Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells

scientific article published on 13 August 2009

Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.041020
P932PMC publication ID2781436
P698PubMed publication ID19679653

P50authorMarcello MaggioliniQ37841526
Amalia CarpinoQ39718445
Vincenzo PezziQ57119424
Rosa SirianniQ58895730
P2093author name stringAdele Chimento
Arianna De Luca
Fabiana Zolea
Sebastiano Andò
Vittoria Rago
P2860cites workProliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disordersQ24538593
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Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells.Q40462696
A steroidogenic factor-1-binding site and cyclic adenosine 3',5'-monophosphate response element-like elements are required for the activity of the rat aromatase promoter in rat Leydig tumor cell linesQ40991904
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Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesisQ41709477
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Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation.Q53529918
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Functional interactions, phosphorylation, and levels of 3',5'-cyclic adenosine monophosphate-regulatory element binding protein and steroidogenic factor-1 mediate hormone-regulated and constitutive expression of aromatase in gonadal cellsQ73127768
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P433issue42
P407language of work or nameEnglishQ1860
P304page(s)28905-28916
P577publication date2009-08-13
P1433published inJournal of Biological ChemistryQ867727
P1476titleInhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells
P478volume284

Reverse relations

cites work (P2860)
Q26851667Cyclooxygenase and prostaglandins in somatic cell populations of the testis
Q39701916Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cells
Q34514569Deletion of EP4 on Bone Marrow–Derived Cells Enhances Inflammation and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation
Q40290479Downregulation of prostaglandin E2 is involved in hindgut mucosal damage in lactating goats fed a high-concentrate diet
Q42049244Elevated levels of the steroidogenic factor 1 are associated with over-expression of CYP19 in an oestrogen-producing testicular Leydig cell tumour
Q26865327GPER Signaling in Spermatogenesis and Testicular Tumors
Q36326358GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo
Q36099670Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women
Q53295839Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long-term experiment.
Q39504547Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system.
Q36171080Overexpression of CYP19A1 aromatase in Leydig cells is associated with steroidogenic dysfunction in subjects with Sertoli cell-only syndrome.
Q28567192Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells
Q35733386Teasing out the role of aromatase in the healthy and diseased testis.

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