A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

scientific article published on 23 September 2009

A genomic screen identifies TYRO3 as a MITF regulator in melanoma. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..10617025Z
P356DOI10.1073/PNAS.0909292106
P932PMC publication ID2761329
P698PubMed publication ID19805117
P5875ResearchGate publication ID26871295

P50authorPeter G. SchultzQ899840
Costas A LyssiotisQ47451178
Haiyan TaoQ59297958
Heiko WurdakQ89782444
P2093author name stringJohn Walker
Yan Wang
Jie Li
Feng Yan
Xu Wu
Loren Miraglia
Shoutian Zhu
Anthony Orth
Anna Galkin
Buu P Tu
Fanxiang Sun
P2860cites workTransforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathwayQ22011040
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Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinaseQ24306999
Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3Q24321841
Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.Q24530573
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survivalQ24546291
Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3Q28138331
A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytesQ28204096
Acidification prevents endothelial cell apoptosis by Axl activationQ28205422
Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and AxlQ28277798
Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomasQ28278559
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinasesQ28298018
Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factorQ28509336
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cellsQ28509872
Tyro-3 family receptors are essential regulators of mammalian spermatogenesisQ28585555
Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinasesQ28587024
Large-scale analysis of the human and mouse transcriptomesQ29547360
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.Q33352015
Complex variant 15;17 translocations in acute promyelocytic leukemia. A case report and review of three-way translocationsQ33646603
The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophilsQ33775026
Immunobiology of the TAM receptorsQ33796991
Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.Q33970751
Final version of the American Joint Committee on Cancer staging system for cutaneous melanomaQ34086791
Metastatic melanoma: chemotherapyQ34156931
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesQ34319294
Radiation therapy following lymph node dissection in melanoma patients: treatment, outcome and complicationsQ34393597
BRAF somatic mutations in malignant melanoma and melanocytic naeviQ34506145
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.Q34568270
Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.Q34576544
Clonogenic assay of cells in vitro.Q34615431
TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancerQ34794927
The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and gliaQ35146531
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.Q35186010
Microphthalmia transcription factor. A sensitive and specific melanocyte marker for MelanomaDiagnosisQ35787813
Melanocytes and the microphthalmia transcription factor networkQ35965847
Growth arrest-specific gene 6 expression in human breast cancer.Q36510114
New insight into BRAF mutations in cancerQ36701579
Melanocyte biology and skin pigmentationQ36742011
Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor geneQ36800542
How to make a melanoma: what do we know of the primary clonal events?Q37114124
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cellsQ39954044
AXL is a potential target for therapeutic intervention in breast cancer progression.Q40002526
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.Q40014237
Mer receptor tyrosine kinase signaling: prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferationQ40740717
Gas 6 promotes Axl-mediated survival in pulmonary endothelial cellsQ40806568
The first laminin G-type domain in the SHBG-like region of protein S contains residues essential for activation of the receptor tyrosine kinase sky.Q40883711
Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters.Q40887733
Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation.Q41258260
Stimulation of sky receptor tyrosine kinase by the product of growth arrest-specific gene 6.Q41293269
Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinaseQ41358591
Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.Q46021434
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiformeQ46825520
Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase.Q46943661
Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclastsQ48001321
Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction.Q50948456
A receptor tyrosine kinase, Sky, and its ligand Gas 6 are expressed in gonads and support primordial germ cell growth or survival in culture.Q52198087
Synthesis and secretion of the anticoagulant protein S and coexpression of the Tyro3 receptor in human lung carcinoma cellsQ77953982
P433issue40
P407language of work or nameEnglishQ1860
P304page(s)17025-17030
P577publication date2009-09-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA genomic screen identifies TYRO3 as a MITF regulator in melanoma
P478volume106

Reverse relations

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