Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

scientific article published on 15 July 2004

Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.EMBOJ.7600318
P932PMC publication ID514933
P698PubMed publication ID15257288
P5875ResearchGate publication ID8452865

P50authorGregg B FieldsQ89356700
P2093author name stringHideaki Nagase
Robert Visse
Deendayal Dinakarpandian
Janelle L Lauer-Fields
Linda Chung
Naoto Yoshida
P2860cites workThe role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interactionQ24336413
On the attribution and additivity of binding energiesQ24634899
Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propellerQ27732555
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domainQ27734219
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modelingQ27860614
The ubiquitin systemQ27860803
Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activityQ28139348
A helping hand for collagenases: the haemopexin-like domainQ28275184
Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagenQ28286714
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetateQ28618372
Protein degradation and protection against misfolded or damaged proteinsQ29618400
Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistryQ29618605
The 26S proteasome: a molecular machine designed for controlled proteolysisQ29619692
How matrix metalloproteinases regulate cell behaviorQ29620360
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Q30336360
Matrix metalloproteinases: a tail of a frog that became a princeQ33337157
Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen geneQ33724444
Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant miceQ33843025
Type I collagen is thermally unstable at body temperatureQ34009096
Chain conformation in the collagen moleculeQ34213877
Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acidsQ34236661
Proteolytic response to oxidative stress in mammalian cells.Q34658976
Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exositesQ34920476
Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs)Q35572253
The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrixQ36254748
Autoimmunity to type II collagen an experimental model of arthritisQ36335891
Specific degradation of the collagen molecule by tadpole collagenolytic enzymeQ36379469
A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of laborQ37360980
Do mammalian collagenases and DNA restriction endonucleases share a similar mechanism for cleavage site recognition?Q40055712
Metalloproteinase inhibitors and the prevention of connective tissue breakdownQ40956886
Collagen/collagenase interaction: does the enzyme mimic the conformation of its own substrate?Q41006586
Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptidesQ41079349
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromoleculesQ41133261
The role of the C-terminal domain in collagenase and stromelysin specificityQ41624538
Fragments of human fibroblast collagenase. Purification and characterizationQ41874987
Fragmentation of human polymorphonuclear-leucocyte collagenaseQ42796927
The crystal and molecular structure of a collagen-like peptide with a biologically relevant sequenceQ43685581
Purification of human collagenases with a hydroxamic acid affinity columnQ44232201
A model for interstitial collagen catabolism by mammalian collagenasesQ45829596
The gelatinolytic activity of rat uterus collagenase.Q46786004
The collagen substrate specificity of human skin fibroblast collagenaseQ50335744
Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragmentsQ50335746
Gelatin: a poor substrate for a mammalian collegenase.Q53744973
Structure of CollagenQ59057538
Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinasesQ73419418
Heterotrimeric collagen peptides as fluorogenic collagenase substrates: synthesis, conformational properties, and enzymatic digestionQ73811578
Structural properties of a collagenous heterotrimer that mimics the collagenase cleavage site of collagen type IQ74343145
Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domainQ74402747
The collagenolytic activity of cathepsin K is unique among mammalian proteinasesQ77581104
THE PRESENCE OF ORGANIC PHOSPHORUS IN COLLAGENS AND GELATINSQ78243730
The molecular structure of collagenQ79062176
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)3020-3030
P577publication date2004-07-15
P1433published inThe EMBO JournalQ1278554
P1476titleCollagenase unwinds triple-helical collagen prior to peptide bond hydrolysis
P478volume23

Reverse relations

cites work (P2860)
Q37729380A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging
Q33555752Actinidain-hydrolyzed type I collagen reveals a crucial amino acid sequence in fibril formation
Q103002700Activity-dependent interdomain dynamics of matrix metalloprotease-1 on fibrin
Q26827393Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis
Q80558918Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing
Q46324397Antihypertensive properties of tilapia (Oreochromis spp.) frame and skin enzymatic protein hydrolysates.
Q38206220Bacterial collagenases - A review.
Q34407655Basis for substrate recognition and distinction by matrix metalloproteinases
Q37089575Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.
Q51055833Biochemical and Biological Attributes of Matrix Metalloproteinases.
Q34148059Biomimetic poly(ethylene glycol)-based hydrogels as scaffolds for inducing endothelial adhesion and capillary-like network formation
Q26866074Biophysical studies of matrix metalloproteinase/triple-helix complexes
Q33892014Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion
Q38650698Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β.
Q38784335Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences
Q35191039Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP
Q42176353Chain registry and load-dependent conformational dynamics of collagen
Q37608535Characterization of a novel subtilisin-like protease myroicolsin from deep sea bacterium Myroides profundi D25 and molecular insight into its collagenolytic mechanism
Q36281981Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.
Q46613985Characterization of an extracellular serine protease of Leishmania (Leishmania) amazonensis.
Q34631606Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.
Q28475366Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain
Q35447969Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1.
Q35096207Cloning of a novel collagenase gene from the gram-negative bacterium Grimontia (Vibrio) hollisae 1706B and its efficient expression in Brevibacillus choshinensis
Q24652849Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis
Q50289925Collagen type I degradation by MMP1,2,8,13, PRSS2
Q50289931Collagen type III degradation by MMP1,8,9,13
Q30579475Collagen unfolding accelerates water influx, determining hydration in the interstitial matrix
Q37012489Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway
Q93492077Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
Q39224629Conformational dynamics accompanying the proteolytic degradation of trimeric collagen I by collagenases
Q51114362Consequences of Glycine Mutations in the Fibronectin-binding Sequence of Collagen.
Q41903918Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1.
Q42376446Cross-linked dry bonding: A new etch-and-rinse technique.
Q42756684Crystal structure of an active form of human MMP-1.
Q24314926Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain
Q38266373Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.
Q88672734Current therapies in treatment and prevention of fracture wound biofilms: why a multifaceted approach is essential for resolving persistent infections
Q35489554Deficient degradation of homotrimeric type I collagen, α1(I)3 glomerulopathy in oim mice
Q36080500Defining requirements for collagenase cleavage in collagen type III using a bacterial collagen system
Q33938206Development of a gene therapy virus with a glucocorticoid-inducible MMP1 for the treatment of steroid glaucoma
Q36942459Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences
Q33618881Direct visualization of protease action on collagen triple helical structure
Q89964407Disrupted Protein Expression and Altered Proteolytic Events in Hypophosphatemic Dentin Can Be Rescued by Dentin Matrix Protein 1
Q38126397Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking
Q36563496Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds
Q35762194Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV.
Q88680079Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage
Q43192432Elastin governs the mechanical response of medial collateral ligament under shear and transverse tensile loading
Q37228551Elucidating the function of non catalytic domains of collagenases and aggrecanases
Q84609585Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2
Q36458187Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains
Q34752624Enzymatic turnover of macromolecules generates long-lasting protein-water-coupled motions beyond reaction steady state
Q47952876Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes
Q37234116Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state.
Q53541672Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.
Q48543248Fell‐Muir Lecture: Metalloproteinases: from demolition squad to master regulators
Q50790658Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.
Q38782214Gelatin promotes murine fibrosarcoma L929 cell detachment and protects the cells from TNFα-induced cytotoxicity
Q81160541Gelatinolytic activity in gingival crevicular fluid from teeth with periapical lesions
Q27334060High-speed atomic force microscopy reveals strongly polarized movement of clostridial collagenase along collagen fibrils
Q51795887Human cathepsin L, a papain-like collagenase without proline specificity.
Q36086178Identification and Characterization of Novel Matrix-Derived Bioactive Peptides: A Role for Collagenase from Santyl® Ointment in Post-Debridement Wound Healing?
Q27653978Identification and structural analysis of type I collagen sites in complex with fibronectin fragments
Q37433262Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.
Q46512477Identification, purification, and characterization of a secretory serine protease in an Indian strain of Leishmania donovani
Q27664177Implications for Collagen Binding from the Crystallographic Structure of Fibronectin 6FnI1-2FnII7FnI
Q42628541In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides.
Q38803697Inactivation of matrix-bound matrix metalloproteinases by cross-linking agents in acid-etched dentin.
Q41238049Increased Durability of Resin-Dentin Bonds Following Cross-Linking Treatment.
Q95300717Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion
Q50594628Influence of telopeptides, fibrils and crosslinking on physicochemical properties of type I collagen films.
Q92642635Integrative Approaches in Structural Biology: A More Complete Picture from the Combination of Individual Techniques
Q42089806Interdomain flexibility in full-length matrix metalloproteinase-1 (MMP-1).
Q36724874Interstitial collagen catabolism
Q37347016Intra-molecular lysine-arginine derived advanced glycation end-product cross-linking in Type I collagen: A molecular dynamics simulation study.
Q31162018Isolation and characterization of chicken bile matrix metalloproteinase.
Q39710022Liposome-mediated amplified detection of cell-secreted matrix metalloproteinase-9.
Q34232180Local conformation and dynamics of isoleucine in the collagenase cleavage site provide a recognition signal for matrix metalloproteinases.
Q34418625Localizing matrix metalloproteinase activities in the pericellular environment
Q41176062MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity
Q90480639MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation
Q37488265MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
Q24324139MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)
Q38906918Mapping intermolecular interactions and active site conformations: from human MMP-1 crystal structure to molecular dynamics free energy calculations
Q45077001Mathematical modeling of collagen turnover in biological tissue
Q36316444Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease
Q47223491Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease
Q38431602Matrix metalloproteinase collagenolysis in health and disease
Q36009930Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease
Q26996437Matrix metalloproteinase interactions with collagen and elastin
Q33915005Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer
Q36644577Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins
Q28386047Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis
Q38107451Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
Q36700657Matrix metalloproteinases in inflammatory bowel disease: boon or a bane?
Q35873741Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1.
Q26852678Mechanisms regulating the degradation of dentin matrices by endogenous dentin proteases and their role in dental adhesion. A review
Q33824933Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep sea Pseudoalteromonas sp. SM9913: binding of the PKD domain to collagen results in collagen swelling but does not unwi
Q37030862Metalloproteases as potential therapeutic targets in arthritis treatment
Q40958958Modified platelet deposition on matrix metalloproteinase 13 digested collagen I.
Q37863911Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting
Q42574430Molecular mechanism of force induced stabilization of collagen against enzymatic breakdown
Q33991179Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases.
Q36101292Molecular structure of the collagen triple helix
Q36344116Multiplexed single-molecule force proteolysis measurements using magnetic tweezers
Q33828060Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf.
Q58618940NMR Spectroscopy and Metal Ions in Life Sciences
Q30819698NMR dispersion investigations of enzymatically degraded bovine articular cartilage
Q36797511Naringenin targets ERK2 and suppresses UVB-induced photoaging
Q47803649Neoepitopes reveal the features of type II collagen cleavage and the identity of a collagenase involved in the transformation of the epiphyses anlagen in development
Q26866319Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins
Q42119493Orientation within the exosporium and structural stability of the collagen-like glycoprotein BclA of Bacillus anthracis
Q30739775Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12.
Q37865017Peyronie's disease: perspectives on therapeutic targets
Q41854776Phagocytosis and remodeling of collagen matrices
Q45144490Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond
Q45308833Prediction of collagen stability from amino acid sequence
Q36318930Preferential sites for intramolecular glucosepane cross-link formation in type I collagen: A thermodynamic study.
Q43090809Probing collagen/enzyme mechanochemistry in native tissue with dynamic, enzyme-induced creep
Q36781961Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation
Q39469580Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only
Q33608536Progress in matrix metalloproteinase research
Q37431546Proteolytic cleavage of type I collagen generates an autoantigen in autoimmune uveitis
Q33356719Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen
Q37078072Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?
Q24324889Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta
Q37576144Relevant In Vitro Predictors of Human Acellular Dermal Matrix-Associated Inflammation and Capsule Formation in a Nonhuman Primate Subcutaneous Tissue Expander Model
Q47112384Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril.
Q40089357Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition
Q50055586Single-Molecule Assay for Proteolytic Susceptibility: Force-Induced Collagen Destabilization
Q36055116Single-molecule tracking of collagenase on native type I collagen fibrils reveals degradation mechanism
Q38962825Stabilization of dentin matrix after cross-linking treatments, in vitro.
Q43620073Structural and mechanistic insights into collagen degradation by a bacterial collagenolytic serine protease in the subtilisin family
Q27676701Structural basis for matrix metalloproteinase 1-catalyzed collagenolysis
Q34708862Structural basis of collagen fiber degradation by cathepsin K.
Q46855555Structural heterogeneity of type I collagen triple helix and its role in osteogenesis imperfecta.
Q27670630Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1
Q91891764Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling
Q27674472Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis
Q38430238Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.
Q35997938Study of HMG-CoA Reductase Inhibition Activity of the Hydrolyzed Product of Snakehead Fish (Channa striata) Skin Collagen with 50 kDa Collagenase from Bacillus licheniformis F11.4.
Q89498718Substitutions for arginine at position 780 in triple helical domain of the α1(I) chain alter folding of the type I procollagen molecule and cause osteogenesis imperfecta
Q54452193Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.
Q97643256TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1
Q42799416Tailoring the properties of cholecyst-derived extracellular matrix using carbodiimide cross-linking
Q58555880The C-terminal segment of collagenase in binds collagen to enhance collagenolysis
Q44506060The collagenolytic action of MMP-1 is regulated by the interaction between the catalytic domain and the hinge region
Q30460936The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale
Q43076523The effect of polymorphisms in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophyseal adenoma.
Q34153159The emerging role of Clostridium histolyticum collagenase in the treatment of Dupuytren disease.
Q49978939The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site.
Q33930628The extracellular matrix contributes to mechanotransduction in uterine fibroids
Q35639806The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite.
Q40129817The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains
Q35204098The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage
Q33261566The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity
Q37539660The term basal plate of the human placenta as a source of functional extravillous trophoblast cells
Q84739498The zymographic evaluation of gelatinase (MMP-2 and -9) levels in acute and chronic periapical abscesses
Q36865326Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors
Q37109082Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells
Q84408516pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain

Search more.