Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy

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Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1016636270
P356DOI10.1186/CC8010
P932PMC publication ID2786114
P698PubMed publication ID19951384
P5875ResearchGate publication ID51440253

P50authorCan InceQ92757506
P2093author name stringPaolo Pelaia
Rick Bezemer
Laura Botticelli
Abele Donati
Vincenzo Gabbanelli
Agnese Valentini
Michela Romanelli
Simonetta Nataloni
Tiziana Principi
P2860cites workThe microcirculation is the motor of sepsisQ24633735
Efficacy and safety of recombinant human activated protein C for severe sepsisQ29547839
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsisQ30493116
Regional microvascular function and vascular reactivity in patients with different degrees of multiple organ dysfunction syndrome.Q33237218
The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shockQ33433376
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shockQ34314380
Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease.Q34321275
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.Q35094247
New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated).Q36259602
Near infrared spectroscopy for evaluation of the trauma patient: a technology reviewQ36329886
Impairments in microvascular reactivity are related to organ failure in human sepsisQ40215829
Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.Q40466365
Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxideQ43727878
Microvascular blood flow is altered in patients with sepsisQ44045816
Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shockQ45283334
Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stressQ46643306
Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemiaQ47797708
Activated protein C reduces tissue hypoxia, inflammation, and apoptosis in traumatized skeletal muscle during endotoxemia.Q54439750
DYNAMIC NEAR-INFRARED SPECTROSCOPY MEASUREMENTS IN PATIENTS WITH SEVERE SEPSISQ61651190
The prognostic value of muscle StO2 in septic patientsQ64126793
Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsisQ64126881
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment*Q64126934
Microvascular function and rheologic changes in hyperdynamic sepsisQ72571917
Nitroglycerin in septic shock after intravascular volume resuscitationQ78494402
Changes in muscle tissue oxygenation during stagnant ischemia in septic patientsQ81425041
P921main subjectinfrared spectroscopyQ70906
sepsisQ183134
drotrecogin alfaQ412888
P304page(s)S12
P577publication date2009-11-30
P1433published inCritical CareQ5186602
P1476titleRecombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy
P478volume13 Suppl 5

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cites work (P2860)
Q53271048Comparison of two devices using near-infrared spectroscopy for the measurement of tissue oxygenation during a vascular occlusion test in healthy volunteers (INVOS® vs. InSpectra™).
Q42258423From macrohemodynamic to the microcirculation
Q37929901Microcirculatory alterations: potential mechanisms and implications for therapy
Q26798312Microcirculatory dysfunction and resuscitation: why, when, and how
Q37356648Near-infrared spectroscopy StO2 monitoring to assess the therapeutic effect of drotrecogin alfa (activated) on microcirculation in patients with severe sepsis or septic shock
Q37302256Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study
Q26851227Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock
Q35560929Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis
Q34114355Protein targets of inflammatory serine proteases and cardiovascular disease
Q34999953The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome
Q33629515Tissue saturation measurement--exciting prospects, but standardisation and reference data still needed
Q37966024Year in review 2010: Critical Care--Cardiology

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