Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

scientific article published on 16 December 2013

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PNAS..111E.119B
P356DOI10.1073/PNAS.1320777110
P932PMC publication ID3890789
P698PubMed publication ID24344267
P5875ResearchGate publication ID259350648

P50authorJohn KapplerQ905909
Philippa MarrackQ2087457
Jamie RossjohnQ28036336
Richard BerryQ56954766
Dale I GodfreyQ56957983
Laurent GapinQ62032696
Thierry MallevaeyQ62043868
Romain BedelQ114416797
Jennifer L MatsudaQ114416798
P2093author name stringJingjing Zhang
P2860cites workThe BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functionsQ24650707
The transcription factor PLZF directs the effector program of the NKT cell lineageQ24654999
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biologyQ27317219
A Molecular Basis for NKT Cell Recognition of CD1d-Self-AntigenQ27667172
A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition propertiesQ27670418
Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptorsQ27671299
Cutting Edge: Structural Basis for the Recognition of  -Linked Glycolipid Antigens by Invariant NKT CellsQ27671401
Autoreactivity by design: innate B and T lymphocytesQ28208367
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramidesQ28254991
The biology of NKT cellsQ28277482
NKT cells derive from double-positive thymocytes that are positively selected by CD1dQ28508188
Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1-deficient miceQ28509568
Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.Q33618864
The Ras/MAPK pathway is required for generation of iNKT cellsQ33900265
Sea-level fingerprinting as a direct test for the source of global meltwater pulse IA.Q34118671
T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoireQ34245603
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functionsQ34323476
iNKT cell autoreactivity: what is 'self' and how is it recognized?Q34760309
Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo.Q35850748
Toward an understanding of NKT cell biology: progress and paradoxesQ36072480
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.Q36363643
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytesQ36365532
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stageQ36370202
CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cellsQ36370736
Characterization of the early stages of thymic NKT cell developmentQ36402797
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytesQ36625423
Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cellsQ36820036
Natural Killer T cell obsession with self-antigensQ36823905
CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune systemQ36898124
Recognition of CD1d-restricted antigens by natural killer T cellsQ37088000
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cellsQ37310026
Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cellsQ38050484
Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.Q40364593
Lysosomal glycosphingolipid recognition by NKT cellsQ40493118
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.Q41005207
Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.Q41777543
NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombinationQ44623352
Long-term retention of mature NK1.1+ NKT cells in the thymus.Q52022963
Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic miceQ72037334
Noncanonical Valpha24JalphaQ T cells with conservative alpha chain CDR3 region amino acid substitutions are restricted by CD1dQ73277099
Targeted expression of human CD1d in transgenic mice reveals independent roles for thymocytes and thymic APCs in positive and negative selection of Valpha14i NKT cellsQ81512239
Natural variations at position 93 of the invariant Vα24-Jα18 α chain of human iNKT-cell TCRs strongly impact on CD1d bindingQ85010106
A thymic precursor to the NK T cell lineageQ95783850
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)E119-28
P577publication date2013-12-16
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEffective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity
P478volume111

Reverse relations

cites work (P2860)
Q36689593CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors.
Q33630962Check MAIT.
Q34510506Development of invariant natural killer T cells
Q57463916Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis
Q48261213Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.
Q41998668Endogenous lipid antigens for invariant Natural Killer T cells hold the reins in adipose tissue homeostasis
Q38837176Function and expression of CD1d and invariant natural killer T-cell receptor in the cotton rat (Sigmodon hispidus).
Q48127662Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.
Q36026142Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors
Q92129398SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection
Q91843682The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling
Q42146553The hypervariable region 4 (HV4) and position 93 of the α chain modulate CD1d-glycolipid binding of iNKT TCRs.
Q90017815The ins and outs of type I iNKT cell development
Q35143413The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function
Q35568453The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.
Q96683869Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
Q35856488Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling
Q94600452Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1+ T cell development

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