Pain treatment with opioids : achieving the minimal effective and the minimal interacting dose

scientific article published on January 2009

Pain treatment with opioids : achieving the minimal effective and the minimal interacting dose is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.2165/0044011-200929001-00002
P698PubMed publication ID19445550

P2093author name stringPierangelo Geppetti
Silvia Benemei
P2860cites workMorphine and alternative opioids in cancer pain: the EAPC recommendationsQ24648711
Opioids: first lessons from knockout miceQ33547877
Drug interactions in palliative careQ33891507
Molecular mechanisms and regulation of opioid receptor signalingQ33932163
Opioid receptorsQ34326054
The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteersQ34397089
Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain controlQ34481299
Contribution to variability in response to opioidsQ34555917
The pharmacological importance of cytochrome CYP3A4 in the palliation of symptoms: review and recommendations for avoiding adverse drug interactionsQ34586375
Clinical pharmacology of opioids for painQ35024267
Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugsQ35040927
Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, part I.Q35078460
The fentanyl HCl patient-controlled transdermal system (PCTS): an alternative to intravenous patient-controlled analgesia in the postoperative settingQ36255041
Efficacy and safety of scheduled dosing of opioid analgesics: a quality improvement studyQ36276083
Drug interactions among commonly used medications. Chart simplifies data from critical literature reviewQ36479346
Morphine metabolites as novel analgesic drugs?Q36615743
Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addictionQ36741881
Opioid titration in cancer pain: a critical reviewQ36748760
Leukocyte-derived opioid peptides and inhibition of painQ37015399
Variations in opioid responsivenessQ37114615
Pain and the immune system.Q37132538
Standard therapy with opioids in chronic pain management : ORTIBER studyQ39300701
Plasma concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide and their relationship with analgesia and side effects in patients with cancer-related painQ39395812
Immediate- or sustained-release morphine for dose finding during start of morphine to cancer patients: a randomized, double-blind trialQ39399521
GABA in morphine analgesia and toleranceQ39494950
Drug interactions of clinical significance with opioid analgesicsQ40895607
Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphineQ41611878
Opioid purchases and expenditure in nine western European countries: 'are we killing off morphine?'.Q42657899
Opioid reward mechanisms: a key role in drug abuse?Q43070837
Trends in opioid consumption in the Nordic countries 2002-2006.Q43435244
Antidepressants increase bioavailability of morphine in cancer patientsQ43533072
Trends in the consumption of opioid analgesics in Spain. Higher increases as fentanyl replaces morphineQ44337320
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivoQ44340066
Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrationsQ44340761
Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release.Q44348612
Interactions between benzodiazepines and opioidsQ44754148
Pharmacological consequences of long-term morphine treatment in patients with cancer and chronic non-malignant painQ44862502
The MERITO Study: a multicentre trial of the analgesic effect and tolerability of normal-release oral morphine during 'titration phase' in patients with cancer painQ45037862
Is the use of transdermal fentanyl inappropriate according to the WHO guidelines and the EAPC recommendations? A study of cancer patients in ItalyQ46950147
Contribution of brainstem GABA(A) synaptic transmission to morphine analgesic toleranceQ46983237
The rise of opiophobia: is history a barrier to prescribing?Q47189299
Transdermal fentanyl: clinical pharmacology.Q51693955
Morphine and oxycodone hydrochloride in the management of cancer pain.Q51735613
Morphine in cancer pain: modes of administration. Expert Working Group of the European Association for Palliative CareQ71017710
Opioids in Italy: is marketing more powerful than the law?Q73643592
P407language of work or nameEnglishQ1860
P921main subjectopioidQ427523
P304page(s)3-16
P577publication date2009-01-01
P1433published inClinical Drug InvestigationQ15753215
P1476titlePain treatment with opioids : achieving the minimal effective and the minimal interacting dose
P478volume29 Suppl 1

Reverse relations

cites work (P2860)
Q36152849A new real-time method for detecting the effect of fentanyl using the preoperative pressure pain threshold and Narcotrend index: a randomized study in female surgery patients
Q39260209Disaster after the plaster. Fentanyl withdrawal symptoms in a curable hospice patient
Q39181539Effective Dose Titration of Fentanyl Sublingual Spray in Patients With Breakthrough Cancer Pain
Q42952523Effects of opioid rotation in chronic pain patients: ORTIBARN study
Q37599814Guidelines for prescribing opioids for chronic non-cancer pain in Korea
Q64078167Healthcare professionals' perceptions on the use of opioid analgesics for the treatment of cancer-related pain in Cyprus: A mixed-method study
Q37742613Morphine/naltrexone
Q34773536Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions
Q37776491Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.
Q39173147Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better
Q39279541Time to pain relief after immediate-release morphine in episodic pain: the TIME study.
Q37205128To predict sufentanil requirement for postoperative pain control using a real-time method: A prospective observational cohort study

Search more.