Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice.

scientific article published on 28 July 2016

Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/MOLEHR/GAW051
P932PMC publication ID5099998
P698PubMed publication ID27470502

P50authorRod T MitchellQ38642118
P2093author name stringNorah Spears
Federica Lopes
Sophie Nash
Rowena Smith
P2860cites workHow do chemotherapeutic agents damage the ovary?Q28267696
Impact of cancer therapies on ovarian reserveQ28384958
Phase 1 evaluation of EZN-2208, a polyethylene glycol conjugate of SN38, in children adolescents and young adults with relapsed or refractory solid tumorsQ33416097
Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory moleculesQ33564776
Fertility preservation for cancer patients: a reviewQ33771927
Spermatogonial stem cells in higher primates: are there differences from those in rodents?Q33956993
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Docetaxel induces moderate ovarian toxicity in mice, primarily affecting granulosa cells of early growing folliclesQ34230276
Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation.Q34380985
The impact of chemotherapy on male fertility: a survey of the biologic basis and clinical aspectsQ34460125
Cisplatin and doxorubicin induce distinct mechanisms of ovarian follicle loss; imatinib provides selective protection only against cisplatinQ34905992
Phase I dose escalation and pharmacokinetic study of oral gefitinib and irinotecan in children with refractory solid tumorsQ36036684
Understanding Fertility in Young Female Cancer PatientsQ36218039
Relationship between spermatogonial stem cell survival and testis function after cytotoxic therapyQ36291386
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Effects of chemotherapy and radiotherapy on spermatogenesis in humansQ37305907
Male fertility and strategies for fertility preservation following childhood cancer treatment.Q37417040
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What lies behind chemotherapy-induced ovarian toxicity?Q38015240
Infertility in reproductive-age female cancer survivors.Q38343285
Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults.Q38420984
A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boysQ38584517
Effect of childhood acute lymphoblastic leukemia therapy on spermatogonia populations and future fertilityQ39992776
Development and characterization of a novel liposome-based formulation of SN-38.Q40599002
Reproduction post-chemotherapy in young cancer patientsQ40729855
RNA-seq reveals determinants for irinotecan sensitivity/resistance in colorectal cancer cell linesQ41138517
Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal ratsQ41564520
Male fertility in long-term survivors of childhood acute lymphoblastic leukaemiaQ41960781
Testicular histology and function following long-term chemotherapy of acute leukemia in children and outcome of the patients who received testicular biopsy.Q43883704
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Clinical pharmacokinetics of irinotecan and its metabolites: a population analysisQ44083716
Long-term survival of human spermatogonial stem cells in mouse testesQ44245848
Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing and soft tissue sarcomasQ44943988
Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescenceQ44990547
A phase I study of irinotecan administered on a weekly schedule in pediatric patientsQ46379409
Irinotecan HCl, an anticancer topoisomerase I inhibitor, frequently induces ovarian failure in premenopausal and perimenopausal womenQ46634287
A novel molecular mechanism for anticancer drug-induced ovarian failure: Irinotecan HCl, an anticancer topoisomerase I inhibitor, induces specific FasL expression in granulosa cells of large ovarian follicles to enhance follicular apoptosisQ46634345
The radiation-induced block in spermatogonial differentiation is due to damage to the somatic environment, not the germ cells.Q50704788
Ovarian reserve after treatment with alkylating agents during childhoodQ61183133
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11Q68248525
Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCFQ73685417
Topoisomerase-I inhibitor SN-38 can induce DNA damage and chromosomal aberrations independent from DNA synthesisQ77703627
Cortical fibrosis and blood-vessels damage in human ovaries exposed to chemotherapy. Potential mechanisms of ovarian injuryQ79836914
Estimation of nuclear population from microtome sectionsQ82126847
P4510describes a project that usesImageJQ1659584
P433issue11
P921main subjectirinotecanQ412197
P304page(s)745-755
P577publication date2016-07-28
P1433published inMolecular Human ReproductionQ15761794
P1476titleIrinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice
P478volume22

Reverse relations

cites work (P2860)
Q48147030Chemotherapy drugs cyclophosphamide, cisplatin and doxorubicin induce germ cell loss in an in vitro model of the prepubertal testis
Q92740894Comparative gonadotoxicity of the chemotherapy drugs cisplatin and carboplatin on prepubertal mouse gonads
Q89862409Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility
Q58599829How does chemotherapy treatment damage the prepubertal testis?
Q100533819Poly (ADP-ribose) polymerase inhibitor exposure reduces ovarian reserve followed by dysfunction in granulosa cells
Q40494116Relationship between UGT1A1*6/*28 gene polymorphisms and the efficacy and toxicity of irinotecan-based chemotherapy
Q91842079Single and combined effects of cisplatin and doxorubicin on the human and mouse ovary in vitro

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