Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors

scientific article published on 22 September 2009

Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..10617158L
P356DOI10.1073/PNAS.0909520106
P932PMC publication ID2761323
P698PubMed publication ID19805176
P5875ResearchGate publication ID26871354

P2093author name stringSihong Song
Yuanqing Lu
P2860cites workSelf-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesisQ28213353
Adeno-associated virus serotypes: vector toolkit for human gene therapyQ33249130
Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibersQ33782809
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.Q34168942
Correction of the biochemical and functional deficits in fabry mice following AAV8-mediated hepatic expression of alpha-galactosidase A.Q34595095
Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transferQ34985105
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6Q35024289
Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cellsQ35186003
Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.Q36438711
AAV as an immunogenQ36990100
Major subsets of human dendritic cells are efficiently transduced by self-complementary adeno-associated virus vectors 1 and 2.Q40168483
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transferQ41920883
Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapyQ41999615
Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapyQ43801966
Ex vivo transduced liver progenitor cells as a platform for gene therapy in miceQ44147819
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD miceQ44719693
Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteinsQ45384856
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsidQ45414481
Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vectorQ45419136
Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene.Q45421368
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heartQ45507049
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunityQ45698037
Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectorsQ45735547
Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogsQ45856596
AAV8-mediated expression of glucocerebrosidase ameliorates the storage pathology in the visceral organs of a mouse model of Gaucher disease.Q45856667
Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic miceQ45859046
Immune responses to AAV capsid: are mice not humans after all?Q45866729
Erythropoietin gene therapy leads to autoimmune anemia in macaquesQ45871284
Surface alpha 2-3- and alpha 2-6-sialylation of human monocytes and derived dendritic cells and its influence on endocytosisQ46850314
Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cellsQ72357662
Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cellsQ72698982
AAV8-mediated hepatic expression of acid sphingomyelinase corrects the metabolic defect in the visceral organs of a mouse model of Niemann-Pick diseaseQ81058015
P433issue40
P407language of work or nameEnglishQ1860
P304page(s)17158-17162
P577publication date2009-09-22
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDistinct immune responses to transgene products from rAAV1 and rAAV8 vectors
P478volume106

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cites work (P2860)
Q36757066ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice
Q34810340Adipose tissue-derived mesenchymal stem cell-based liver gene delivery
Q90468943Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice
Q33671373Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats
Q39587262Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
Q93016705Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice
Q91296268Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies
Q39394803Complexity of immune responses to AAV transgene products - Example of factor IX.
Q38959186Continuous CD8⁺ T-cell priming by dendritic cell cross-presentation of persistent antigen following adeno-associated virus-mediated gene delivery
Q90434853Cross-Presentation of Skin-Targeted Recombinant Adeno-associated Virus 2/1 Transgene Induces Potent Resident Memory CD8+ T Cell Responses
Q38003108Detection of EPO gene doping in blood
Q36945745Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles
Q42175045Duchenne muscular dystrophy gene therapy in the canine model
Q35641673Duchenne muscular dystrophy gene therapy in the canine model.
Q37342834Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies
Q30490945Engineering antibody-like inhibitors to prevent and treat HIV-1 infection
Q27307010Impact of age at administration, lysosomal storage, and transgene regulatory elements on AAV2/8-mediated rat liver transduction
Q35451204Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer.
Q90275153In Situ Modification of Tissue Stem and Progenitor Cell Genomes
Q92301725Innate Immune Response Following AAV Administration
Q37939843Innate Immune Responses to AAV Vectors
Q40117829Intradermal Immunization with rAAV1 Vector Induces Robust Memory CD8(+) T Cell Responses Independently of Transgene Expression in DCs.
Q42996820Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease
Q92345037Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys
Q36940126Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver
Q45868167Longevity of rAAV vector and plasmid DNA in blood after intramuscular injection in nonhuman primates: implications for gene doping
Q26745822MicroRNA-regulated viral vectors for gene therapy
Q44861538Mir-142-3p target sequences reduce transgene-directed immunogenicity following intramuscular adeno-associated virus 1 vector-mediated gene delivery
Q35086714Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates
Q94547060Promise and Progress of an HIV-1 Cure by Adeno-Associated Virus Vector Delivery of Anti-HIV-1 Biologics
Q37621530Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies
Q92987777Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes
Q40084021Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler-Najjar Syndrome Type I.
Q36756695Serotype-specific Binding Properties and Nanoparticle Characteristics Contribute to the Immunogenicity of rAAV1 Vectors
Q98945200Synthetic immunomodulation with a CRISPR super-repressor in vivo
Q38908933Systemic delivery of adeno-associated viral vectors
Q35067592The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver
Q37393827The role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transfer

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