Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus

scientific article published on 09 September 2015

Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2015.08.034
P932PMC publication ID5089067
P698PubMed publication ID26365182
P5875ResearchGate publication ID281780259

P2093author name stringDavid B Roth
Martina Mijušković
Olga Shestova
Vered Gigi
Yi-Fan Chou
Cory R Lindsay
Susanna M Lewis
P2860cites workIdentification and utilization of arbitrary correlations in models of recombination signal sequencesQ24803178
Janus kinase deregulation in leukemia and lymphomaQ26991810
WebLogo: A Sequence Logo GeneratorQ27860646
RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'.Q33698668
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.Q33889784
An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.Q34042879
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Q34541666
Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesisQ34760276
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.Q34999834
The RAG2 C terminus suppresses genomic instability and lymphomagenesisQ35216006
Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancyQ35881724
A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencingQ36353713
Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failuresQ36517758
Cryptic signals and the fidelity of V(D)J joiningQ36568596
Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to diseaseQ38024988
The molecular basis of T cell acute lymphoblastic leukemiaQ38047834
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemiaQ38367298
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemiaQ39999145
Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas.Q40479977
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cellsQ45375299
An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendantsQ47936939
Isolation of an excision product of T-cell receptor alpha-chain gene rearrangementsQ48344445
Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays.Q50725987
Mus81-dependent double-strand DNA breaks at in vivo-generated cruciform structures in S. cerevisiae.Q51866610
Recombination activating genes (RAG) in lymphoma development.Q53346384
Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia.Q54408212
PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination eventsQ63865765
P433issue11
P304page(s)1842-1852
P577publication date2015-09-09
P1433published inCell ReportsQ5058165
P1476titleOff-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus
P478volume12