Engineering actin-resistant human DNase I for treatment of cystic fibrosis

scientific article published on August 1996

Engineering actin-resistant human DNase I for treatment of cystic fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1996PNAS...93.8225U
P356DOI10.1073/PNAS.93.16.8225
P932PMC publication ID38651
P698PubMed publication ID8710851
P5875ResearchGate publication ID14491203

P2093author name stringSinicropi D
Dodge AH
Lazarus RA
Baker DL
Herzka A
Shak S
Toy KJ
Ulmer JS
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Recombinant human DNase I reduces the viscosity of cystic fibrosis sputumQ24556580
Atomic structure of the actin:DNase I complexQ27685392
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death)Q28582503
Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study GroupQ34290556
Actin is the naturally occurring inhibitor of deoxyribonuclease IQ35119169
Cystic fibrosis: molecular biology and therapeutic implicationsQ35319385
Structure and function of actinQ35351237
Genomic organisation and expression of mouse deoxyribonuclease I.Q36715989
Cystic fibrosis: a disease in electrolyte transport.Q37942450
X-ray structure of the DNase I-d(GGTATACC)2 complex at 2.3 A resolutionQ38326595
Depolymerization of F-actin by deoxyribonuclease IQ39779116
Actin.Q40927517
The inhibition of bovine and rat parotid deoxyribonuclease I by skeletal muscle actin. A biochemical and immunocytochemical studyQ42084869
Distinct sites on the G-actin molecule bind group-specific component and deoxyribonuclease I.Q42849753
The chemical synthesis of a gene coding for bovine pancreatic DNase I and its cloning and expression in Escherichia coliQ44256987
Colorimetric determination of DNase I activity with a DNA-methyl green substrateQ46114222
Compaction assay: a rapid and simple in vitro method to assess the responsiveness of a biopolymer matrix to enzymatic modification.Q52507133
Investigation of the actin-deoxyribonuclease I interaction using a pyrene-conjugated actin derivativeQ52715402
The Interaction of Bovine Pancreatic Deoxyribonuclease I and Skeletal Muscle ActinQ59663163
Localization of a vitamin-D-binding protein interaction site in the COOH-terminal sequence of actinQ67743021
A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosisQ68062090
Interactions among serum vitamin D binding protein, monomeric actin, profilin, and profilactinQ69936615
Efficacy and safety of short-term administration of aerosolised recombinant human DNase I in adults with stable stage cystic fibrosisQ72224833
DNase I increases the rate constant of depolymerization at the pointed (-) end of actin filamentsQ72371541
Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolinQ72778317
Efficacy and safety of short-term administration of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosisQ72796879
Deoxyribonuclease I in mammalian tissues. Specificity of inhibition by actinQ72883362
Liquefaction of viscous purulent exudates by deoxyribonucleaseQ75607550
STUDIES ON PULMONARY SECRETIONS. I. THE OVER-ALL CHEMICAL COMPOSITION OF PULMONARY SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS, BRONCHIECTASIS, AND LARYNGECTOMYQ76503773
Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasisQ79191483
Purification of muscle actinQ93859477
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectcystic fibrosisQ178194
P1104number of pages5
P304page(s)8225-8229
P577publication date1996-08-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEngineering actin-resistant human DNase I for treatment of cystic fibrosis
P478volume93

Reverse relations

cites work (P2860)
Q73746930A recombinant cytotoxic chimera based on mammalian deoxyribonuclease-I
Q48257985A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability
Q36951268Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth
Q28343588Amphibian DNases I are characterized by a C-terminal end with a unique, cysteine-rich stretch and by the insertion of a serine residue into the Ca2+-binding site
Q30586523Apoptosis-related functional features of the DNaseI-like family of nucleases
Q33518531Bi-directional SIFT predicts a subset of activating mutations
Q42930592Bioengineered lysozyme reduces bacterial burden and inflammation in a murine model of mucoid Pseudomonas aeruginosa lung infection
Q40927903Ca2+-dependent activity of human DNase I and its hyperactive variants
Q24308800Cloning and characterization of a novel human DNase
Q41014163Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages
Q42816497Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3).
Q27667276Crystal Structure of a Charge Engineered Human Lysozyme Having Enhanced Bactericidal Activity
Q30496665Enhanced antimicrobial activity of engineered human lysozyme
Q41616388Expression and characterization of a DNase I-Fc fusion enzyme
Q36469691Functional and structural characterization of chimeras of a bacterial genotoxin and human type I DNAse
Q33761257How cations can assist DNase I in DNA binding and hydrolysis
Q46500363Hyperactivity of human DNase I variants. Dependence on the number of positively charged residues and concentration, length, and environment of DNA.
Q54012100Improved activity of an actin-resistant DNase I variant on the cystic fibrosis airway secretions.
Q43685643Improved potency of hyperactive and actin-resistant human DNase I variants for treatment of cystic fibrosis and systemic lupus erythematosus
Q34493979LL-37 induces polymerization and bundling of actin and affects actin structure
Q28199068Lupus and desoxyribonuclease
Q28741382Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle
Q24643968Micro- and macrorheology of mucus
Q48359724Molecular, biochemical and immunological analyses of porcine pancreatic DNase I.
Q38317348Molecular, biochemical and immunological studies of hen pancreatic deoxyribonuclease I.
Q38338553Mutational analysis of human DNase I at the DNA binding interface: implications for DNA recognition, catalysis, and metal ion dependence
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Q77151788Pharmacodynamics of recombinant human DNase I in serum
Q42159685Rabbit DNase I: purification from urine, immunological and proteochemical characterization, nucleotide sequence, expression in tissues, relationships with other mammalian DNases I and phylogenetic analysis
Q40116758Resistance of the antibacterial agent ceragenin CSA-13 to inactivation by DNA or F-actin and its activity in cystic fibrosis sputum
Q36237958Role of magnesium in the failure of rhDNase therapy in patients with cystic fibrosis
Q40871295Surface-localized spermidine protects the Pseudomonas aeruginosa outer membrane from antibiotic treatment and oxidative stress
Q47576141Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells
Q34897103The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus
Q33586289Using Pulmozyme DNase treatment in lentiviral vector production

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