Emergent gene order in a model of modular polyketide synthases

scholarly article

Emergent gene order in a model of modular polyketide synthases is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..10619410C
P356DOI10.1073/PNAS.0902364106
P932PMC publication ID2780807
P698PubMed publication ID19864629
P5875ResearchGate publication ID38043702

P2093author name stringBenjamin Callahan
Boris I Shraiman
Mukund Thattai
P2860cites workSelfish operons: horizontal transfer may drive the evolution of gene clustersQ24533213
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The structure of docking domains in modular polyketide synthasesQ27641953
Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking DomainsQ27653436
Evolution of polyketide synthases in bacteriaQ28267392
Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilisQ28469055
Measuring genome evolutionQ28776160
Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virusQ30376865
Natural products--a simple model to explain chemical diversityQ30980990
Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces speciesQ31105620
Combinatorial biosynthesis for drug developmentQ33286975
The origins of specificity in polyketide synthase protein interactionsQ33301008
Molecular genetics of bacteriophage P22Q33622562
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthaseQ33829840
The origins and ongoing evolution of virusesQ34106581
Polyketide biosynthesis: a millennium reviewQ34362914
From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation.Q34949551
Complete genetic linkage can subvert natural selectionQ35748721
The evolution of gene collectives: How natural selection drives chemical innovation.Q36534513
Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids.Q36772380
Competition between recombination and epistasis can cause a transition from allele to genotype selectionQ37167732
Theoretical considerations and computational analysis of the complexity in polyketide synthesis pathways.Q40408122
Population genetic perspectives on the evolution of recombination.Q41291263
Deleterious mutations, variable epistatic interactions, and the evolution of recombination.Q41486670
Genomic sequences of bacteriophages HK97 and HK022: pervasive genetic mosaicism in the lambdoid bacteriophagesQ42628295
4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acidQ43394722
A theory of modular evolution for bacteriophagesQ43948704
Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modulesQ46203484
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.Q46449284
Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes.Q51918539
Evolution of prokaryotic gene order: genome rearrangements in closely related species.Q52542073
Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster.Q54478342
Highly Variable Mutation Rates in Commensal and Pathogenic Escherichia coliQ56944671
Dissecting and exploiting intermodular communication in polyketide synthasesQ77330305
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)19410-19415
P577publication date2009-10-28
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEmergent gene order in a model of modular polyketide synthases
P478volume106

Reverse relations

cites work (P2860)
Q38172793A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides.
Q67998952Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli
Q38156708Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides
Q37755983Biosynthesis and molecular genetics of polyketides in marine dinoflagellates.
Q35811261Development of modularity in the neural activity of children's brains
Q47168944Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.
Q28681124Evolution and distribution of saxitoxin biosynthesis in dinoflagellates
Q39814014Evolutionary dynamics of modular polyketide synthases, with implications for protein design and engineering.
Q34173936Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
Q27310283Mutation rules and the evolution of sparseness and modularity in biological systems
Q40491137Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching
Q38189999Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases
Q35771458Quasispecies theory for evolution of modularity.
Q33688865Rate of adaptation in large sexual populations
Q100518497Shared PKS Module in Biosynthesis of Synergistic Laxaphycins
Q27320756Structure and evolution of Streptomyces interaction networks in soil and in silico
Q28648024The emergence of modularity in biological systems
Q53316686Undesired usage and the robust self-assembly of heterogeneous structures.

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