Role of trastuzumab in the adjuvant treatment of HER2-positive early breast cancer

scientific article published on March 2009

Role of trastuzumab in the adjuvant treatment of HER2-positive early breast cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2217/17455057.5.2.135
P698PubMed publication ID19245352

P2093author name stringCharles E Geyer
Bushra Haq
P2860cites workUse of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study groupQ27824835
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancerQ27824847
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Untangling the ErbB signalling networkQ27860884
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathyQ28593656
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trialsQ29547513
Trastuzumab--mechanism of action and use in clinical practiceQ29615810
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerQ29616112
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancerQ29617440
Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-23.Q31960126
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trialQ33724456
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunitiesQ34399306
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancerQ34496969
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factorsQ36334739
Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenograftsQ40318915
Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1.Q40335378
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cellsQ40344963
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancerQ40554269
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.Q40571024
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic diseaseQ40630247
Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial.Q42626922
Results of two open-label, multicenter phase II studies of docetaxel, platinum salts, and trastuzumab in HER2-positive advanced breast cancer.Q42627458
ErbB2 is essential in the prevention of dilated cardiomyopathy.Q43976647
Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.Q44362100
Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithmQ44529239
The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27.Q44618276
Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patientsQ46464385
Paclitaxel after doxorubicin plus cyclophosphamide as adjuvant chemotherapy for node-positive breast cancer: results from NSABP B-28.Q46493659
Comparison of HER2 status by fluorescence in situ hybridization and immunohistochemistry to predict benefit from dose escalation of adjuvant doxorubicin-based therapy in node-positive breast cancer patientsQ46580491
HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissuesQ47612892
HER-2 testing in breast cancer using parallel tissue-based methodsQ47685189
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.Q53243856
P433issue2
P921main subjecttrastuzumabQ412616
P304page(s)135-147
P577publication date2009-03-01
P1433published inWomen's HealthQ15762155
P1476titleRole of trastuzumab in the adjuvant treatment of HER2-positive early breast cancer
P478volume5

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Q37699356Stem cells of the breast and cancer therapycites workP2860

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