TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation

scientific article

TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1302229
P932PMC publication ID3870476
P698PubMed publication ID24244024
P5875ResearchGate publication ID258639241

P2093author name stringQingxian Lu
Jixiang Ding
Yan Zheng
Qiutang Li
Rui Ji
Xiaomin Wang
Qingjun Lu
Shifu Tian
Helen J Lu
P2860cites workSuppressor of Cytokine Signaling-1 Is Essential for Suppressing Dendritic Cell Activation and Systemic AutoimmunityQ79073423
A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microgliaQ79755044
Differential activation of astrocytes by innate and adaptive immune stimuliQ80990228
Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathwaysQ82705613
Age-related neuroinflammatory changes negatively impact on neuronal functionQ21128630
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injuryQ21245237
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRsQ24303416
Adult neurogenesis in the mammalian brain: significant answers and significant questionsQ24628935
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced deathQ24644712
Neurons born in the adult dentate gyrus form functional synapses with target cellsQ24648754
Hippocampal neurogenesis in adult Old World primatesQ24684091
Inflammation, mitochondria, and the inhibition of adult neurogenesisQ26860239
Microglial interactions with synapses are modulated by visual experienceQ27322943
Toll-like receptorsQ27860671
NF-kappaB regulation in the immune systemQ28205043
Neurogenesis in the adult human hippocampusQ28288339
Brain inflammation and adult neurogenesis: the dual role of microgliaQ28288892
Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cellsQ28505743
Twist mediates suppression of inflammation by type I IFNs and AxlQ28509359
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cellsQ28509872
Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodelingQ28513114
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 familyQ28585446
Tyro-3 family receptors are essential regulators of mammalian spermatogenesisQ28585555
TAM receptors are pleiotropic inhibitors of the innate immune responseQ28592484
Microglia: active sensor and versatile effector cells in the normal and pathologic brainQ29547240
Mechanisms and functional implications of adult neurogenesisQ29547295
Mammalian neural stem cellsQ29547657
Mechanisms underlying inflammation in neurodegenerationQ29617977
Functional neurogenesis in the adult hippocampusQ29618708
Inflammatory Blockade Restores Adult Hippocampal NeurogenesisQ29619037
Inflammation is detrimental for neurogenesis in adult brainQ29619040
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?Q29619386
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminalsQ29619476
Astrocytes are active players in cerebral innate immunityQ29620562
Neurogenesis in the adult is involved in the formation of trace memoriesQ29622890
Spatial relational memory requires hippocampal adult neurogenesisQ33338471
New nerve cells for the adult brainQ33610119
Immunobiology of the TAM receptorsQ33796991
Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous systemQ33914948
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.Q33931826
Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).Q33934033
Phagocytosis and clearance of apoptotic cells is mediated by MER.Q33946282
Regulation of innate immune responses in the brainQ37492253
Heterogeneity of CNS myeloid cells and their roles in neurodegenerationQ37939514
Immune surveillance in the central nervous systemQ38029971
Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharideQ38301889
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.Q40177595
Microglia instruct subventricular zone neurogenesisQ40231614
Disturbed distribution of proliferative brain cells during lupus-like diseaseQ42283209
Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.Q42501630
An endogenous vitamin K-dependent mechanism regulates cell proliferation in the brain subventricular stem cell nicheQ42721885
Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged miceQ43119214
Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6.Q43850180
Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines.Q45269970
Neuroscience. Brain under surveillance: the microglia patrolQ46601676
Tumor necrosis factor-alpha and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor cultureQ46626966
In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia.Q46815050
Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic systemQ48473463
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responsesQ48562222
Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.Q48691176
Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.Q48741510
A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.Q54102022
Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation.Q54405368
TAM receptor function in the retinal pigment epitheliumQ56878898
Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microgliaQ74139800
The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNSQ77846814
Irradiation induces neural precursor-cell dysfunctionQ34142734
Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult miceQ34192220
Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat.Q34206312
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adultQ34394410
Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective.Q34418439
Neuronal injury in bacterial meningitis: mechanisms and implications for therapyQ34500860
MAP kinases in the immune responseQ34542231
Synapse formation on neurons born in the adult hippocampus.Q34626268
Toll-like receptors modulate adult hippocampal neurogenesisQ34664161
A role for adult TLX-positive neural stem cells in learning and behaviourQ34743630
Inflammation in neurodegenerative disease--a double-edged swordQ34775762
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factorsQ34791180
Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell deathQ34804259
Stem cell biology of the central nervous systemQ34805839
Macrophage regulation by Tyro 3 family receptorsQ35031954
Interleukin-15 regulates proliferation and self-renewal of adult neural stem cellsQ35041585
A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuliQ35061225
Molecular insights on the cerebral innate immune systemQ35077014
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)Q35124699
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathwayQ35168537
TAM receptor knockout mice are susceptible to retinal autoimmune inductionQ35220895
Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout miceQ35307873
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cellsQ35615917
Adult murine hippocampal neurogenesis is inhibited by sustained IL-1β and not rescued by voluntary running.Q35672842
Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategyQ35683415
The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative diseaseQ35841846
Unique processing during a period of high excitation/inhibition balance in adult-born neurons.Q36064695
Role of inflammation in neurodegenerative diseasesQ36125754
Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinaseQ36371130
Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neuronsQ36439979
Induction of inhibitory factor kappaBalpha mRNA in the central nervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the ratQ36603949
Cytokine control of adult neural stem cellsQ37399352
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.Q37424811
Immune influence on adult neural stem cell regulation and functionQ37460790
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectneurogenesisQ1456827
microgliaQ1622829
P304page(s)6165-6177
P577publication date2013-11-15
P1433published inJournal of ImmunologyQ3521441
P1476titleTAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation
P478volume191

Reverse relations

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