Cyclosporine modulation of multidrug resistance in combination with pravastatin, mitoxantrone and etoposide for adult patients with relapsed/refractory acute myeloid leukemia: a phase 1/2 study

scientific article published on 27 March 2013

Cyclosporine modulation of multidrug resistance in combination with pravastatin, mitoxantrone and etoposide for adult patients with relapsed/refractory acute myeloid leukemia: a phase 1/2 study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/10428194.2013.777836
P932PMC publication ID3863328
P698PubMed publication ID23432687
P5875ResearchGate publication ID235714157

P50authorMegan OthusQ75025967
Elihu EsteyQ96145785
P2093author name stringRoland B Walter
Kelda M Gardner
Tara L Chen
Lauren J Markle
P2860cites workMitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)Q33758413
Chemotherapy resistance in acute myeloid leukaemiaQ34252879
The role of drug efflux pumps in acute myeloid leukemia.Q34769834
Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: a novel paradigm for treatment assignmentQ35565648
Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 studyQ35750986
Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategiesQ35817464
Adaptive dose selection using efficacy-toxicity trade-offs: illustrations and practical considerationsQ36621967
Adaptive clinical trials in oncologyQ37953783
P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitorsQ40070493
A new statistical method for dose-finding based on efficacy and toxicity in early phase clinical trialsQ40781868
Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group studyQ43806484
Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responsesQ44265497
Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cellsQ44909361
Dose-finding based on efficacy-toxicity trade-offsQ45038149
Mitoxantrone, etoposide, and cytarabine plus cyclosporine for patients with relapsed or refractory acute myeloid leukemia: an Eastern Cooperative Oncology Group pilot study.Q54104948
P433issue11
P921main subjectleukemiaQ29496
acute myeloid leukemiaQ264118
cyclosporineQ367700
etoposideQ418817
multiple drug resistanceQ643839
P304page(s)2534-2536
P577publication date2013-03-27
P1433published inLeukemia & LymphomaQ6534493
P1476titleCyclosporine modulation of multidrug resistance in combination with pravastatin, mitoxantrone and etoposide for adult patients with relapsed/refractory acute myeloid leukemia: a phase 1/2 study
P478volume54

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cites work (P2860)
Q50639190An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials.
Q38654251Implementing the EffTox dose-finding design in the Matchpoint trial.
Q38973323Interactions Between Inflammatory Bowel Disease Drugs and Chemotherapy
Q58580490Phase 1/2 trial of cladribine, high-dose cytarabine, mitoxantrone, and G-CSF with dose-escalated mitoxantrone for relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms
Q43442213Reversing multidrug resistance (MDR1, ABCB1) in acute myeloid leukemia: back to the ABCs

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