Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

scientific article

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2016NatCo...713496B
P356DOI10.1038/NCOMMS13496
P932PMC publication ID5123088
P698PubMed publication ID27882918

P50authorFrances AshcroftQ5478504
Patrik RorsmanQ18440416
Benjamin GlaserQ55719492
Maria RohmQ60057808
P2093author name stringAnne Clark
Kenju Shimomura
Sheena Lee
Yuval Dor
Daniela Dadon
Melissa F Brereton
Michaela Iberl
Margarita V Chibalina
Sharona Tornovsky-Babeay
Christian Holland
P2860cites workActivating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetesQ24338339
Inhibition of macroautophagy triggers apoptosisQ24338482
β-cell dedifferentiation in diabetes is important, but what is it?Q27011272
Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase bQ27731947
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
Triggering and amplifying pathways of regulation of insulin secretion by glucoseQ27863677
Metabolism of glucose in the islets of LangerhansQ69840926
Glycogen in pancreatic islets of steroid diabetic rats. Carbohydrate histochemical detection and localization using an immunocytochemical techniqueQ70214125
Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cellsQ71786241
Influence of long-term diabetes on renal glycogen metabolism in the ratQ73431013
ELECTRON MICROSCOPY OF GLYCOGENQ76898701
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetesQ77726465
Role of glycogen metabolism in pancreatic islet beta cell functionQ88216028
Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2.Q45142819
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.Q45227245
Pancreatic beta-cell mass in European subjects with type 2 diabetesQ46332814
Glycogen accumulation in renal tubules, a key morphological change in the diabetic rat kidneyQ46535863
The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to maladyQ48555497
Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease.Q50480523
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.Q50646471
Possible role of glycogen accumulation in B-cell glucotoxicityQ68228297
Apoptosis of tubular epithelial cells in glycogen nephrosis during diabetesQ28565375
The Beclin 1 network regulates autophagy and apoptosisQ29616539
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
The role of glucose 6‐phosphate in the control of glycogen synthaseQ30470713
A 'picturesque' case of transition from subcutaneous to oral treatment in neonatal diabetesQ33628687
Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicityQ33944212
Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetesQ33944267
Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM).Q33966703
Reversible changes in pancreatic islet structure and function produced by elevated blood glucoseQ34086567
In-depth annotation of SNPs arising from resequencing projects using NGS-SNPQ34194748
Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes.Q34233398
Sulphonylurea action revisited: the post-cloning era.Q35159821
Glycogen infiltration (so-called hydropic degeneration) in the pancreas in human and experimental diabetes mellitusQ35921130
Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora diseaseQ36038840
The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutationQ36188411
Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapyQ36241098
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failureQ36241895
Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetesQ36270927
Deleterious effects of neuronal accumulation of glycogen in flies and miceQ36386453
Glycogen autophagy in glucose homeostasisQ36510005
Evidence of β-Cell Dedifferentiation in Human Type 2 DiabetesQ36716120
Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell functionQ36756546
Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.Q36908155
Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cellsQ36966837
Physicochemical changes in phosphorylase kinase associated with its activationQ36990635
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetesQ37036031
Glycogen and its metabolism: some new developments and old themesQ37095413
Regulation of mitochondrial dehydrogenases by calcium ionsQ37469373
Role of autophagy in β-cell function and massQ37804449
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagyQ38974302
Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitusQ39985807
Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapyQ41054906
Permeability of intestinal capillaries. Pathway followed by dextrans and glycogensQ41154258
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemiaQ42442810
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat dietQ42442818
Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasisQ42488289
Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes.Q44393971
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cellsQ44439906
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthyperglycemiaQ271993
glycogen metabolic processQ14902477
P304page(s)13496
P577publication date2016-11-24
P1433published inNature CommunicationsQ573880
P1476titleHyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
P478volume7