CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.

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CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1068965638
P356DOI10.2119/MOLMED.2013.00140
P932PMC publication ID3883962
P698PubMed publication ID24408112

P50authorPhilippe MarambaudQ30420124
Valérie VingtdeuxQ30421269
P2093author name stringPeter Davies
Cristina d'Abramo
Rachel Friedman
Jeremy Koppel
Heidy Jimenez
Mark Stauber
P2860cites workStimulation of cannabinoid receptor 2 (CB2) suppresses microglial activationQ21245246
Microglia and neuroinflammation: a pathological perspectiveQ24799838
Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathwaysQ26830542
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse modelQ28115206
Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brainsQ28189423
Microglia-specific localisation of a novel calcium binding protein, Iba1Q28273977
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathwayQ28571359
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formationQ29616564
Gene expression as peripheral biomarkers for sporadic Alzheimer's disease.Q51774412
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cellsQ61479730
Marijuana, immunity and infectionQ74608042
Techniques of image analysis for quantitative immunohistochemistryQ81243040
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice.Q30506148
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.Q31840691
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.Q33726605
Targeting the endocannabinoid system in Alzheimer's disease.Q33930000
LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 miceQ34173381
Alzheimer's disease in man and transgenic mice: females at higher riskQ34174531
Epigenetic regulation of fatty acid amide hydrolase in Alzheimer diseaseQ34312272
Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.Q34397288
{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.Q34635580
Attenuation of allergic contact dermatitis through the endocannabinoid systemQ34635629
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's diseaseQ35167904
Microglia and Alzheimer's disease pathogenesisQ35805628
Cannabinoid-based drugs as anti-inflammatory therapeuticsQ36111923
Sensitive quantitative assays for tau and phospho-tau in transgenic mouse modelsQ36328476
The peripheral cannabinoid receptor knockout mice: an updateQ36416347
Targeting the CB2 receptor for immune modulationQ36596663
Heterogeneity of CNS myeloid cells and their roles in neurodegenerationQ37939514
Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathologyQ38061480
Comparison analysis of gene expression patterns between sporadic Alzheimer's and Parkinson's diseaseQ38294479
Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studiesQ41612685
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.Q43266820
CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patientsQ43460178
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptorQ43503403
CB2 cannabinoid receptor agonist ameliorates Alzheimer-like phenotype in AβPP/PS1 mice.Q44094824
Inflammation occurs early during the Abeta deposition process in TgCRND8 miceQ44948592
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasomeQ45007178
Drugs and immunity: cannabinoids and their role in decreased resistance to infectious diseaseQ45111716
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.Q46303283
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tanglesQ46332461
Abnormal processing of tau in the brain of aged TgCRND8 mice.Q48094292
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic agingQ48156883
Activation of the CB2 receptor system reverses amyloid-induced memory deficiencyQ48440561
Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer diseaseQ48656375
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)357-364
P577publication date2013-11-08
P1433published inMolecular MedicineQ6895961
P1476titleCB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease
P478volume19

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cites work (P2860)
Q26746050CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease
Q35667387Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation
Q38748394Cannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others?
Q38593120Genetic Manipulation of the Endocannabinoid System
Q38395251New approaches in the design and development of cannabinoid receptor ligands: multifunctional and bivalent compounds
Q92719134Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists

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