Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence

scientific article published on 31 August 2016

Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1534/G3.116.033969
P932PMC publication ID5100844
P698PubMed publication ID27587298

P2093author name stringJoseph T Nickels
Caroline Giordano
Josie E Parker
Steven L Kelly
Hsing-Yin Liu
Christina Gallo-Ebert
Melissa Donigan
Adam Bata
Paula McCourt
P2860cites workPlasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathwayQ27932915
Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulumQ27933944
Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1.Q27933964
Cell surface polarization during yeast matingQ27934709
Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiaeQ27936292
Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiaeQ27937712
An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiaeQ27938737
Arv1 regulates PM and ER membrane structure and homeostasis but is dispensable for intracellular sterol transport.Q27939674
Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1.Q27940092
Clinical perspectives on echinocandin resistance among Candida speciesQ28082538
Lipid rafts and signal transductionQ28131735
Sterol esterification in yeast: a two-gene processQ28280662
Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulenceQ28472787
Novel insights into disseminated candidiasis: pathogenesis research and clinical experience convergeQ33320193
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agentsQ33689421
The impact of Staphylococcus aureus-associated molecular patterns on staphylococcal superantigen-induced toxic shock syndrome and pneumoniaQ33850007
Hyphal guidance and invasive growth in Candida albicans require the Ras-like GTPase Rsr1p and its GTPase-activating protein Bud2pQ33884544
Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450Q33976263
Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions.Q33991500
Growth of Candida albicans hyphaeQ34208335
Lipid raft polarization contributes to hyphal growth in Candida albicansQ34361022
The putative lipid transporter, Arv1, is required for activating pheromone-induced MAP kinase signaling in Saccharomyces cerevisiaeQ34537552
Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeastQ34588776
Candida albicans hyphal initiation and elongationQ34633128
Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein responseQ34752008
Strain-dependent differences in host response to Candida albicans infection in mice are related to organ susceptibility and infectious load.Q35493257
Roles of Candida albicans Dfg5p and Dcw1p cell surface proteins in growth and hypha formationQ35613161
Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungiQ35754204
Animal models in the analysis of Candida host-pathogen interactionsQ35853291
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiaeQ36076499
Sterol homeostasis in the budding yeast, Saccharomyces cerevisiaeQ36083618
Candida, still number one--what do we know and where are we going from there?Q36123883
Requirement for Candida albicans Sun41 in biofilm formation and virulence.Q36314193
The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.Q37075845
BAR domain proteins Rvs161 and Rvs167 contribute to Candida albicans endocytosis, morphogenesis, and virulenceQ37333447
CERT-mediated trafficking of ceramideQ37470995
Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factorQ37568906
A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistanceQ37583600
Staphylococcal superantigen super-domains in immune evasionQ37724915
Beyond ergosterol: linking pH to antifungal mechanismsQ37823114
Importance of the Candida albicans cell wall during commensalism and infection.Q38011517
Candida glabrata: a review of its features and resistanceQ38163927
Echinocandin resistance, susceptibility testing and prophylaxis: implications for patient managementQ38254290
Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120.Q38279993
Azole resistance in CandidaQ38970335
Plasma membrane polarization during mating in yeast cellsQ39730581
Contribution of cysteine residue to the properties of Listeria monocytogenes listeriolysin O.Q39771081
Multi-organ failure in a previously healthy 10-year-old boy: streptococcal toxic shock syndrome (STSS) - a rare differential diagnosisQ40356207
Nosocomial candidiasis: emerging species, reservoirs, and modes of transmissionQ41044976
Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicansQ43173427
The vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans and its enhancement by allicinQ43252106
Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiaeQ43990141
The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals.Q45978051
Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutationsQ46792595
Arabidopsis thaliana expresses two functional isoforms of Arvp, a protein involved in the regulation of cellular lipid homeostasisQ48087371
Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.Q54179857
Immunomodulation by Candida albicans: crucial role of organ colonization and chronic infection with an attenuated agerminative strain of C. albicans for establishment of anti-infectious protection.Q54377722
Candida Urinary Tract Infection: PathogenesisQ58838308
Determination of the membrane topology of Arv1 and the requirement of the ER luminal region for Arv1 function in Saccharomyces cerevisiaeQ84025753
Toxic shock syndrome toxinQ93619137
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
P577publication date2016-08-31
P1433published inG3Q5512701
P1476titleProper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence

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cites work (P2860)
Q58799783Localization and functional characterization of the pathogenesis-related proteins Rbe1p and Rbt4p in Candida albicans
Q62896818The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B
Q28818537Widespread Genetic Incompatibilities between First-Step Mutations during Parallel Adaptation of Saccharomyces cerevisiae to a Common Environment

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