Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

scientific article

Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1608520113
P932PMC publication ID5150382
P698PubMed publication ID27872312

P50authorWolfgang BäumerQ53115960
Glenn CruseQ55079496
Dean D. MetcalfeQ90856971
P2093author name stringMichael A Beaven
Tomoki Fukuyama
Yuzhi Yin
Avanti Desai
Greer K Arthur
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IgE alone promotes human lung mast cell survival through the autocrine production of IL-6.Q33316194
The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathologyQ33652544
Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE.Q33870977
Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouseQ33950856
Structural organization of the human MS4A gene cluster on Chromosome 11q12.Q34085880
Measuring Mast Cell Mediator ReleaseQ34313871
Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.Q34334536
The role of the FcepsilonRI beta-chain in allergic diseasesQ34341827
A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survivalQ34378845
IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashionQ34624804
TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator releaseQ36087376
Mast cells in airway diseases and interstitial lung diseaseQ36260500
Cell cycle-associated changes in receptors for IgE during growth and differentiation of a rat basophilic leukemia cell lineQ36357912
Integrated signalling pathways for mast-cell activationQ36392833
Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.Q36689929
The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (Fc epsilon RI).Q36838446
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cellsQ36959535
Suspension culture of human mast cells/basophils from umbilical cord blood mononuclear cellsQ37343174
The first transmembrane region of the beta-chain stabilizes the tetrameric Fc epsilon RI complexQ37349519
Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases?Q37895541
Therapies for allergic inflammation: refining strategies to induce toleranceQ38007833
Atopic dermatitis: a practice parameter update 2012.Q38078475
Antisense-mediated exon skipping: taking advantage of a trick from Mother Nature to treat rare genetic diseasesQ38184276
Exon-skipping antisense oligonucleotides to correct missplicing in neurogenetic diseasesQ38186137
New developments in exon skipping and splice modulation therapies for neuromuscular diseasesQ38195295
Anti-IgE therapy: clinical utility and mechanistic insights.Q38305608
The role of FcεRI expressed in dendritic cells and monocytesQ38365223
Exon skipping therapy for Duchenne muscular dystrophyQ38484810
Functions of dendritic-cell-bound IgE in allergyQ38519794
Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factorQ39782433
Generation, isolation, and maintenance of rodent mast cells and mast cell linesQ39988963
CD20: a regulator of cell-cycle progression of B lymphocytesQ40393831
The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinaseQ40634199
Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.Q40640528
A 2.8 Mb YAC contig in 11q12-q13 localizes candidate genes for atopy: Fc epsilon RI beta and CD20.Q40701771
Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functionsQ40848612
Functional KCa3.1 K+ channels are required for human lung mast cell migrationQ40985571
Functional KCa3.1 K+ channels are required for human fibrocyte migrationQ41855879
A second amplifier function for the allergy-associated Fc(epsilon)RI-beta subunitQ42801106
Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy waterQ43624624
Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis.Q44858410
Molecular dissection of the FcRbeta signaling amplifierQ45038646
Eteplirsen for the treatment of Duchenne muscular dystrophyQ45855674
The number and affinity of IgE receptors on dispersed human lung mast cellsQ71042943
Regulation of mast cell survival by IgEQ74070693
Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survivalQ74070699
Evidence for association and linkage between atopy, airway hyper-responsiveness, and the beta subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian populationQ74169560
P433issue49
P407language of work or nameEnglishQ1860
P921main subjectmast cellQ191989
P1104number of pages6
P304page(s)14115-14120
P577publication date2016-11-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleExon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy
P478volume113

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cites work (P2860)
Q54213225Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul That Continues Today.
Q38642037The transcriptional program, functional heterogeneity, and clinical targeting of mast cells.

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