Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury

scientific article published on July 2009

Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1227/01.NEU.0000346272.76537.DC
P932PMC publication ID2749520
P698PubMed publication ID19574840

P50authorMichael ChoppQ71037672
P2093author name stringBo Li
Asim Mahmood
Changsheng Qu
Ye Xiong
Hongtao Wu
Dunyue Lu
P2860cites workLovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophagesQ24561388
Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice culturesQ33216380
The glial scar and central nervous system repairQ33731601
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Statins and elevated liver tests: what's the fuss?Q37215578
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Temporal profile of release of interleukin-1beta in neurotraumaQ41921844
Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injuryQ42384723
Down-regulation of occludin expression in astrocytes by tumour necrosis factor (TNF) is mediated via TNF type-1 receptor and nuclear factor-kappaB activationQ42506605
Interleukin-6 promotes post-traumatic healing in the central nervous systemQ43558969
Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonistQ44133445
Statins induce angiogenesis, neurogenesis, and synaptogenesis after strokeQ44463534
Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, anQ44493582
Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injuryQ44778744
Neuroinflammatory responses after experimental diffuse traumatic brain injuryQ44933494
Simvastatin modulates TNFalpha-induced adhesion molecules expression in human endothelial cells.Q44963780
Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in ratsQ45191278
Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndromeQ46136981
Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatmentQ46946552
Lymphocyte infiltration in the injured brain: role of proinflammatory cytokinesQ47876796
Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury.Q48115190
Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in ratsQ48721941
Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidantsQ71644393
Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokinesQ73500487
Interleukin-6 and nerve growth factor upregulation correlates with improved outcome in children with severe traumatic brain injuryQ80914178
Statins and strokeQ81623503
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
astrocyteQ502961
simvastatinQ670131
microgliaQ1622829
traumatic brain injuryQ1995526
P304page(s)179-85; discussion 185-6
P577publication date2009-07-01
P1433published inNeurosurgeryQ7002693
P1476titleSimvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury
P478volume65

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