillomavirus vaccines and immunotherapy
Q80206650Perspectives of contemporary papillomavirus research
Q36827128Phylogenetic considerations in designing a broadly protective multimeric L2 vaccine
Q38301730Physical interaction of human papillomavirus virus-like particles with immune cells
Q93002085Polymeric micro- and nanoparticles for immune modulation
Q43514345Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy.
Q33848323Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection
Q35228978Prevalence of antibodies to human papillomavirus (HPV) type 16 virus-like particles in relation to cervical HPV infection among college women
Q82343754Prevention is better than cure
Q34762053Prevention of cancer by prophylactic human papillomavirus vaccines
Q34708041Prevention of cancer through immunization: Prospects and challenges for the 21st century.
Q35620080Prevention of cervical cancer through papillomavirus vaccination
Q34272029Prevention of cervical cancer with vaccines
Q37021701Prevention, diagnosis, and treatment of cervical cancer
Q35037363Primary prevention of uterine cervix cancer: focus on vaccine history and current strategy
Q37912228Primary prophylactic human papillomavirus vaccination programs: future perspective on global impact
Q38887093Production and evaluation of virus-like particles displaying immunogenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV)
Q28611356Production of Furin-Cleaved Papillomavirus Pseudovirions and Their Use for In Vitro Neutralization Assays of L1- or L2-Specific Antibodies
Q36555514Production of Human papillomavirus pseudovirions in plants and their use in pseudovirion-based neutralisation assays in mammalian cells
Q40730375Production of Influenza Virus HA1 Harboring Native-Like Epitopes by Pichia pastoris
Q40047040Production of highly immunogenic virus-like particles of bovine papillomavirus type 6 in silkworm pupae
Q37014047Progress and prospects for L2-based human papillomavirus vaccines
Q35919119Progress in the development of a cervical cancer vaccine.
Q35984558Prophylactic HPV vaccines
Q36610447Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer
Q24545449Prophylactic human papillomavirus vaccines
Q33759930Prospects for prevention of HPV-driven oropharynx cancer
Q36545925Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2.
Q89969392Protection of outbred mice against a vaginal challenge by a Chlamydia trachomatis serovar E recombinant major outer membrane protein vaccine is dependent on phosphate substitution in the adjuvant
Q36314993Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2.
Q34347179Protective immunity to rabbit oral and cutaneous papillomaviruses by immunization with short peptides of L2, the minor capsid protein
Q35151690Proteomic characterization of influenza H5N1 virus-like particles and their protective immunogenicity.
Q90079811Public-private knowledge transfer and access to medicines: a systematic review and qualitative study of perceptions and roles of scientists involved in HPV vaccine research
Q80136333Quadrivalent human papillomavirus recombinant vaccine
Q40610561Quantitative and epitope-specific antigenicity analysis of the human papillomavirus 6 capsid protein in aqueous solution or when adsorbed on particulate adjuvants
Q39577044Quantitative disassembly and reassembly of human papillomavirus type 11 viruslike particles in vitro.
Q38819439Recent advancements in combination subunit vaccine development
Q34074998Recent advances in diagnosis and therapy of human papillomaviruses
Q36647920Recent advances in human papillomavirus vaccines
Q38075857Recent advances in molecular medicine techniques for the diagnosis, prevention, and control of infectious diseases
Q35842528Recent developments in human papillomavirus vaccines
Q38370782Recent progress in vaccination against human papillomavirus-mediated cervical cancer
Q36366466Recombinant measles virus-HPV vaccine candidates for prevention of cervical carcinoma
Q30412076Recombinant protein vaccines produced in insect cells
Q37488845Recombinant vaccines for the prevention of human papillomavirus infection and cervical cancer
Q34244580Reducing HPV-associated cancer globally.
Q39890236Refining HPV 16 L1 purification from E. coli: reducing endotoxin contaminations and their impact on immunogenicity
Q35866498Replication and assembly of human papillomaviruses
Q35150925Replication and partitioning of papillomavirus genomes
Q45753794Reversed-phase high-performance liquid chromatography of virus-like particles
Q36797004Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins.
Q37860337Role of AS04 in human papillomavirus vaccine: mode of action and clinical profile
Q33740579Roles for human papillomavirus type 16 l1 cysteine residues 161, 229, and 379 in genome encapsidation and capsid stability
Q54216752Roles of Fc domain and exudation in L2 antibody-mediated protection against human papillomavirus.
Q40936277Roots and perspectives of contemporary papillomavirus research
Q56959423Route of administration of chimeric BPV1 VLP determines the character of the induced immune responses
Q34360259Saccharomyces cerevisiae is permissive for replication of bovine papillomavirus type 1.
Q37612161Safety and immunogenicity of BPV-1 L1 virus-like particles in a dose-escalation vaccination trial in horses
Q36313476Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccine against cervical cancer and typhoid fever
Q42245288Searching for the initiating site of the major capsid protein to generate virus-like particles for a novel laboratory mouse papillomavirus
Q35541886Second-generation prophylactic HPV vaccines: successes and challenges
Q56959564Section Review: Biologicals & Immunologicals: Human papillomavirus infection, genital warts and cervical cancer: prospects for prophylactic and therapeutic vaccines
Q26767097Self-assembling protein nanoparticles in the design of vaccines
Q35228223Self-assembly of in vitro-translated human papillomavirus type 16 L1 capsid protein into virus-like particles and antigenic reactivity of the protein.
Q38950378Self-assembly of nanoparticles into biomimetic capsid-like nanoshells.
Q37226380Serological relationship between cutaneous human papillomavirus types 5, 8 and 92
Q38874078Short communication: limited induction of IL-10 in PBMCs from HIV-infected subjects treated with HIV-VLPs
Q34579346Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay
Q64374754Small size, big impact: how studies of small DNA tumour viruses revolutionized biology
Q36373404Sound efficacy of prophylactic HPV vaccination: Basics and implications
Q40396582Strategies for mapping and imitating viral B-cell epitopes
Q26777382Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens
Q100519112Structural characterization of a neutralizing mAb H16.001, a potent candidate for a common potency assay for various HPV16 VLPs
Q41605239Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization
Q35291103Structural studies on antibody-virus complexes
Q27625236Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16
Q41859327Structure-based engineering of papillomavirus major capsid l1: controlling particle assembly
Q42047559Structure-dependent efficacy of infectious bursal disease virus (IBDV) recombinant vaccines.
Q34071813Study of infectious virus production from HPV18/16 capsid chimeras
Q91688100Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and Immunogenicity
Q33812653Subviral particle as vaccine and vaccine platform
Q56355933Successful Vaccines
Q34408919Suppression of Langerhans cell activation is conserved amongst human papillomavirus α and β genotypes, but not a µ genotype
Q42245186Surface display of the HPV L1 capsid protein by the autotransporter Shigella IcsA.
Q33707499Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas
Q34357038Systemic, mucosal, and heterotypic immune induction in mice inoculated with Venezuelan equine encephalitis replicons expressing Norwalk virus-like particles
Q26824925Targeted Therapy in Oropharyngeal Squamous Cell Carcinoma: The Implications of HPV for Therapy
Q101559283Targeted next generation sequencing panel for HPV genotyping in cervical cancer
Q37033232Th2 polarization in peripheral blood mononuclear cells from human immunodeficiency virus (HIV)-infected subjects, as activated by HIV virus-like particles
Q27709061The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction
Q38959835The Density Code for the Development of a Vaccine?
Q42828087The L1 major capsid protein of HPV16 differentially modulates APC trafficking according to the vaccination or natural infection context
Q34181827The L1 major capsid protein of human papillomavirus type 11 interacts with Kap beta2 and Kap beta3 nuclear import receptors
Q33852592The L1 major capsid protein of human papillomavirus type 11 recombinant virus-like particles interacts with heparin and cell-surface glycosaminoglycans on human keratinocytes
Q33673620The L1 major capsid protein of human papillomavirus type 16 variants affects yield of virus-like particles produced in an insect cell expression system
Q21134079The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection
Q36281141The U4 Antibody Epitope on Human Papillomavirus 16 Identified by Cryo-electron Microscopy
Q38603912The application of virus-like particles as vaccines and biological vehicles
Q50851962The beginning of the end: vaccine prevention of HPV-driven cancers.
Q28302676The current status of therapeutic HPV vaccine
Q26861667The cytoskeleton in papillomavirus infection
Q45197725The development of vaccines: how the past led to the future
Q36827213The evolving field of human papillomavirus receptor research: a review of binding and entry.
Q39442569The feminization of HPV: How science, politics, economics and gender norms shaped U.S. HPV vaccine implementation
Q36679858The hallmarks of premalignant conditions: a molecular basis for cancer prevention
Q24610004The history of tumor virology
Q33848178The immunology of animal papillomaviruses
Q24309388The l2 minor capsid protein of human papillomavirus type 16 interacts with a network of nuclear import receptors
Q33781905The papillomavirus minor capsid protein, L2, induces localization of the major capsid protein, L1, and the viral transcription/replication protein, E2, to PML oncogenic domains
Q37683446The positively charged termini of L2 minor capsid protein required for bovine papillomavirus infection function separately in nuclear import and DNA binding
Q37822798The prevention of cervical cancer in Africa
Q33936363The role of vaccines in the control of STDs: HPV vaccines.
Q35541210The use of hybrid virus-like particles to enhance the immunogenicity of a broadly protective HPV vaccine
Q47255618Therapeutic vaccines for high-risk HPV-associated diseases.
Q36622630Three-dimensional structure of vaccinia virus-produced human papillomavirus type 1 capsids
Q24646183Tissue-spanning redox gradient-dependent assembly of native human papillomavirus type 16 virions
Q28730718Toolbox for non-intrusive structural and functional analysis of recombinant VLP based vaccines: a case study with hepatitis B vaccine
Q34353473Trachea, lung, and tracheobronchial lymph nodes are the major sites where antigen-presenting cells are detected after nasal vaccination of mice with human papillomavirus type 16 virus-like particles.
Q43711805Trivalent Human Papillomavirus (HPV) VLP vaccine covering HPV type 58 can elicit high level of humoral immunity but also induce immune interference among component types.
Q39875296Two amino acid residues confer type specificity to a neutralizing, conformationally dependent epitope on human papillomavirus type 11.
Q38041983Understanding and learning from the success of prophylactic human papillomavirus vaccines.
Q34351909Use of the baculovirus expression system for the generation of virus-like particles
Q38152475VLPs and particle strategies for cancer vaccines
Q28280059VLPs displaying a single L2 epitope induce broadly cross-neutralizing antibodies against human papillomavirus
Q38971587Vaccination Expectations in HNSCC.
Q36066161Vaccination strategies for the prevention of cervical cancer
Q34054427Vaccination with multimeric L2 fusion protein and L1 VLP or capsomeres to broaden protection against HPV infection
Q40168614Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.
Q40399200Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus
Q38087785Vaccine design: emerging concepts and renewed optimism
Q59350469Vaccine synergy with virus-like particle and immune complex platforms for delivery of human papillomavirus L2 antigen
Q35925621Vaccines against cervical cancer
Q37614961Vaccines and microbicides preventing HIV-1, HSV-2, and HPV mucosal transmission
Q36601830Vaccines for viral and parasitic diseases produced with baculovirus vectors
Q37737321Vaccines to prevent infections by oncoviruses
Q35290961Viral assembly using heterologous expression systems and cell extracts
Q37792984Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design
Q38554795Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology
Q92257210Virus-like Particle-Based L2 Vaccines against HPVs: Where Are We Today?
Q37608311Virus-like particle vaccines and adjuvants: the HPV paradigm
Q44084905Virus-like particles and capsomeres are potent vaccines against cutaneous alpha HPVs
Q38059059Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development
Q37666808Virus-like particles as a vaccine delivery system: myths and facts
Q35295832Virus-like particles as immunogens
Q37798008Virus-like particles in vaccine development.
Q24650772Virus-like particles production in green plants
Q30817169Virus-like particles: a new family of delivery systems
Q36837144Virus-like particles: flexible platforms for vaccine development
Q36602264Virus-like particles: passport to immune recognition
Q33670688Whole-Genome Analysis of Human Papillomavirus Types 16, 18, and 58 Isolated from Cervical Precancer and Cancer Samples in Chinese Women
Q82970082[Anal HPV infections]
Q84796169[HPV infections of the oral and genital mucosa. Possibilities for primary prevention]
Q80275938[HPV vaccines. Prophylactic vaccines from virus-like particles]
Q80319619[Humoral and cellular immune response in HPV vaccination]
Q79939143[Prophylactic vaccination against human papillomavirus]

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