Systems analysis of bone

scientific article published on July 2009

Systems analysis of bone is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/WSBM.15
P932PMC publication ID2790199
P698PubMed publication ID20046860
P5875ResearchGate publication ID40834914

P2093author name stringKarl J Jepsen
P2860cites workPleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integrationQ80598418
Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2Q81527207
Genetic loci determining bone density in mice with diet-induced atherosclerosisQ95721154
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass traitQ24561917
Bone resorption by osteoclastsQ28145169
Regulation of bone mass in mice by the lipoxygenase gene Alox15Q28505413
Pleiotropy, homeostasis, and functional networks based on assays of cardiovascular traits in genetically randomized populationsQ30501139
Diaphyseal bone growth and adaptation: models and data.Q30571312
Is the genotype-phenotype map modular? A statistical approach using mouse quantitative trait loci dataQ30611760
Bone strength and related traits in HcB/Dem recombinant congenic miceQ30675858
Vertebral bone mass, size, and volumetric density in women with spinal fractures.Q30775011
Heterogeneity in the growth of the axial and appendicular skeleton in boys: implications for the pathogenesis of bone fragility in men.Q30940163
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traitsQ31008848
A time course of bone response to jump exercise in C57BL/6J miceQ31096537
The contribution of reduced peak accrual of bone and age-related bone loss to osteoporosis at the spine and hip: insights from the daughters of women with vertebral or hip fracturesQ31923479
Familial resemblance for bone mineral mass is expressed before pubertyQ32120311
Low width of tubular bones is associated with increased risk of fragility fracture in elderly men--the MINOS study.Q33225961
Structural model analysis of multiple quantitative traitsQ33250569
Construction of the femoral neck during growth determines its strength in old age.Q33284564
Bone densitometry: the best way to detect osteoporosis and to monitor therapyQ33662575
Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred miceQ33947682
The osteoblast: a sophisticated fibroblast under central surveillanceQ34021172
Circulating levels of IGF-1 directly regulate bone growth and densityQ34149771
Vertebral size in elderly women with osteoporosis. Mechanical implications and relationship to fracturesQ34218795
The developing bone: slave or master of its cells and molecules?Q34344212
Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis.Q34430468
Defining the genetics of osteoporosis: using the mouse to understand man.Q34444372
Who's afraid of the big bad Wolff?: "Wolff's law" and bone functional adaptationQ34486416
Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransductionQ34536557
Genome-wide association studies: theoretical and practical concernsQ34555195
Finding genes that underlie complex traitsQ35031309
Familial resemblance of radial bone mass between premenopausal mothers and their college-age daughtersQ35218684
Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL geneQ35757879
Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragilityQ36021383
Genetic approaches to studying common diseases and complex traitsQ36092154
Bone mineral status in childhood accidental fractures.Q36625354
Bivariate linkage study of proximal hip geometry and body size indices: the Framingham studyQ36647729
Genes in context: probing the genetics of fracture resistanceQ36875028
The cell biology of bone metabolism.Q37149159
Biological co-adaptation of morphological and composition traits contributes to mechanical functionality and skeletal fragilityQ37150659
A preliminary study of one year of pedometer self-monitoringQ38476278
Dynamic strain similarity in vertebrates; an alternative to allometric limb bone scalingQ38705754
Can metacarpal cortical area predict the occurrence of hip fracture in women and men over 3 decades of follow-up? Results from the Framingham Osteoporosis StudyQ39588682
Mapping quantitative trait loci that influence femoral cross-sectional area in miceQ39632786
Genetic dissection of inflammatory responsesQ40428124
IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo.Q40706159
Basic biomechanical measurements of bone: a tutorialQ40797364
Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart StudyQ40832005
The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twinsQ40943137
Serum levels of insulin-like growth factor I and the density, volume, and cross-sectional area of cortical bone in childrenQ41684654
Mechanical properties of bone tissues with greatly differing functionsQ41739841
Chronological changes in genetic variance and heritability of anthropometric characteristics among Chinese twin infantsQ42016424
On the Nature of Size FactorsQ42066578
Integration and modularity of quantitative trait locus effects on geometric shape in the mouse mandibleQ42426730
Gender specificity in the genetic determinants of peak bone massQ42663396
The presence of classical insulin-like growth factor (IGF) type-I and -II receptors on mouse osteoblasts: autocrine/paracrine growth effect of IGFs?Q43440301
Insulin-like growth factor-I supports formation and activation of osteoclastsQ43458688
Functional determinants of bone structure: beyond Wolff's law of bone transformationQ43941699
Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J miceQ44273627
Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 Mice: single QTL effects, epistasis, and pleiotropyQ44430053
Genetic determinants of bone mass in adult women: a reevaluation of the twin model and the potential importance of gene interaction on heritability estimatesQ44458776
Genetic loci influencing natural variations in femoral bone morphometry in miceQ46158920
Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growthQ46290684
Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activityQ46296922
Differential effect of gender on the sizes of the bones in the axial and appendicular skeletonsQ46352868
Body mass is the primary determinant of midfemoral bone acquisition during adolescent growthQ46531103
Bone "mass" and the "mechanostat": a proposal.Q53710331
Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties.Q54066961
Characterization of osteocrin expression in human bone.Q54661657
POSTMENOPAUSAL OSTEOPOROSISQ56170542
Developmental Integration and the Evolution of PleiotropyQ56506214
Familial Resemblance of Bone Mineral Density (BMD) and Calcaneal Ultrasound Attenuation: The BMD in Mothers and Daughters StudyQ57392501
Quantitative Trait Loci Affecting Peak Bone Mineral Density in MiceQ57450345
Bone adaptation requires oestrogen receptor-αQ59049437
Hindlimb suspension diminishes femoral cross-sectional growth in the ratQ60345635
Ground reaction forces, bone characteristics, and tibial stress fracture in male runnersQ61649833
Quantitative genetic analysis of bi-iliac breadthQ68035329
Telemetric force measurements across the hip after total arthroplastyQ68249800
Genetic determinants of bone mineral content at the spine and radius: a twin studyQ68695490
The area moment of inertia of the tibia: a risk factor for stress fracturesQ69448149
Osteoporosis and the risk of hip fractureQ69561677
Stress fractures and tibial bone width. A risk factorQ69753265
Reduced bone mass in daughters of women with osteoporosisQ69944287
Genetic and environmental factors in head and face measurements of Belgian twinsQ71242160
Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin studyQ71464271
Adaptation to differential loading: comparison of growth-related changes in cross-sectional properties of the human femur and humerusQ71647115
Bone mineral content in children with fracturesQ71823129
Environmental and genetic factors affecting bone mass. Similarity of bone density among members of healthy familiesQ72402084
Structural and cellular changes during bone growth in healthy childrenQ73082204
Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in miceQ73082212
Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred miceQ73169291
Dual-energy X-ray absorptiometry derived structural geometry for stress fracture prediction in male U.S. Marine Corps recruitsQ73352468
Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal womenQ73639535
Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strainsQ73711517
Genome screen for quantitative trait loci underlying normal variation in femoral structureQ73977325
Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of miceQ74192493
Stress fracture in military recruits: gender differences in muscle and bone susceptibility factorsQ74234104
Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeletonQ74558121
Bone brittleness varies with genetic background in A/J and C57BL/6J inbred miceQ74590318
Familial resemblance of bone mineral density between females 18 years and older and their mothersQ77151367
The estimation of the heritability of anthropometric measurementsQ77224503
The biomechanical basis of vertebral body fragility in men and womenQ77400480
Bone response to in vivo mechanical loading in two breeds of miceQ77503027
Family history and risk of osteoporotic fracture. Study of Osteoporotic Fractures Research GroupQ77746256
Heritability of bone mineral densityQ77749548
Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivoQ77833168
Evidence for a skeletal mechanosensitivity gene on mouse chromosome 4Q78685702
The structural and hormonal basis of sex differences in peak appendicular bone strength in ratsQ78743015
Genetic Effects for Femoral Biomechanics, Structure, and Density in C57BL/6J and C3H/HeJ Inbred Mouse StrainsQ79221813
Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and agingQ79221816
Quantitative trait loci that determine mouse tibial nanoindentation properties in an F2 population derived from C57BL/6J x C3H/HeJQ80435136
Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse populationQ80454900
Chemical mutagenesis induced two high bone density mouse mutants map to a concordant distal chromosome 4 locusQ46989561
Quantitative genetic study of radiographic hand bone size and geometryQ47172058
Understanding bone strength: size isn't everythingQ47204442
Does body size account for gender differences in femur bone density and geometry?Q47206331
Body size, body shape, and long bone strength in modern humansQ47247810
Moderate exercise during growth in prepubertal boys: changes in bone mass, size, volumetric density, and bone strength: a controlled prospective studyQ47275233
Bone mineral density and bone size in men with primary osteoporosis and vertebral fracturesQ47288957
Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred miceQ47300409
Linking structural variability in long bone diaphyses to habitual behaviors: foragers from the southern African Later Stone Age and the Andaman IslandsQ47321304
Quantitative trait loci for body size components in mice.Q47333164
Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain.Q47362579
Evidence for a major gene underlying bone size variation in the ChineseQ47433458
Growth in bone strength, body size, and muscle size in a juvenile longitudinal sampleQ47442106
Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse populationQ47444511
PHENOTYPIC, GENETIC, AND ENVIRONMENTAL MORPHOLOGICAL INTEGRATION IN THE CRANIUM.Q47590604
Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain.Q50537778
Family correlations of metacarpal bones--heritable (h2) and environmental (c2) components of total phenotypic variation.Q50912444
Segregation analysis and variance components analysis of bone mineral density in healthy families.Q51034623
Determinants of femoral geometry and structure during adolescent growth.Q51034811
Genetic factors in bone turnover.Q51611349
Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice.Q51747057
Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.Q51751358
Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes.Q51756068
QTL analysis of trabecular bone in BXD F2 and RI mice.Q51793814
Developmental integration in a complex morphological structure: how distinct are the modules in the mouse mandible?Q51946967
Sexual dimorphism of the femoral neck during the adolescent growth spurt: a structural analysis.Q52087241
A comparison of bone geometry and cortical density at the mid-femur between prepuberty and young adulthood using magnetic resonance imagingQ52097666
Pleiotropic effects on mandibular morphology I. Developmental morphological integration and differential dominance.Q52107509
Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice.Q52115495
Mechanobiology of femoral neck structure during adolescence.Q52167697
Genetic variability in adult bone density among inbred strains of mice.Q52201749
Mechanotransduction and functional response of the skeleton to physical stress: the mechanisms and mechanics of bone adaptation.Q52231687
Genes that affect morphogenesis of the murine mandible. Recombinant-inbred strain analysis.Q52262781
Congenic mice reveal sex-specific genetic regulation of femoral structure and strength.Q53636444
P433issue1
P304page(s)73-88
P577publication date2009-07-01
P1433published inWiley interdisciplinary reviews. Systems biology and medicineQ26842017
P1476titleSystems analysis of bone
P478volume1