Cytotoxic and immune-mediated killing of human colorectal cancer by reovirus-loaded blood and liver mononuclear cells

scientific article

Cytotoxic and immune-mediated killing of human colorectal cancer by reovirus-loaded blood and liver mononuclear cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/IJC.27918
P932PMC publication ID3891508
P698PubMed publication ID23114986
P5875ResearchGate publication ID232744290

P50authorGiles J. ToogoodQ47319809
Graham P. CookQ50980658
Karen ScottQ56441180
Peter SelbyQ46220287
P2093author name stringRichard Vile
Hardev Pandha
Kevin J Harrington
Alan A Melcher
Matt Coffey
Fiona Errington-Mais
Robert A Adair
Sheila Fraser
P2860cites workCell carriage, delivery, and selective replication of an oncolytic virus in tumor in patientsQ24617027
Validation of a model of colon cancer progression.Q53436811
A study of human reovirus IgG and IgA antibodies by ELISA and western blotQ72108362
Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell therapy, oncolytic virotherapy and immunotherapyQ80162686
Reovirus therapy in cancer: has the orphan virus found a home?Q82623931
Clinical trials with oncolytic reovirus: moving beyond phase I into combinations with standard therapeuticsQ27690634
Junction adhesion molecule is a receptor for reovirusQ28203704
Genetic and Chemical Models of Colorectal Cancer in MiceQ33771627
Recent clinical experience with oncolytic viruses.Q34198918
Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trialQ34759406
Reovirus-induced apoptosis: A minireviewQ35135749
Cross-talk between dendritic cells and natural killer cells in viral infectionQ35988431
Innate immunity in the liverQ36036373
Drug evaluation: Reolysin--wild-type reovirus as a cancer therapeutic.Q36506689
Taming the Trojan horse: optimizing dynamic carrier cell/oncolytic virus systems for cancer biotherapyQ37120166
Tumor infection by oncolytic reovirus primes adaptive antitumor immunityQ37239555
Oncolytic viruses: a novel form of immunotherapyQ37300008
Intravenous administration of Reolysin, a live replication competent RNA virus is safe in patients with advanced solid tumorsQ37364079
Cell carriers for oncolytic viruses: Fed Ex for cancer therapyQ37582184
REO-10: a phase I study of intravenous reovirus and docetaxel in patients with advanced cancerQ37602536
Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralizationQ39578769
Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune primingQ39588655
Reciprocal human dendritic cell-natural killer cell interactions induce antitumor activity following tumor cell infection by oncolytic reovirusQ39802923
Immune-mediated antitumor activity of reovirus is required for therapy and is independent of direct viral oncolysis and replicationQ39840716
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanomaQ39874999
Reovirus activates human dendritic cells to promote innate antitumor immunityQ39990406
Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunityQ39995496
The lytic potential of human liver NK cells is restricted by their limited expression of inhibitory killer Ig-like receptorsQ40235867
Fusogenic membrane glycoprotein-mediated tumour cell fusion activates human dendritic cells for enhanced IL-12 production and T-cell primingQ40379100
A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancerQ40405703
Oncolytic reovirus against ovarian and colon cancer.Q40742634
HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on colorectal, gastric and laryngeal carcinomasQ43050854
Cellular carriers or free viruses?Q45046793
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
cytotoxicityQ246181
ReovirusQ69812835
P304page(s)2327-2338
P577publication date2012-11-26
P1433published inInternational Journal of CancerQ332492
P1476titleCytotoxic and immune-mediated killing of human colorectal cancer by reovirus-loaded blood and liver mononuclear cells
P478volume132

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cites work (P2860)
Q55464219A Phase II Study of Pelareorep (REOLYSIN®) in Combination with Gemcitabine for Patients with Advanced Pancreatic Adenocarcinoma.
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