Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees

scientific article published on 17 September 2009

Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2009-05-223263
P932PMC publication ID2777127
P698PubMed publication ID19762487
P5875ResearchGate publication ID26820077

P2093author name stringShoshana Levy
Ronald Levy
Adam Widman
John Timmerman
Debra K Czerwinski
Bindu Varghese
Behnaz Taidi
James Do
P2860cites workCpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populationsQ33193071
Humoral immune response and immunoglobulin G Fc receptor genotype are associated with better clinical outcome following idiotype vaccination in follicular lymphoma patients regardless of their response to induction chemotherapyQ35616042
Idiotype variant cell populations in patients with B cell lymphomaQ36353115
Therapy of lymphoma directed at idiotypesQ36577582
TLR9 as a key receptor for the recognition of DNA.Q37080471
FcR gamma chain deletion results in pleiotrophic effector cell defectsQ38311129
CpG stimulation of precursor B-lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells toward a Th1 responseQ38332055
Sulfhydryl-based tumor antigen-carrier protein conjugates stimulate superior antitumor immunity against B cell lymphomasQ39943861
Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40.Q40372837
Signaling via the anti-CD30 mAb SGN-30 sensitizes Hodgkin's disease cells to conventional chemotherapeuticsQ40392451
Fenretinide enhances rituximab-induced cytotoxicity against B-cell lymphoma xenografts through a caspase-dependent mechanism.Q40604062
Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein.Q41660798
Membrane IgM, IgD, and IgG act as signal transmission molecules in a series of B lymphomas.Q42819617
Monoclonal anti-idiotype antibodies against the murine B cell lymphoma 38C13: characterization and use as probes for the biology of the tumor in vivo and in vitroQ43949524
Monoclonal anti-idiotype antibody therapy of B-cell lymphoma: the addition of a short course of chemotherapy does not interfere with the antitumor effect nor prevent the emergence of idiotype-negative variant cellsQ44263369
CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptorQ47722565
Anti-idiotype antibodies can induce long-term complete remissions in non-Hodgkin's lymphoma without eradicating the malignant clone.Q47725344
Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphomaQ48369391
Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity.Q54702413
[Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody]Q68093668
Regulation of an idiotype+ B cell lymphoma. Effects of antigen and anti-idiotopic antibodies on proliferation and Ig secretionQ68094611
Importance of antibody isotype in monoclonal anti-idiotype therapy of a murine B cell lymphoma. A study of hybridoma class switch variantsQ68792567
Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with alpha interferonQ69053865
A clinical trial of anti-idiotype therapy for B cell malignancyQ69891840
Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype AntibodyQ72657705
Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphomaQ73235550
Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cellsQ73386737
CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigensQ73492223
Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodiesQ74213454
CpG oligodeoxynucleotides enhance monoclonal antibody therapy of a murine lymphomaQ77167886
Immunomodulatory oligonucleotides as novel therapy for breast cancer: pharmacokinetics, in vitro and in vivo anticancer activity, and potentiation of antibody therapyQ80159179
Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itselfQ80736139
CpG oligonucleotides enhance the tumor antigen-specific immune response of an anti-idiotype antibody-based vaccine strategy in CEA transgenic miceQ80934188
B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotidesQ81474815
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)4477-4485
P577publication date2009-09-17
P1433published inBloodQ885070
P1476titleGeneration of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees
P478volume114

Reverse relations

cites work (P2860)
Q43249169Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms.
Q36891034Depleting tumor-specific Tregs at a single site eradicates disseminated tumors
Q47940254Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges.
Q34194680In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study
Q90257528Intratumoral Immunotherapy-Update 2019
Q47281370Intratumoral immunotherapy: using the tumor as the remedy
Q38358045Paradigm shift in oncology: targeting the immune system rather than cancer cells
Q38174058Radioimmunotherapy combined with maintenance anti-CD20 antibody may trigger long-term protective T cell immunity in follicular lymphoma patients.
Q36850457TLR agonists: our best frenemy in cancer immunotherapy
Q37863518Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies

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