The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys

scientific article published on 10 June 2009

The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00213-009-1581-9
P932PMC publication ID2753862
P698PubMed publication ID19513698
P5875ResearchGate publication ID26280023

P50authorAmy Hauck NewmanQ76095333
P2093author name stringCindy Achat-Mendes
Donna M Platt
Roger D Spealman
P2860cites workEffects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and disQ48624409
Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeysQ48702113
Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalitiesQ48720196
Autoradiographic localisation of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907.Q48848853
Dopamine D3 receptor agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys.Q51563929
Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypesQ51707373
Intravenous self-administration techniques in monkeys.Q51958972
Intrinsic activity: partial agonists and partial antagonistsQ72695769
The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotionQ80098245
The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in ratsQ80605684
D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victimsQ22010414
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonistQ28141108
Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptorQ28305618
Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptorsQ28584977
High-fat diet induced adiposity in mice with targeted disruption of the dopamine-3 receptor geneQ28594901
Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonistsQ31409124
Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434.Q33907064
The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administeredQ33939745
Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeysQ33955144
Agonist efficacy, drug dependence, and medications development: preclinical evaluation of opioid, dopaminergic, and GABAA-ergic ligands.Q34188108
Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in ratsQ34222033
Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands.Q34297794
Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonistsQ34374970
Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposureQ34390138
Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptorsQ34414507
Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's diseaseQ34429102
Behavioral effects of cocaine and dopaminergic strategies for preclinical medication developmentQ34954205
Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbensQ35682043
Localization of dopamine D3 receptors to mesolimbic and D2 receptors to mesostriatal regions of human forebrainQ35904983
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agentsQ36139232
Is dopamine a physiologically relevant mediator of feeding behavior?Q36866383
Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in ratsQ37052512
The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesityQ37189418
Selective antagonism at dopamine D3 receptors as a target for drug addiction pharmacotherapy: a review of preclinical evidenceQ37363975
Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agentsQ40098776
Dopamine receptor agonists, partial agonists and psychostimulant addictionQ40562347
The D3 dopamine receptor: neurobiology and potential clinical relevance.Q41602038
Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.Q42557887
Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injectionsQ44273768
Altered feeding responses in mice with targeted disruption of the dopamine-3 receptor geneQ44348441
Cocaine-Seeking Behavior in Response to Drug-Associated Stimuli in Rats: Involvement of D3 and D2 Dopamine ReceptorsQ44407095
N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonistsQ44472688
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptorsQ44557226
Dopamine D3 receptor ligands block nicotine-induced conditioned place preferences through a mechanism that does not involve discriminative-stimulus or antidepressant-like effectsQ45161642
S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent. II. A neurochemical, electrophysiologicQ46462505
Modulation of cocaine self-administration in the rat through D-3 dopamine receptorsQ48266278
Effects of RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-butyl}-4-bromo-benzamide], an orally active, selective dopamine D(3) receptor partial agonist in animal models of cocaine abuseQ48337319
Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine cravingQ48421523
P433issue1
P921main subjectdopamineQ170304
P1104number of pages12
P304page(s)73-84
P577publication date2009-06-10
P1433published inPsychopharmacologyQ1422802
P1476titleThe dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys
P478volume206

Reverse relations

cites work (P2860)
Q28828620Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design
Q28275963Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse
Q36655271Cocaine self-administration in dopamine D₃ receptor knockout mice
Q33697312Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development.
Q24598398Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys
Q45058435Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
Q36581531Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm
Q36540036Effects of chronic buspirone treatment on cocaine self-administration
Q33944031Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys
Q35892818Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis
Q34762698Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys
Q37331530Medication discovery for addiction: translating the dopamine D3 receptor hypothesis
Q33636631New small molecules for the treatment of Parkinson's disease
Q37252065Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55
Q34524556Targeting the dopamine D3 receptor: an overview of drug design strategies
Q33992366The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access
Q24628933The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats