Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer

scientific article published on 20 January 2014

Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...985296L
P356DOI10.1371/JOURNAL.PONE.0085296
P932PMC publication ID3896370
P698PubMed publication ID24465527
P5875ResearchGate publication ID259919708

P2093author name stringChao Zhang
Zheng Zhou
Ning Qin
Xiaolong Chen
Danqing Xu
Xiongwen Zhang
Yanfen Fang
Meifang Zhang
Zhaohu Lin
P2860cites workComparison of cadherin-17 expression between primary colorectal adenocarcinomas and their corresponding metastases: the possibility of a diagnostic marker for detecting the primary site of metastatic tumour.Q53438167
Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer.Q53617820
Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive systemQ63641957
A clinicopathological study on the expression of cadherin-17 and caudal-related homeobox transcription factor (CDX2) in human gastric carcinomaQ80916511
Li-cadherin is inversely correlated with galectin-3 expression in gastric cancerQ81591712
Improving outcome for scirrhous gastric cancerQ83719669
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceQ24645668
LI-cadherin: a marker of gastric metaplasia and neoplasiaQ24669690
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
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Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapyQ33316645
Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancerQ33557996
Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreasQ34208599
Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis.Q34324655
Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma.Q34392558
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotypeQ34619635
Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapyQ35154288
The functional interactions between the p53 and MAPK signaling pathwaysQ35649728
Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinomaQ35893965
Knockdown of liver-intestine cadherin decreases BGC823 cell invasiveness and metastasis in vivoQ36066837
Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFκB signaling pathwayQ36677718
Integrin-mediated signalling through the MAP-kinase pathway.Q37076237
The regulation of extracellular signal-regulated kinase (ERK) in mammalian cellsQ37194140
CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia.Q38361516
Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis.Q39162923
Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transitionQ39631415
Lentiviral-mediated miRNA against liver-intestine cadherin suppresses tumor growth and invasiveness of human gastric cancerQ39700659
Blockade of proliferation and migration of gastric cancer via targeting CDH17 with an artificial microRNA.Q39714510
Identification of liver-intestine cadherin in hepatocellular carcinoma--a potential disease marker.Q40615909
Global gene expression analysis of gastric cancer by oligonucleotide microarrays.Q40667345
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e85296
P577publication date2014-01-20
P1433published inPLOS OneQ564954
P1476titleTargeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer
P478volume9